node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML1079 | ML1171 | gene:17574905 | gene:17575001 | Possible secreted protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. | Possible conserved integral membrane protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD37_MYCLE (P53426) (251 aa); Fasta score E(): 0, 100.0% identity in 238 aa overlap. Also highly similar to other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1337 SW:YD37_MYCTU (Q10647) (240 aa); Fasta score E(): 0, 73.2% identity in 231 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01694 Rhomboid, Rhomboid family. | 0.643 |
ML1079 | ML1331 | gene:17574905 | gene:17575165 | Possible secreted protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. | Possible secreted protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.956 |
ML1166 | ML1171 | gene:17574996 | gene:17575001 | Conserved hypothetical protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD32_MYCLE (P53424) (222 aa); Fasta score E(): 0, 100.0% identity in 195 aa overlap. Also highly similar to proteins of undefined function from Mycobacterium tuberculosis Rv1332 SW:YD32_MYCTU (Q10643) (218 aa); Fasta score E(): 0, 74.4% identity in 195 aa overlap and Streptomyces coelicolor TR:Q9S2G6 (EMBL:AL096852) (202 aa); Fasta score E(): 1.5e-05, 34.6% identity in 188 aa overlap; To M.tuberculosis Rv1332. | Possible conserved integral membrane protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD37_MYCLE (P53426) (251 aa); Fasta score E(): 0, 100.0% identity in 238 aa overlap. Also highly similar to other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1337 SW:YD37_MYCTU (Q10647) (240 aa); Fasta score E(): 0, 73.2% identity in 231 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01694 Rhomboid, Rhomboid family. | 0.638 |
ML1166 | ML1173 | gene:17574996 | gene:17575003 | Conserved hypothetical protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD32_MYCLE (P53424) (222 aa); Fasta score E(): 0, 100.0% identity in 195 aa overlap. Also highly similar to proteins of undefined function from Mycobacterium tuberculosis Rv1332 SW:YD32_MYCTU (Q10643) (218 aa); Fasta score E(): 0, 74.4% identity in 195 aa overlap and Streptomyces coelicolor TR:Q9S2G6 (EMBL:AL096852) (202 aa); Fasta score E(): 1.5e-05, 34.6% identity in 188 aa overlap; To M.tuberculosis Rv1332. | Conserved hypothetical protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD39_MYCLE (P50474) (284 aa); Fasta score E(): 0, 100.0% identity in 260 aa overlap. Also highly similar to several other proteins of unknown function e.g. Mycobacterium tuberculosis Rv1339 SW:YD39_MYCTU and Streptomyces coelicolor TR:Q9S2H3 (EMBL:AL096852) (250 aa); Fasta score E(): 0, 43.0% identity in 256 aa overlap; Belongs to the AtsA family. | 0.493 |
ML1166 | murI | gene:17574996 | gene:17575002 | Conserved hypothetical protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD32_MYCLE (P53424) (222 aa); Fasta score E(): 0, 100.0% identity in 195 aa overlap. Also highly similar to proteins of undefined function from Mycobacterium tuberculosis Rv1332 SW:YD32_MYCTU (Q10643) (218 aa); Fasta score E(): 0, 74.4% identity in 195 aa overlap and Streptomyces coelicolor TR:Q9S2G6 (EMBL:AL096852) (202 aa); Fasta score E(): 1.5e-05, 34.6% identity in 188 aa overlap; To M.tuberculosis Rv1332. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.493 |
ML1171 | ML1079 | gene:17575001 | gene:17574905 | Possible conserved integral membrane protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD37_MYCLE (P53426) (251 aa); Fasta score E(): 0, 100.0% identity in 238 aa overlap. Also highly similar to other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1337 SW:YD37_MYCTU (Q10647) (240 aa); Fasta score E(): 0, 73.2% identity in 231 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01694 Rhomboid, Rhomboid family. | Possible secreted protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. | 0.643 |
ML1171 | ML1166 | gene:17575001 | gene:17574996 | Possible conserved integral membrane protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD37_MYCLE (P53426) (251 aa); Fasta score E(): 0, 100.0% identity in 238 aa overlap. Also highly similar to other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1337 SW:YD37_MYCTU (Q10647) (240 aa); Fasta score E(): 0, 73.2% identity in 231 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01694 Rhomboid, Rhomboid family. | Conserved hypothetical protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD32_MYCLE (P53424) (222 aa); Fasta score E(): 0, 100.0% identity in 195 aa overlap. Also highly similar to proteins of undefined function from Mycobacterium tuberculosis Rv1332 SW:YD32_MYCTU (Q10643) (218 aa); Fasta score E(): 0, 74.4% identity in 195 aa overlap and Streptomyces coelicolor TR:Q9S2G6 (EMBL:AL096852) (202 aa); Fasta score E(): 1.5e-05, 34.6% identity in 188 aa overlap; To M.tuberculosis Rv1332. | 0.638 |
