STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gpsIPutative polyribonucleotide phosphorylase / guanosine pentaphosphate synthetase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (773 aa)    
Predicted Functional Partners:
rhlE
Similar to Mycobacterium tuberculosis putative ATP-dependent RNA helicase Rv3211 or MTCY07D11.15c (407 aa) TR:O05855 (EMBL:Z95120) fasta scores: E(): 0, 74.8% id in 531 aa, and to Klebsiella pneumoniae ATP-dependent RNA helicase deaD SW:DEAD_KLEPN (P33906) fasta scores: E(): 0, 43.2% id in 380 aa. Contains Pfam match to entry PF00271 helicase_C, Helicases conserved C-terminal domain. Contains Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00039 DEAD-box subfamily ATP-dependent helicases signature.
 
 
 0.957
ML1468
Possible ribonuclease; Highly similar in parts to many ribonucleases e.g. Escherichia coli ribonuclease E (EC 3.1.4.-) SW:RNE_ECOLI (P21513) (1061 aa); Fasta score E(): 1.6e-22, 36.4% identity in 429 aa overlap and Mycobacterium tuberculosis RV2444C TR:P71905 (EMBL:Z81451) (953 aa); Fasta score E(): 0, 74.2% identity in 966 aa overlap. Contains Pfam match to entry PF00575 S1, S1 RNA binding domain.
  
 
 0.942
rpsO
30S ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
 
  
 0.863
rho
Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.
   
  
 0.857
pepR
Putative zinc protease; EC_number=3.4.99.-; Similar to Mycobacterium tuberculosis hypothetical zinc protease Rv2782c or MTV002.47C SW:YR82_MYCTU (O33324) (438 aa) fasta scores: E(): 0, 84.3% id in 421 aa and to others, both bacterial and eukaryotic e.g. Homo sapiens mitochondrial processing peptidase beta subunit precursor pmpcB or mppB SW:MPPB_HUMAN (O75439) (489 aa) fasta scores: E(): 0, 30.6% id in 434 aa. Previously sequenced as SW:YR82_MYCLE (O32965). Contains Pfam match to entry PF00675 Peptidase_M16, Insulinase (Peptidase family M16). Contains PS00143 Insulinase family, zinc-bin [...]
  
 
 0.839
ML1512
Conserved hypothetical protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
 
  
 0.835
infB
Initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
  
  
 0.825
rphA
Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
   
  
 0.797
fusA
Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...]
   
 
 0.785
nusA
Probable transcription termination/antitermination factor; Participates in both transcription termination and antitermination.
 
  
 0.784
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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