Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ML0269 | ML0758 | gene:17574088 | gene:17574582 | Putative F420-dependent glucose-6-phosphate dehydrogenase; Catalyzes the coenzyme F420-dependent oxidation of glucose 6- phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. | Putative oxidoreductase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. In the N-terminal section; belongs to the CofE family. | 0.978 |
| ML0269 | ML0759 | gene:17574088 | gene:17574583 | Putative F420-dependent glucose-6-phosphate dehydrogenase; Catalyzes the coenzyme F420-dependent oxidation of glucose 6- phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. | Conserved hypothetical protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.981 |
| ML0269 | ML1492 | gene:17574088 | gene:17575332 | Putative F420-dependent glucose-6-phosphate dehydrogenase; Catalyzes the coenzyme F420-dependent oxidation of glucose 6- phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. | Conserved hypothetical protein; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine; In the C-terminal section; belongs to the radical SAM superfamily. CofH family. | 0.955 |
| ML0269 | ML1680 | gene:17574088 | gene:17575523 | Putative F420-dependent glucose-6-phosphate dehydrogenase; Catalyzes the coenzyme F420-dependent oxidation of glucose 6- phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. | Conserved hypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. | 0.977 |
| ML0269 | rplC | gene:17574088 | gene:17575711 | Putative F420-dependent glucose-6-phosphate dehydrogenase; Catalyzes the coenzyme F420-dependent oxidation of glucose 6- phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. | 50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | 0.642 |
| ML0348 | ML0758 | gene:17574167 | gene:17574582 | Similar to M. tuberculosis Rv3520c, possible coenzyme F420-dependent enzyme, TR:O53565 (EMBL:AL123456) (347 aa); Fasta score E(): 0, 86.8% identity in 342 aa overlap. Shows weak similarity to Methanobacterium thermoautotrophicum mer, methylenetetrahydromethanopterin reductase, TR:Q50744 (EMBL:X86477) (321 aa); Fasta score E(): 2.8e-05, 27.1% identity in 332 aa overlap. | Putative oxidoreductase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. In the N-terminal section; belongs to the CofE family. | 0.788 |
| ML0348 | ML0759 | gene:17574167 | gene:17574583 | Similar to M. tuberculosis Rv3520c, possible coenzyme F420-dependent enzyme, TR:O53565 (EMBL:AL123456) (347 aa); Fasta score E(): 0, 86.8% identity in 342 aa overlap. Shows weak similarity to Methanobacterium thermoautotrophicum mer, methylenetetrahydromethanopterin reductase, TR:Q50744 (EMBL:X86477) (321 aa); Fasta score E(): 2.8e-05, 27.1% identity in 332 aa overlap. | Conserved hypothetical protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.756 |
| ML0348 | ML1492 | gene:17574167 | gene:17575332 | Similar to M. tuberculosis Rv3520c, possible coenzyme F420-dependent enzyme, TR:O53565 (EMBL:AL123456) (347 aa); Fasta score E(): 0, 86.8% identity in 342 aa overlap. Shows weak similarity to Methanobacterium thermoautotrophicum mer, methylenetetrahydromethanopterin reductase, TR:Q50744 (EMBL:X86477) (321 aa); Fasta score E(): 2.8e-05, 27.1% identity in 332 aa overlap. | Conserved hypothetical protein; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine; In the C-terminal section; belongs to the radical SAM superfamily. CofH family. | 0.652 |
| ML0348 | ML1680 | gene:17574167 | gene:17575523 | Similar to M. tuberculosis Rv3520c, possible coenzyme F420-dependent enzyme, TR:O53565 (EMBL:AL123456) (347 aa); Fasta score E(): 0, 86.8% identity in 342 aa overlap. Shows weak similarity to Methanobacterium thermoautotrophicum mer, methylenetetrahydromethanopterin reductase, TR:Q50744 (EMBL:X86477) (321 aa); Fasta score E(): 2.8e-05, 27.1% identity in 332 aa overlap. | Conserved hypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. | 0.600 |
| ML0565 | ML0759 | gene:17574386 | gene:17574583 | Putative transcriptional regulator; Involved in cell division and chromosome segregation. | Conserved hypothetical protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.833 |
| ML0565 | ML1175 | gene:17574386 | gene:17575005 | Putative transcriptional regulator; Involved in cell division and chromosome segregation. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.762 |
