node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML0269 | dut | gene:17574088 | gene:17574854 | Putative F420-dependent glucose-6-phosphate dehydrogenase; Catalyzes the coenzyme F420-dependent oxidation of glucose 6- phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. | Probable deoxyuridine triphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.734 |
ML1027 | ML1029 | gene:17574853 | gene:17574855 | Possible membrane protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49991 (EMBL:U15181) (157 aa); Fasta score E(): 0, 99.4% identity in 157 aa overlap. Also highly similar to proteins of unknown function from Mycobacterium tuberculosis Rv2698 TR:O07200 (EMBL:Z96072) (161 aa); Fasta score E(): 0, 78.9% identity in 161 aa overlap and Streptomyces coelicolor TR:O54132 (EMBL:AL021530) (154 aa); Fasta score E(): 1.1e-08, 33.6% identity in 149 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains a probable helix-turn-helix m [...] | Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49993 (EMBL:U15181) (273 aa); Fasta score E(): 0, 99.6% identity in 273 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2696c TR:O07198 (EMBL:Z96072) (259 aa); Fasta score E(): 0, 70.6% identity in 262 aa overlap. | 0.814 |
ML1027 | dut | gene:17574853 | gene:17574854 | Possible membrane protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49991 (EMBL:U15181) (157 aa); Fasta score E(): 0, 99.4% identity in 157 aa overlap. Also highly similar to proteins of unknown function from Mycobacterium tuberculosis Rv2698 TR:O07200 (EMBL:Z96072) (161 aa); Fasta score E(): 0, 78.9% identity in 161 aa overlap and Streptomyces coelicolor TR:O54132 (EMBL:AL021530) (154 aa); Fasta score E(): 1.1e-08, 33.6% identity in 149 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains a probable helix-turn-helix m [...] | Probable deoxyuridine triphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.757 |
ML1029 | ML1027 | gene:17574855 | gene:17574853 | Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49993 (EMBL:U15181) (273 aa); Fasta score E(): 0, 99.6% identity in 273 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2696c TR:O07198 (EMBL:Z96072) (259 aa); Fasta score E(): 0, 70.6% identity in 262 aa overlap. | Possible membrane protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49991 (EMBL:U15181) (157 aa); Fasta score E(): 0, 99.4% identity in 157 aa overlap. Also highly similar to proteins of unknown function from Mycobacterium tuberculosis Rv2698 TR:O07200 (EMBL:Z96072) (161 aa); Fasta score E(): 0, 78.9% identity in 161 aa overlap and Streptomyces coelicolor TR:O54132 (EMBL:AL021530) (154 aa); Fasta score E(): 1.1e-08, 33.6% identity in 149 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains a probable helix-turn-helix m [...] | 0.814 |
ML1029 | dut | gene:17574855 | gene:17574854 | Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49993 (EMBL:U15181) (273 aa); Fasta score E(): 0, 99.6% identity in 273 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2696c TR:O07198 (EMBL:Z96072) (259 aa); Fasta score E(): 0, 70.6% identity in 262 aa overlap. | Probable deoxyuridine triphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.859 |
ML1514 | dut | gene:17575355 | gene:17574854 | Putative mycobacteriophage protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Probable deoxyuridine triphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.988 |
ML1514 | thyA | gene:17575355 | gene:17575360 | Putative mycobacteriophage protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.993 |
ML1514 | tmk | gene:17575355 | gene:17574596 | Putative mycobacteriophage protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | Putative thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.927 |
ML2507 | dut | gene:17576371 | gene:17574854 | Probable deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Probable deoxyuridine triphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.922 |
ML2507 | ndk | gene:17576371 | gene:17575307 | Probable deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.915 |
dnaN | dut | gene:17573811 | gene:17574854 | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | Probable deoxyuridine triphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.730 |
dnaN | nrdE | gene:17573811 | gene:17575579 | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | Ribonucleoside diphosphate reductase [alpha] chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.723 |
dnaN | thyA | gene:17573811 | gene:17575360 | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.691 |
dut | ML0269 | gene:17574854 | gene:17574088 | Probable deoxyuridine triphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Putative F420-dependent glucose-6-phosphate dehydrogenase; Catalyzes the coenzyme F420-dependent oxidation of glucose 6- phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. | 0.734 |
dut | ML1027 | gene:17574854 | gene:17574853 | Probable deoxyuridine triphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Possible membrane protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49991 (EMBL:U15181) (157 aa); Fasta score E(): 0, 99.4% identity in 157 aa overlap. Also highly similar to proteins of unknown function from Mycobacterium tuberculosis Rv2698 TR:O07200 (EMBL:Z96072) (161 aa); Fasta score E(): 0, 78.9% identity in 161 aa overlap and Streptomyces coelicolor TR:O54132 (EMBL:AL021530) (154 aa); Fasta score E(): 1.1e-08, 33.6% identity in 149 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains a probable helix-turn-helix m [...] | 0.757 |
dut | ML1029 | gene:17574854 | gene:17574855 | Probable deoxyuridine triphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49993 (EMBL:U15181) (273 aa); Fasta score E(): 0, 99.6% identity in 273 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2696c TR:O07198 (EMBL:Z96072) (259 aa); Fasta score E(): 0, 70.6% identity in 262 aa overlap. | 0.859 |
dut | ML1514 | gene:17574854 | gene:17575355 | Probable deoxyuridine triphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Putative mycobacteriophage protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.988 |
dut | ML2507 | gene:17574854 | gene:17576371 | Probable deoxyuridine triphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Probable deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.922 |
dut | dnaN | gene:17574854 | gene:17573811 | Probable deoxyuridine triphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | 0.730 |
dut | ndk | gene:17574854 | gene:17575307 | Probable deoxyuridine triphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.944 |