ML1171 | ML1173 | gene:17575001 | gene:17575003 | Possible conserved integral membrane protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD37_MYCLE (P53426) (251 aa); Fasta score E(): 0, 100.0% identity in 238 aa overlap. Also highly similar to other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1337 SW:YD37_MYCTU (Q10647) (240 aa); Fasta score E(): 0, 73.2% identity in 231 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01694 Rhomboid, Rhomboid family. | Conserved hypothetical protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD39_MYCLE (P50474) (284 aa); Fasta score E(): 0, 100.0% identity in 260 aa overlap. Also highly similar to several other proteins of unknown function e.g. Mycobacterium tuberculosis Rv1339 SW:YD39_MYCTU and Streptomyces coelicolor TR:Q9S2H3 (EMBL:AL096852) (250 aa); Fasta score E(): 0, 43.0% identity in 256 aa overlap; Belongs to the AtsA family. | 0.621 |
ML1171 | ML1331 | gene:17575001 | gene:17575165 | Possible conserved integral membrane protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD37_MYCLE (P53426) (251 aa); Fasta score E(): 0, 100.0% identity in 238 aa overlap. Also highly similar to other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1337 SW:YD37_MYCTU (Q10647) (240 aa); Fasta score E(): 0, 73.2% identity in 231 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01694 Rhomboid, Rhomboid family. | Possible secreted protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.562 |
ML1171 | ML1802 | gene:17575001 | gene:17575649 | Possible conserved integral membrane protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD37_MYCLE (P53426) (251 aa); Fasta score E(): 0, 100.0% identity in 238 aa overlap. Also highly similar to other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1337 SW:YD37_MYCTU (Q10647) (240 aa); Fasta score E(): 0, 73.2% identity in 231 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01694 Rhomboid, Rhomboid family. | Conserved hypothetical protein; Similar to M. tuberculosis Rv1488 SW:YE88_MYCTU (P71768) (381 aa); Fasta score E(): 0, 89.8% identity in 373 aa overlap, and to many others members of the BAND 7 / MEC-2 family e.g. Streptomyces coelicolor conserved hypothetical protein SCI5.04C TR:Q9X9Z6 (EMBL:AL079332) (319 aa); Fasta score E(): 0, 54.7% identity in 311 aa overlap. Contains Pfam match to entry PF01145 Band_7, SPFH domain / Band 7 family. Contains PS00024 Hemopexin domain signature. Contains PS01270 Band 7 protein family signature. | 0.861 |
ML1171 | ML2331 | gene:17575001 | gene:17576192 | Possible conserved integral membrane protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD37_MYCLE (P53426) (251 aa); Fasta score E(): 0, 100.0% identity in 238 aa overlap. Also highly similar to other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1337 SW:YD37_MYCTU (Q10647) (240 aa); Fasta score E(): 0, 73.2% identity in 231 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01694 Rhomboid, Rhomboid family. | Possible secreted protein; Similar to Mycobacterium tuberculosis hypothetical 24.8 kDa protein Rv3717 TR:O69684 (EMBL:AL022121) (241 aa) fasta scores: E(): 0, 82.0% id in 244 aa, and to Streptomyces coelicolor putative secreted protein TR:CAB93433 (EMBL:AL357591) (336 aa) fasta scores: E(): 1.5e-24, 38.8% id in 242 aa. Note contains a Pfam match to PF01520 N-acetylmuramoyl-L-alanine amidase. Contains Pfam match to entry PF01520 Amidase_3, N-acetylmuramoyl-L-alanine amidase. Contains a possible N-terminal signal sequence. | 0.601 |
ML1171 | ML2670 | gene:17575001 | gene:17576536 | Possible conserved integral membrane protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD37_MYCLE (P53426) (251 aa); Fasta score E(): 0, 100.0% identity in 238 aa overlap. Also highly similar to other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1337 SW:YD37_MYCTU (Q10647) (240 aa); Fasta score E(): 0, 73.2% identity in 231 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01694 Rhomboid, Rhomboid family. | Conserved integral membrane protein; Similar to Mycobacterium tuberculosis putative acetyltransferase TR:O53633 (EMBL:AL021926) fasta scores: E(): 0, 78.6% in 681 aa. Also similar to Salmonella typhimurium OafA, a member of the integral membrane trans-acylases TR:P74874 (EMBL:U65941) fasta scores: E(): 7.9e-16, 25.2% in 658 aa. Contains multiple possible membrane spanning hydrophobic domains. Contains 2 Pfam matches to entry PF01757 DUF33, Domain of unknown function. | 0.798 |
