STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
qcrCPutative cytochrome C reductase cytochrome C component; Cytochrome b subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of ubiquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis. (289 aa)    
Predicted Functional Partners:
ctaC
Putative cytochrome C oxidase chain II; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).
 
 
 0.999
ML0876
Putative membrane protein; Part of cytochrome c oxidase, its function is unknown. Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
 
 
 
 0.999
qcrB
Putative cytochrome B; Cytochrome b subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of ubiquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis. The cytochrome b subunit contains two ubiquinol reactive sites: the oxidation (QP) site and the reduction (QN) site.
 
 0.999
qcrA
Putative Rieske iron-sulphur reductase component; Similar to Mycobacterium tuberculosis putative ubiquinol-cytochrome C reductase iron-sulfur subunit qcrA or Rv2195 or MTCY190.06 SW:QCRA_MYCTU (Q10387) (429 aa) fasta scores: E(): 0, 80.9% id in 398 aa. Contains hydrophobic, probable membrane-spanning regions. Contains PS00200 Rieske iron-sulfur protein signature 2.
 
 0.999
ctaE
Cytochrome C oxidase subunit III; Similar to Mycobacterium tuberculosis probable cytochrome C oxidase polypeptide III ctaE or Rv2193 or MTCY190.04 SW:COX3_MYCTU (Q10385) (203 aa) fasta scores: E(): 0, 90.1% id in 203 aa. Similar to many e.g. Synechococcus vulcanus cytochrome C oxidase polypeptide III ctaE SW:COX3_SYNVU (P50677) (201 aa) fasta scores: E(): 1.2e-23, 39.0% id in 200 aa. Previously sequenced as TR:O69582 (EMBL:AL022602). Contains hydrophobic, probable membrane-spanning regions. Contains Pfam match to entry PF00510 COX3, Cytochrome c oxidase subunit III.
 
 
 0.999
ML1584
Possible conserved membrane protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV2876 SW:YS76_MYCTU (Q10802) (104 aa); Fasta score E(): 3.3e-26, 75.0% identity in 88 aa overlap. Contains possible membrane spanning hydrophobic domains.
    
   0.999
ML1728
Cytochrome C oxidase, polypeptide I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).
 
 
 0.999
tuf
Elongation factor EF-Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.
  
 
 0.962
lpqE
Putative lipoprotein; Similar to M. tuberculosis lpqE, Rv3584, putative lipoprotein, TR:O53569 (EMBL:AL123456) (182 aa); Fasta score E(): 0, 63.4% identity in 175 aa overlap. Previously sequenced as TR:Q9ZBM7 (EMBL:AL035159) (183 aa); Fasta score E(): 0, 99.5% identity in 183 aa overlap. Contains a probable N-terminal signal sequnce. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
   
 
 0.960
choD
Putative cholesterol oxidase; Similar to M. tuberculosis choD, Rv3409c, putative cholesterol oxidase, TR:Q57307 (EMBL:Al123456) (578 aa); Fasta score E(): 0, 88.6% identity in 569 aa overlap. Similar to Streptomyces sp. (strain SA-COO) choA, cholesterol oxidase precursor, SW:CHOD_STRSQ (P12676) (546 aa); Fasta score E(): 0.013, 26.6% identity in 561 aa overlap. Previously sequenced as TR:Q59530 (EMBL:U00015) (585 aa); Fasta score E(): 0, 100.0% identity in 569 aa overlap.
  
 
 0.908
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.