node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML1359 | ppgK | gene:17575197 | gene:17574849 | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Polyphosphate glucokinase; Catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. | 0.455 |
deoC | fba | gene:17576314 | gene:17574105 | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. | Putative fructose bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. | 0.908 |
deoC | pgi | gene:17576314 | gene:17573965 | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. | Glucose-6-phosphate isomerase; Similar to M. tuberculosis Rv0946c, pgi, glucose-6-phosphate isomerase, SW:G6PI_MYCTU (P77895) (553 aa); Fasta score E(): 0, 85.5% identity in 552 aa overlap and Mycobacterium smegmatis pgi, glucose-6-phosphate isomerase, SW:G6PI_MYCSM (P96803) (442 aa); Fasta score E(): 0, 84.1% identity in 440 aa overlap. Contains Pfam match to entry PF00342 PGI, Phosphoglucose isomerase. Contains PS00765 Phosphoglucose isomerase signature 1. Contains PS00174 Phosphoglucose isomerase signature 2. | 0.826 |
deoC | ppgK | gene:17576314 | gene:17574849 | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. | Polyphosphate glucokinase; Catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. | 0.802 |
deoC | tal | gene:17576314 | gene:17574403 | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. | Putative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. | 0.909 |
deoC | tkt | gene:17576314 | gene:17574404 | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | 0.929 |
fba | deoC | gene:17574105 | gene:17576314 | Putative fructose bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. | 0.908 |
fba | pgi | gene:17574105 | gene:17573965 | Putative fructose bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. | Glucose-6-phosphate isomerase; Similar to M. tuberculosis Rv0946c, pgi, glucose-6-phosphate isomerase, SW:G6PI_MYCTU (P77895) (553 aa); Fasta score E(): 0, 85.5% identity in 552 aa overlap and Mycobacterium smegmatis pgi, glucose-6-phosphate isomerase, SW:G6PI_MYCSM (P96803) (442 aa); Fasta score E(): 0, 84.1% identity in 440 aa overlap. Contains Pfam match to entry PF00342 PGI, Phosphoglucose isomerase. Contains PS00765 Phosphoglucose isomerase signature 1. Contains PS00174 Phosphoglucose isomerase signature 2. | 0.960 |
fba | ppgK | gene:17574105 | gene:17574849 | Putative fructose bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. | Polyphosphate glucokinase; Catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. | 0.841 |
fba | tal | gene:17574105 | gene:17574403 | Putative fructose bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. | Putative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. | 0.976 |
fba | tkt | gene:17574105 | gene:17574404 | Putative fructose bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | 0.954 |
gltB | ppgK | gene:17573873 | gene:17574849 | Similar to M. tuberculosis Rv3859c, putative ferredoxin-dependent glutamate synthase, TR:P96218 (EMBL:Al123456) (1527 aa); Fasta score E(): 0, 90.2% identity in 1527 aa overlap and to Synechocystis sp. gltB, ferredoxin-dependent glutamate synthase 1, SW:GLTB_SYNY3 (P55037) (1550 aa); Fasta score E(): 0, 57.2% identity in 1525 aa overlap. Contains Pfam match to entry PF01493 DUF14, Domain of unknown function. Contains Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. | Polyphosphate glucokinase; Catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. | 0.528 |
gltB | suhB | gene:17573873 | gene:17574850 | Similar to M. tuberculosis Rv3859c, putative ferredoxin-dependent glutamate synthase, TR:P96218 (EMBL:Al123456) (1527 aa); Fasta score E(): 0, 90.2% identity in 1527 aa overlap and to Synechocystis sp. gltB, ferredoxin-dependent glutamate synthase 1, SW:GLTB_SYNY3 (P55037) (1550 aa); Fasta score E(): 0, 57.2% identity in 1525 aa overlap. Contains Pfam match to entry PF01493 DUF14, Domain of unknown function. Contains Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. | Putative inositol monophosphatase; Identical to the previously sequenced Mycobacterium leprae extragenic suppressor protein SuhB homologue SW:SUHB_MYCLE (P46813) (291 aa); Fasta score E(): 0, 99.7% identity in 291 aa overlap. Also highly similar to many other members of the inositol monophosphatase family including: Mycobacterium tuberculosis, Rv2701c or ShuB, SW:SUHB_MYCTU (O07203) (290 aa); Fasta score E(): 0, 77.6% identity in 294 aa overlap and Escherichia coli ShuB, SW:SUHB_ECOLI (P22783) (267 aa); Fasta score E(): 1.6e-18, 34.7% identity in 239 aa overlap, shown to suppress the e [...] | 0.504 |