ML1171 | ML2704 | gene:17575001 | gene:17576570 | Possible conserved integral membrane protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD37_MYCLE (P53426) (251 aa); Fasta score E(): 0, 100.0% identity in 238 aa overlap. Also highly similar to other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1337 SW:YD37_MYCTU (Q10647) (240 aa); Fasta score E(): 0, 73.2% identity in 231 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01694 Rhomboid, Rhomboid family. | Putative hydrolase; Similar to Mycobacterium tuberculosis putative hydrolase TR:O53593 (EMBL:AL021426) fasta scores: E(): 0, 86.9% in 406 aa. Contains 2 Pfam matches to entry PF01471 PG_binding_1, Putative peptidoglycan binding domain. Contains Pfam match to entry PF01520 Amidase_3, N-acetylmuramoyl-L-alanine amidase. | 0.538 |
ML1171 | ftsH | gene:17575001 | gene:17574039 | Possible conserved integral membrane protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD37_MYCLE (P53426) (251 aa); Fasta score E(): 0, 100.0% identity in 238 aa overlap. Also highly similar to other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1337 SW:YD37_MYCTU (Q10647) (240 aa); Fasta score E(): 0, 73.2% identity in 231 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01694 Rhomboid, Rhomboid family. | Putative integral membrane peptidase; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | 0.605 |
ML1171 | murI | gene:17575001 | gene:17575002 | Possible conserved integral membrane protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD37_MYCLE (P53426) (251 aa); Fasta score E(): 0, 100.0% identity in 238 aa overlap. Also highly similar to other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1337 SW:YD37_MYCTU (Q10647) (240 aa); Fasta score E(): 0, 73.2% identity in 231 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01694 Rhomboid, Rhomboid family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.893 |
ML1173 | ML1166 | gene:17575003 | gene:17574996 | Conserved hypothetical protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD39_MYCLE (P50474) (284 aa); Fasta score E(): 0, 100.0% identity in 260 aa overlap. Also highly similar to several other proteins of unknown function e.g. Mycobacterium tuberculosis Rv1339 SW:YD39_MYCTU and Streptomyces coelicolor TR:Q9S2H3 (EMBL:AL096852) (250 aa); Fasta score E(): 0, 43.0% identity in 256 aa overlap; Belongs to the AtsA family. | Conserved hypothetical protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD32_MYCLE (P53424) (222 aa); Fasta score E(): 0, 100.0% identity in 195 aa overlap. Also highly similar to proteins of undefined function from Mycobacterium tuberculosis Rv1332 SW:YD32_MYCTU (Q10643) (218 aa); Fasta score E(): 0, 74.4% identity in 195 aa overlap and Streptomyces coelicolor TR:Q9S2G6 (EMBL:AL096852) (202 aa); Fasta score E(): 1.5e-05, 34.6% identity in 188 aa overlap; To M.tuberculosis Rv1332. | 0.493 |
ML1173 | ML1171 | gene:17575003 | gene:17575001 | Conserved hypothetical protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD39_MYCLE (P50474) (284 aa); Fasta score E(): 0, 100.0% identity in 260 aa overlap. Also highly similar to several other proteins of unknown function e.g. Mycobacterium tuberculosis Rv1339 SW:YD39_MYCTU and Streptomyces coelicolor TR:Q9S2H3 (EMBL:AL096852) (250 aa); Fasta score E(): 0, 43.0% identity in 256 aa overlap; Belongs to the AtsA family. | Possible conserved integral membrane protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD37_MYCLE (P53426) (251 aa); Fasta score E(): 0, 100.0% identity in 238 aa overlap. Also highly similar to other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1337 SW:YD37_MYCTU (Q10647) (240 aa); Fasta score E(): 0, 73.2% identity in 231 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01694 Rhomboid, Rhomboid family. | 0.621 |
ML1173 | murI | gene:17575003 | gene:17575002 | Conserved hypothetical protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD39_MYCLE (P50474) (284 aa); Fasta score E(): 0, 100.0% identity in 260 aa overlap. Also highly similar to several other proteins of unknown function e.g. Mycobacterium tuberculosis Rv1339 SW:YD39_MYCTU and Streptomyces coelicolor TR:Q9S2H3 (EMBL:AL096852) (250 aa); Fasta score E(): 0, 43.0% identity in 256 aa overlap; Belongs to the AtsA family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.621 |
ML1331 | ML1079 | gene:17575165 | gene:17574905 | Possible secreted protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | Possible secreted protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. | 0.956 |
ML1331 | ML1171 | gene:17575165 | gene:17575001 | Possible secreted protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | Possible conserved integral membrane protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD37_MYCLE (P53426) (251 aa); Fasta score E(): 0, 100.0% identity in 238 aa overlap. Also highly similar to other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1337 SW:YD37_MYCTU (Q10647) (240 aa); Fasta score E(): 0, 73.2% identity in 231 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01694 Rhomboid, Rhomboid family. | 0.562 |