| ML0756 | ML0758 | gene:17574580 | gene:17574582 | Probable DNA methylase; Similar to Mycobacterium tuberculosis putative DNA methylase RV3263 OR MTCY71.03 TR:P96868 (EMBL:Z92771) fasta scores: E(): 0, 81.9% id in 541 aa and to Escherichia coli modification methylase eco57IM SW:MT57_ECOLI (P25240) fasta scores: E(): 0, 31.4% id in 525 aa. Contains PS00092 N-6 Adenine-specific DNA methylases signature. | Putative oxidoreductase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. In the N-terminal section; belongs to the CofE family. | 0.772 |
| ML0756 | ML0759 | gene:17574580 | gene:17574583 | Probable DNA methylase; Similar to Mycobacterium tuberculosis putative DNA methylase RV3263 OR MTCY71.03 TR:P96868 (EMBL:Z92771) fasta scores: E(): 0, 81.9% id in 541 aa and to Escherichia coli modification methylase eco57IM SW:MT57_ECOLI (P25240) fasta scores: E(): 0, 31.4% id in 525 aa. Contains PS00092 N-6 Adenine-specific DNA methylases signature. | Conserved hypothetical protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.772 |
| ML0758 | ML0269 | gene:17574582 | gene:17574088 | Putative oxidoreductase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. In the N-terminal section; belongs to the CofE family. | Putative F420-dependent glucose-6-phosphate dehydrogenase; Catalyzes the coenzyme F420-dependent oxidation of glucose 6- phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. | 0.978 |
| ML0758 | ML0348 | gene:17574582 | gene:17574167 | Putative oxidoreductase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. In the N-terminal section; belongs to the CofE family. | Similar to M. tuberculosis Rv3520c, possible coenzyme F420-dependent enzyme, TR:O53565 (EMBL:AL123456) (347 aa); Fasta score E(): 0, 86.8% identity in 342 aa overlap. Shows weak similarity to Methanobacterium thermoautotrophicum mer, methylenetetrahydromethanopterin reductase, TR:Q50744 (EMBL:X86477) (321 aa); Fasta score E(): 2.8e-05, 27.1% identity in 332 aa overlap. | 0.788 |
| ML0758 | ML0756 | gene:17574582 | gene:17574580 | Putative oxidoreductase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. In the N-terminal section; belongs to the CofE family. | Probable DNA methylase; Similar to Mycobacterium tuberculosis putative DNA methylase RV3263 OR MTCY71.03 TR:P96868 (EMBL:Z92771) fasta scores: E(): 0, 81.9% id in 541 aa and to Escherichia coli modification methylase eco57IM SW:MT57_ECOLI (P25240) fasta scores: E(): 0, 31.4% id in 525 aa. Contains PS00092 N-6 Adenine-specific DNA methylases signature. | 0.772 |
| ML0758 | ML0759 | gene:17574582 | gene:17574583 | Putative oxidoreductase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. In the N-terminal section; belongs to the CofE family. | Conserved hypothetical protein; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.999 |
| ML0758 | ML1492 | gene:17574582 | gene:17575332 | Putative oxidoreductase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. In the N-terminal section; belongs to the CofE family. | Conserved hypothetical protein; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine; In the C-terminal section; belongs to the radical SAM superfamily. CofH family. | 0.943 |
| ML0758 | ML1680 | gene:17574582 | gene:17575523 | Putative oxidoreductase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. In the N-terminal section; belongs to the CofE family. | Conserved hypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. | 0.984 |
| ML0758 | pepQ | gene:17574582 | gene:17574342 | Putative oxidoreductase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. In the N-terminal section; belongs to the CofE family. | Putative cytoplasmic peptidase; Similar to M. tuberculosis pepQ, Rv2535c, putative cytoplasmic peptidase, TR:P95018 (EMBL:AL123456) (372 aa); Fasta score E(): 0, 83.0% identity in 376 aa overlap. Similar to many e.g. Pyrococcus furiosus cobalt-dependent proline dipeptidase, TR:P81535 (EMBL:AF060010) (348 aa); Fasta score E(): 1.6e-29, 33.7% identity in 359 aa overlap. Contains Pfam match to entry PF00557 Peptidase_M24, metallopeptidase family M24. Contains PS00491 Aminopeptidase P and proline dipeptidase signature. Contains PS00211 ABC transporters family signature. | 0.777 |
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