STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ansAL-asparaginase/L-glutaminase; Identical to the previously sequenced Mycobacterium leprae probable L-asparaginase (EC 3.5.1.1) SW:ASPG_MYCLE (Q9X7E6) (310 aa); Fasta score E(): 0, 100.0% identity in 310 aa overlap. Also highly similar to many other L-asparaginases e.g. Mycobacterium tuberculosis Rv1538c SW:ASPG_MYCTU (Q10759) (315 aa); Fasta score E(): 0, 72.4% identity in 315 aa overlap and Saccharomyces cerevisiae SW:ASG1_YEAST (P38986) (381 aa); Fasta score E(): 6.4e-12, 27.5% identity in 327 aa overlap. Contains Pfam match to entry PF00710 Asparaginase, Asparaginase. Contains PS0091 [...] (310 aa)    
Predicted Functional Partners:
asnB
Similar to Mycobacterium tuberculosis putative asparagine synthetase [glutamine-hydrolyzing] Rv2201 or mtcy190.12 SW:ASNH_MYCTU (Q10374) (652 aa) fasta scores: E(): 0, 83.3% id in 659 aa and to Bacillus subtilis asparagine synthetase [glutamine-hydrolyzing] 1 asnB or asn SW:ASNB_BACSU (P54420; O34902) (632 aa) fasta scores: E(): 0, 49.0% id in 614 aa. Contains Pfam match to entry PF00310 GATase_2, Glutamine amidotransferases class-II. Contains Pfam match to entry PF00733 Asn_synthase, Asparagine synthase.
     
 0.908
nadB
L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.
   
 
 0.908
argG
Arginosuccinate synthase; Highly similar to many argininosuccinate synthases (EC 6.3.4.5) involved in arginine biosynthesis, including: Streptomyces clavuligerus SW:ASSY_STRCL (P50986) (397 aa); Fasta score E(): 0, 67.0% identity in 397 aa overlap and Mycobacterium tuberculosis SW:ASSY_MYCTU (P94993) (398 aa); Fasta score E(): 0, 91.0% identity in 398 aa overlap. Contains Pfam match to entry PF00764 Arginosuc_synth, Arginosuccinate synthase. Contains PS00564 Argininosuccinate synthase signature 1. Contains PS00565 Argininosuccinate synthase signature 2.
   
 
 0.906
purA
Putative adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
     
  0.900
pyrB
Similar to M. tuberculosis pyrB, Rv1380, aspartate carbamoyltransferase, SW:PYRB_MYCTU (P71808) (319 aa); Fasta score E(): 0, 89.9% identity in 318 aa overlap. Similar to many e.g. Pseudomonas putida, aspartate carbamoyltransferase, SW:PYRB_PSEPU (Q59711) (334 aa); Fasta score E(): 0, 47.3% identity in 317 aa overlap. Contains 2 Pfam matches to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase. Contains PS00097 Aspartate and ornithine carbamoyltransferases signature; Shows weak similarity to ML1410; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCas [...]
     
  0.900
panD
Putative aspartate-1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
     
 0.864
ansP1
Probable L-asparagine permease; Highly similar to many L-asparagine transport proteins including: Salmonella typhimurium AnsP SW:ANSP_SALTY (P40812) (497 aa); Fasta score E(): 0, 58.7% identity in 477 aa overlap and Mycobacterium tuberculosis RV2127 SW:ANSP_MYCTU (O33261) (489 aa); Fasta score E(): 0, 83.4% identity in 488 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00324 aa_permeases, Amino acid permease. Contains PS00218 Amino acid permeases signature; Almost identical to the duplicated sequence ML1305.
     
 0.841
ask
Aspartokinase; Similar to Mycobacterium tuberculosis aspartokinase ask or rv3709c or mtv025.057C SW:AK_MYCTU (P97048; O69676; P97181) (421 aa) fasta scores: E(): 0, 92.6% id in 421 aa, and to Mycobacterium smegmatis aspartokinase asK SW:AK_MYCSM (P41403) (421 aa) fasta scores: E(): 0, 85.3% id in 421 aa. Contains Pfam match to entry PF00696 aakinase, Amino acid kinase family. Contains Pfam match to entry PF01842 ACT, ACT domain. Contains PS00324 Aspartokinase signature.
     
 0.806
lspA
Lipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family.
     
 0.762
ML1200
Putative pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.
       0.662
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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