STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
qcrBPutative cytochrome B; Cytochrome b subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of ubiquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis. The cytochrome b subunit contains two ubiquinol reactive sites: the oxidation (QP) site and the reduction (QN) site. (551 aa)    
Predicted Functional Partners:
ctaC
Putative cytochrome C oxidase chain II; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).
 
 
 0.999
ML0876
Putative membrane protein; Part of cytochrome c oxidase, its function is unknown. Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
 
 
 0.999
qcrA
Putative Rieske iron-sulphur reductase component; Similar to Mycobacterium tuberculosis putative ubiquinol-cytochrome C reductase iron-sulfur subunit qcrA or Rv2195 or MTCY190.06 SW:QCRA_MYCTU (Q10387) (429 aa) fasta scores: E(): 0, 80.9% id in 398 aa. Contains hydrophobic, probable membrane-spanning regions. Contains PS00200 Rieske iron-sulfur protein signature 2.
 
 0.999
qcrC
Putative cytochrome C reductase cytochrome C component; Cytochrome b subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of ubiquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.
 
 0.999
ctaE
Cytochrome C oxidase subunit III; Similar to Mycobacterium tuberculosis probable cytochrome C oxidase polypeptide III ctaE or Rv2193 or MTCY190.04 SW:COX3_MYCTU (Q10385) (203 aa) fasta scores: E(): 0, 90.1% id in 203 aa. Similar to many e.g. Synechococcus vulcanus cytochrome C oxidase polypeptide III ctaE SW:COX3_SYNVU (P50677) (201 aa) fasta scores: E(): 1.2e-23, 39.0% id in 200 aa. Previously sequenced as TR:O69582 (EMBL:AL022602). Contains hydrophobic, probable membrane-spanning regions. Contains Pfam match to entry PF00510 COX3, Cytochrome c oxidase subunit III.
 
 
 0.999
ML1584
Possible conserved membrane protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV2876 SW:YS76_MYCTU (Q10802) (104 aa); Fasta score E(): 3.3e-26, 75.0% identity in 88 aa overlap. Contains possible membrane spanning hydrophobic domains.
    
   0.999
ML1728
Cytochrome C oxidase, polypeptide I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).
 
 
 0.999
sodC
Superoxide dismutase precursor (Cu-Zn); Destroys radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in favoring mycobacterial survival in phagocytes (By similarity).
    
 
 0.999
ML2155
Conserved hypothetical protein; Similar to C-terminus of Mycobacterium tuberculosis hypothetical 10.1 kda protein TR:O53875 (EMBL:AL022004) fasta scores: E(): 1.5e-21, 74.0% in 73 aa.
    
   0.999
ML2355
Similar to several polyketide synthases e.g. Mycobacterium tuberculosis Rv2933 TR:P96202 (EMBL:Z83857) (2188 aa) fasta scores: E(): 0, 82.3% id in 2217 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00133 Zinc carboxypeptidases. Contains PS00606 Beta-ketoacyl [...]
   
 
 0.999
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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