STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ML0989Conserved hypothetical protein; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (517 aa)    
Predicted Functional Partners:
miaA
tRNA [delta](2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family.
 
  
 0.935
ML0990
Possible conserved membrane protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49834 (EMBL:U00019) (209 aa); Fasta score E(): 0, 100.0% identity in 209 aa overlap. Also highly similar to Mycobacterium tuberculosis Rv2732c TR:O33237 (EMBL:Z98209) (204 aa); Fasta score E(): 0, 70.6% identity in 201 aa overlap. Contains possible membrane spanning hydrophobic domains.
       0.859
recX
Putative regulatory protein RecX; Modulates RecA activity; Belongs to the RecX family.
     
 0.757
ML1061
Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49952 (EMBL:U15180) (187 aa); Fasta score E(): 0, 100.0% identity in 187 aa overlap. Also highly similar to Mycobacterium tuberculosis TR:O05306 (EMBL:Z93777) (187 aa); Fasta score E(): 0, 72.4% identity in 174 aa overlap; Belongs to the LOG family.
      
 0.731
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity).
  
  
 0.679
rphA
Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
  
   0.568
mrp
MRP-family ATP-binding protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; In the N-terminal section; belongs to the MIP18 family.
  
  
 0.515
gpsI
Putative polyribonucleotide phosphorylase / guanosine pentaphosphate synthetase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
 
  
 0.465
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
  
  
 0.465
dapF
Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan.
     
 0.460
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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