STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cobTPutative nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (351 aa)    
Predicted Functional Partners:
ML1637
Conserved hypothetical protein; Similar in parts to many. The N-terminus is similar to several ribonucleases e.g. Escherichia coli ribonuclease HI (EC 3.1.26.4) SW:RNH_ECOLI (P00647) (430 aa); BlastP Expect 8.7. The C-terminus is similar to many proteins belonging to the phosphoglycerate mutase family e.g. Escherichia coli SW:COBC_ECOLI (P52086) (430 aa); BlastP Expect 8.7. Similar over the whole range to Mycobacterium tuberculosis hypothetical protein RV2228C SW:YM28_MYCTU (Q10512) (364 aa); Fasta score E(): 0, 76.8% identity in 371 aa overlap. Contains Pfam match to entry PF00300 PGA [...]
 
 
 0.941
ML2084
Probable multidrug resistance pump; Similar to Mycobacterium tuberculosis hypothetical ABC transporter ATP-binding protein Rv1819c SW:YI19_MYCTU (Q50614) fasta scores: E(): 0, 74.9% in 634 aa, and in C-term to Escherichia coli hypothetical ABC transporter ATP-binding protein in pqql-hipa intergenic region SW:YDDA_ECOLI (P31826; P76133; P76876) fasta scores: E(): 0, 29.9% in 551 aa. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00211 ABC transporters family signature; Similar to ML1089, ML1424, ML0848 a [...]
      
 0.751
ML0869
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 14.0 kDa protein Rv2206 or MTCY190.17 SW:YM06_MYCTU (Q10395) (124 aa) fasta scores: E(): 0, 76.6% id in 124 aa and to part of Streptomyces coelicolor putative integral membrane protein SC5F7.32 TR:Q9S2R7 (EMBL:AL096872) (251 aa) fasta scores: E(): 3.5e-14, 34.7% id in 219 aa. Previously sequenced as TR:O32952 (EMBL:Z98741).
       0.744
ML1149
Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein SW:YD14_MYCLE (P53523) (191 aa); Fasta score E(): 0, 100.0% identity in 191 aa overlap. Also similar to many other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1314c SW:YD14_MYCTU (Q10622) (193 aa); Fasta score E(): 0, 81.2% identity in 191 aa overlap. Contains Pfam match to entry PF01923 DUF80, Protein of unknown function; Belongs to the Cob(I)alamin adenosyltransferase family.
     
 0.721
ML1005
Conserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family.
     
 0.684
hemD
Possible uroporphyrin-III C-methyltransferase; Similar to Mycobacterium tuberculosis Rv0511 TR:P95077 (EMBL:Z83865) (565 aa) fasta scores: E(): 0, 85.7% id in 565 aa and to Clostridium josui porphyrin biosynthesis protein HemD [includes: uroporphyrin-III C-methyltransferase hemD SW:HEM4_CLOJO (Q59294) (504 aa) fasta scores: E(): 3e-24, 24.4% id in 545 aa. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases.
 
  
 0.636
hisC
Highly similar to many histidinol-phosphate aminotransferases (EC 2.6.1.9) involved in histidine biosynthesis e.g. Mycobacterium tuberculosis RV1600 TR:SW:HIS8_MYCTU (O06591) (380 aa); Fasta score E(): 0, 83.6% identity in 366 aa overlap and Mycobacterium smegmatis SW:HIS8_MYCSM (P28735) (219 aa); Fasta score E(): 0, 77.2% identity in 219 aa overlap. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II.
  
  
 0.502
ML0871
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 12.5 kDa protein Rv2204c or MTCY190.15C SW:YM04_MYCTU (Q10393) (118 aa) fasta scores: E(): 0, 92.4% id in 118 aa. Similar to many hypothetical proteins e.g. Streptomyces coelicolor hypothetical 12.4 kDa protein SC6G10.34C TR:Q9X819 (EMBL:AL049497) (118 aa) fasta scores: E(): 0, 73.7% id in 118 aa. Contains Pfam match to entry PF01521 HesB-like, HesB-like domain. Contains PS01152 Hypothetical hesB/yadR/yfhF family signature; Belongs to the HesB/IscA family.
       0.493
metH
5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).
      
 0.485
ML1452
Possible phosphoglycerate mutase; Similar to several including: Salmonella typhimurium SW:COBC_SALTY (P39701) (234 aa); Fasta score E(): 5.4e-09, 29.4% identity in 197 aa overlap alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.-) involved in cobalamin biosynthesis. Also highly simlar to several proteins of undefined function e.g. Mycobacterium tuberculosis Rv2419c TR:P71724 (EMBL:Z81368) (223 aa); Fasta score E(): 0, 80.4% identity in 224 aa overlap. Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family. Contains PS00175 Phosphoglycerate mutase family phosphohisti [...]
 
  
 0.456
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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