STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ML1137Possible glycosyltransferase; Involved in the biosynthesis of the disaccharide D-N- acetylglucosamine-L-rhamnose which plays an important role in the mycobacterial cell wall as a linker connecting arabinogalactan and peptidoglycan via a phosphodiester linkage. Catalyzes the transfer of the N-acetylglucosamine-1-phosphate (GlcNAc-1P) moiety from UDP-GlcNAc onto the carrier lipid decaprenyl phosphate (C50-P), yielding GlcNAc- pyrophosphoryl-decaprenyl (GlcNAc-PP-C50) (By similarity). (399 aa)    
Predicted Functional Partners:
wbbL
Similar to Mycobacterium tuberculosis putative dTDP-rhamnosyl transferase RV3265C OR MTCY71.05C TR:P96870 (EMBL:Z92771) fasta scores: E(): 0, 84.7% id in 301 aa, and to Mycobacterium smegmatis dTDP-rha:A-D-GlcNAc-diphosphoryl polyprenol, A-3-L-rhamnosyl transferase wbbL TR:Q9RN50 (EMBL:AF187550) fasta scores: E(): 0, 69.9% id in 296 aa. Contains Pfam match to entry PF00535 Glycos_transf_2, Glycosyl transferases.
 
 
 0.963
ML1136
Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.
       0.808
ML1135
Possible protoporphyrinogen oxidase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
  
    0.757
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
       0.754
rfbE
Similar to M. tuberculosis Rv3782, putative glycosyl transferase, TR:P72048. Shows very weak similarity to proteins involved in lipopolysaccharide biosynthesis.
  
  
 0.746
rmlB
Similar to M. tuberculosis dTDP-glucose 4,6-dehydratase rmlB Rv3464 TR:O06329 (EMBL:Z95390) (331 aa); Fasta score E(): 0, 84.0% identity in 331 aa overlap, and TR:Q50556 (EMBL:U43540) (329 aa); Fasta score E(): 0, 78.2% identity in 331 aa overlap, and to others e.g. Streptococcus pneumoniae DTDP-glucose-4,6-dehydratase cpsN TR:O54611 (EMBL:AF030364) (349 aa); Fasta score E(): 0, 59.9% identity in 334 aa overlap. Contains Pfam match to entry PF01370 Epimerase, NAD dependent epimerase/dehydratase family; Similar to ML0204, ML0751, ML1942 and ML2428.
  
  
 0.735
rpmE
50S ribosomal protein L31; Binds the 23S rRNA.
       0.676
ML0093
Similar to M. tuberculosis Rv3808c, hypothetical protein, TR:O53585 (EMBL:AL123456) (637 aa); Fasta score E(): 0, 85.4% identity in 643 aa overlap.
  
  
 0.666
atpH
Bi-domained ATP synthase B, [Delta] chain protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity).
  
    0.656
rodA
Similar to M. tuberculosis ftsW, cell-division protein, SW:FTSW_MYCTU (P71587) (469 aa); Fasta score E(): 0, 82.3% identity in 469 aa overlap and to Streptomyces coelicolor ftsW, cell-division protein, TR:Q9ZBA6 (EMBL:AL109663) (456 aa); Fasta score E(): 3.3e-25, 32.1% identity in 377 aa overlap. Previously sequenced as SW:FTSW_MYCLE (Q50186) (465 aa); Fasta score E(): 0, 99.6% identity in 465 aa overlap. Contains hydrophobic, possible membrane-spanning regions. Contains Pfam match to entry PF01098 FTSW_RODA_SPOVE, Cell cycle protein. Contains PS00428 Cell cycle proteins ftsW / rodA / [...]
 
  
 0.644
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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