node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML0997 | dapF | gene:17574823 | gene:17574822 | Possible ATP/GTP-binding protein; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.873 |
ML1058 | ML1488 | gene:17574884 | gene:17575328 | Possible tranferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. | Possible aminotransferase; Weakly similar to several putative aminotransferases including: Neisseria meningitidis TR:AAF41303 (EMBL:AE002441) (395 aa); Fasta score E(): 5.1e-13, 29.8% identity in 373 aa overlap and Mycobacterium tuberculosis RV1178 TR:O50434 (EMBL:AL010186) (362 aa); Fasta score E(): 0, 83.4% identity in 361 aa overlap. Contains PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. | 0.881 |
ML1058 | asd | gene:17574884 | gene:17576183 | Possible tranferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.785 |
ML1058 | ask | gene:17574884 | gene:17576184 | Possible tranferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. | Aspartokinase; Similar to Mycobacterium tuberculosis aspartokinase ask or rv3709c or mtv025.057C SW:AK_MYCTU (P97048; O69676; P97181) (421 aa) fasta scores: E(): 0, 92.6% id in 421 aa, and to Mycobacterium smegmatis aspartokinase asK SW:AK_MYCSM (P41403) (421 aa) fasta scores: E(): 0, 85.3% id in 421 aa. Contains Pfam match to entry PF00696 aakinase, Amino acid kinase family. Contains Pfam match to entry PF01842 ACT, ACT domain. Contains PS00324 Aspartokinase signature. | 0.790 |
ML1058 | dapA | gene:17574884 | gene:17575354 | Possible tranferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.859 |
ML1058 | dapE | gene:17574884 | gene:17574885 | Possible tranferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. | Succinyl-diaminopimelate desuccinylase; Identical to the previously sequenced Mycobacterium leprae TR:Q49949 (EMBL:U15180) (400 aa); Fasta score E(): 0, 100.0% identity in 354 aa overlap. Also highly similar to succinyl-diaminopimelate desuccinylases from Mycobacterium tuberculosis Rv1202 TR:O05303 (EMBL:Z93777) (354 aa); Fasta score E(): 0, 86.7% identity in 354 aa overlap and Corynebacterium glutamicum SW:DAPE_CORG (Q59284) (369 aa); Fasta score E(): 0, 56.3% identity in 359 aa overlapL. Contains Pfam match to entry PF01546 Peptidase_M20, Peptidase family M20/M25/M40. Contains PS0075 [...] | 0.980 |
ML1058 | dapF | gene:17574884 | gene:17574822 | Possible tranferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.856 |
ML1058 | lysA | gene:17574884 | gene:17574955 | Possible tranferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.781 |
ML1058 | murE | gene:17574884 | gene:17574735 | Possible tranferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.747 |
ML1488 | ML1058 | gene:17575328 | gene:17574884 | Possible aminotransferase; Weakly similar to several putative aminotransferases including: Neisseria meningitidis TR:AAF41303 (EMBL:AE002441) (395 aa); Fasta score E(): 5.1e-13, 29.8% identity in 373 aa overlap and Mycobacterium tuberculosis RV1178 TR:O50434 (EMBL:AL010186) (362 aa); Fasta score E(): 0, 83.4% identity in 361 aa overlap. Contains PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. | Possible tranferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. | 0.881 |
ML1488 | asd | gene:17575328 | gene:17576183 | Possible aminotransferase; Weakly similar to several putative aminotransferases including: Neisseria meningitidis TR:AAF41303 (EMBL:AE002441) (395 aa); Fasta score E(): 5.1e-13, 29.8% identity in 373 aa overlap and Mycobacterium tuberculosis RV1178 TR:O50434 (EMBL:AL010186) (362 aa); Fasta score E(): 0, 83.4% identity in 361 aa overlap. Contains PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.465 |
ML1488 | ask | gene:17575328 | gene:17576184 | Possible aminotransferase; Weakly similar to several putative aminotransferases including: Neisseria meningitidis TR:AAF41303 (EMBL:AE002441) (395 aa); Fasta score E(): 5.1e-13, 29.8% identity in 373 aa overlap and Mycobacterium tuberculosis RV1178 TR:O50434 (EMBL:AL010186) (362 aa); Fasta score E(): 0, 83.4% identity in 361 aa overlap. Contains PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. | Aspartokinase; Similar to Mycobacterium tuberculosis aspartokinase ask or rv3709c or mtv025.057C SW:AK_MYCTU (P97048; O69676; P97181) (421 aa) fasta scores: E(): 0, 92.6% id in 421 aa, and to Mycobacterium smegmatis aspartokinase asK SW:AK_MYCSM (P41403) (421 aa) fasta scores: E(): 0, 85.3% id in 421 aa. Contains Pfam match to entry PF00696 aakinase, Amino acid kinase family. Contains Pfam match to entry PF01842 ACT, ACT domain. Contains PS00324 Aspartokinase signature. | 0.527 |