gltB | tal | gene:17573873 | gene:17574403 | Similar to M. tuberculosis Rv3859c, putative ferredoxin-dependent glutamate synthase, TR:P96218 (EMBL:Al123456) (1527 aa); Fasta score E(): 0, 90.2% identity in 1527 aa overlap and to Synechocystis sp. gltB, ferredoxin-dependent glutamate synthase 1, SW:GLTB_SYNY3 (P55037) (1550 aa); Fasta score E(): 0, 57.2% identity in 1525 aa overlap. Contains Pfam match to entry PF01493 DUF14, Domain of unknown function. Contains Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. | Putative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. | 0.490 |
gltB | tkt | gene:17573873 | gene:17574404 | Similar to M. tuberculosis Rv3859c, putative ferredoxin-dependent glutamate synthase, TR:P96218 (EMBL:Al123456) (1527 aa); Fasta score E(): 0, 90.2% identity in 1527 aa overlap and to Synechocystis sp. gltB, ferredoxin-dependent glutamate synthase 1, SW:GLTB_SYNY3 (P55037) (1550 aa); Fasta score E(): 0, 57.2% identity in 1525 aa overlap. Contains Pfam match to entry PF01493 DUF14, Domain of unknown function. Contains Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | 0.675 |
pgi | deoC | gene:17573965 | gene:17576314 | Glucose-6-phosphate isomerase; Similar to M. tuberculosis Rv0946c, pgi, glucose-6-phosphate isomerase, SW:G6PI_MYCTU (P77895) (553 aa); Fasta score E(): 0, 85.5% identity in 552 aa overlap and Mycobacterium smegmatis pgi, glucose-6-phosphate isomerase, SW:G6PI_MYCSM (P96803) (442 aa); Fasta score E(): 0, 84.1% identity in 440 aa overlap. Contains Pfam match to entry PF00342 PGI, Phosphoglucose isomerase. Contains PS00765 Phosphoglucose isomerase signature 1. Contains PS00174 Phosphoglucose isomerase signature 2. | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. | 0.826 |
pgi | fba | gene:17573965 | gene:17574105 | Glucose-6-phosphate isomerase; Similar to M. tuberculosis Rv0946c, pgi, glucose-6-phosphate isomerase, SW:G6PI_MYCTU (P77895) (553 aa); Fasta score E(): 0, 85.5% identity in 552 aa overlap and Mycobacterium smegmatis pgi, glucose-6-phosphate isomerase, SW:G6PI_MYCSM (P96803) (442 aa); Fasta score E(): 0, 84.1% identity in 440 aa overlap. Contains Pfam match to entry PF00342 PGI, Phosphoglucose isomerase. Contains PS00765 Phosphoglucose isomerase signature 1. Contains PS00174 Phosphoglucose isomerase signature 2. | Putative fructose bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. | 0.960 |
pgi | ppgK | gene:17573965 | gene:17574849 | Glucose-6-phosphate isomerase; Similar to M. tuberculosis Rv0946c, pgi, glucose-6-phosphate isomerase, SW:G6PI_MYCTU (P77895) (553 aa); Fasta score E(): 0, 85.5% identity in 552 aa overlap and Mycobacterium smegmatis pgi, glucose-6-phosphate isomerase, SW:G6PI_MYCSM (P96803) (442 aa); Fasta score E(): 0, 84.1% identity in 440 aa overlap. Contains Pfam match to entry PF00342 PGI, Phosphoglucose isomerase. Contains PS00765 Phosphoglucose isomerase signature 1. Contains PS00174 Phosphoglucose isomerase signature 2. | Polyphosphate glucokinase; Catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. | 0.938 |
pgi | tal | gene:17573965 | gene:17574403 | Glucose-6-phosphate isomerase; Similar to M. tuberculosis Rv0946c, pgi, glucose-6-phosphate isomerase, SW:G6PI_MYCTU (P77895) (553 aa); Fasta score E(): 0, 85.5% identity in 552 aa overlap and Mycobacterium smegmatis pgi, glucose-6-phosphate isomerase, SW:G6PI_MYCSM (P96803) (442 aa); Fasta score E(): 0, 84.1% identity in 440 aa overlap. Contains Pfam match to entry PF00342 PGI, Phosphoglucose isomerase. Contains PS00765 Phosphoglucose isomerase signature 1. Contains PS00174 Phosphoglucose isomerase signature 2. | Putative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. | 0.977 |
pgi | tkt | gene:17573965 | gene:17574404 | Glucose-6-phosphate isomerase; Similar to M. tuberculosis Rv0946c, pgi, glucose-6-phosphate isomerase, SW:G6PI_MYCTU (P77895) (553 aa); Fasta score E(): 0, 85.5% identity in 552 aa overlap and Mycobacterium smegmatis pgi, glucose-6-phosphate isomerase, SW:G6PI_MYCSM (P96803) (442 aa); Fasta score E(): 0, 84.1% identity in 440 aa overlap. Contains Pfam match to entry PF00342 PGI, Phosphoglucose isomerase. Contains PS00765 Phosphoglucose isomerase signature 1. Contains PS00174 Phosphoglucose isomerase signature 2. | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | 0.976 |