ML1488 | dapA | gene:17575328 | gene:17575354 | Possible aminotransferase; Weakly similar to several putative aminotransferases including: Neisseria meningitidis TR:AAF41303 (EMBL:AE002441) (395 aa); Fasta score E(): 5.1e-13, 29.8% identity in 373 aa overlap and Mycobacterium tuberculosis RV1178 TR:O50434 (EMBL:AL010186) (362 aa); Fasta score E(): 0, 83.4% identity in 361 aa overlap. Contains PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.719 |
ML1488 | dapE | gene:17575328 | gene:17574885 | Possible aminotransferase; Weakly similar to several putative aminotransferases including: Neisseria meningitidis TR:AAF41303 (EMBL:AE002441) (395 aa); Fasta score E(): 5.1e-13, 29.8% identity in 373 aa overlap and Mycobacterium tuberculosis RV1178 TR:O50434 (EMBL:AL010186) (362 aa); Fasta score E(): 0, 83.4% identity in 361 aa overlap. Contains PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. | Succinyl-diaminopimelate desuccinylase; Identical to the previously sequenced Mycobacterium leprae TR:Q49949 (EMBL:U15180) (400 aa); Fasta score E(): 0, 100.0% identity in 354 aa overlap. Also highly similar to succinyl-diaminopimelate desuccinylases from Mycobacterium tuberculosis Rv1202 TR:O05303 (EMBL:Z93777) (354 aa); Fasta score E(): 0, 86.7% identity in 354 aa overlap and Corynebacterium glutamicum SW:DAPE_CORG (Q59284) (369 aa); Fasta score E(): 0, 56.3% identity in 359 aa overlapL. Contains Pfam match to entry PF01546 Peptidase_M20, Peptidase family M20/M25/M40. Contains PS0075 [...] | 0.951 |
ML1488 | dapF | gene:17575328 | gene:17574822 | Possible aminotransferase; Weakly similar to several putative aminotransferases including: Neisseria meningitidis TR:AAF41303 (EMBL:AE002441) (395 aa); Fasta score E(): 5.1e-13, 29.8% identity in 373 aa overlap and Mycobacterium tuberculosis RV1178 TR:O50434 (EMBL:AL010186) (362 aa); Fasta score E(): 0, 83.4% identity in 361 aa overlap. Contains PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.891 |
ML1488 | lysA | gene:17575328 | gene:17574955 | Possible aminotransferase; Weakly similar to several putative aminotransferases including: Neisseria meningitidis TR:AAF41303 (EMBL:AE002441) (395 aa); Fasta score E(): 5.1e-13, 29.8% identity in 373 aa overlap and Mycobacterium tuberculosis RV1178 TR:O50434 (EMBL:AL010186) (362 aa); Fasta score E(): 0, 83.4% identity in 361 aa overlap. Contains PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.766 |
asd | ML1058 | gene:17576183 | gene:17574884 | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Possible tranferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. | 0.785 |
asd | ML1488 | gene:17576183 | gene:17575328 | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Possible aminotransferase; Weakly similar to several putative aminotransferases including: Neisseria meningitidis TR:AAF41303 (EMBL:AE002441) (395 aa); Fasta score E(): 5.1e-13, 29.8% identity in 373 aa overlap and Mycobacterium tuberculosis RV1178 TR:O50434 (EMBL:AL010186) (362 aa); Fasta score E(): 0, 83.4% identity in 361 aa overlap. Contains PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. | 0.465 |
asd | ask | gene:17576183 | gene:17576184 | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Aspartokinase; Similar to Mycobacterium tuberculosis aspartokinase ask or rv3709c or mtv025.057C SW:AK_MYCTU (P97048; O69676; P97181) (421 aa) fasta scores: E(): 0, 92.6% id in 421 aa, and to Mycobacterium smegmatis aspartokinase asK SW:AK_MYCSM (P41403) (421 aa) fasta scores: E(): 0, 85.3% id in 421 aa. Contains Pfam match to entry PF00696 aakinase, Amino acid kinase family. Contains Pfam match to entry PF01842 ACT, ACT domain. Contains PS00324 Aspartokinase signature. | 0.999 |
asd | dapA | gene:17576183 | gene:17575354 | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.990 |