node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML1463 | bioA | gene:17575301 | gene:17575047 | Possible NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.861 |
ML1463 | bioB | gene:17575301 | gene:17575051 | Possible NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.790 |
ML1463 | birA | gene:17575301 | gene:17574556 | Possible NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Biotin apo-protein ligase; Similar to Mycobacterium tuberculosis birA OR RV3279C OR MTCY71.19C TR:P96884 (EMBL:Z92771) fasta scores: E(): 0, 71.2% id in 271 aa, and to Escherichia coli birA bifunctional protein [includes: biotin operon repressor; biotin--[acetyl-coa-carboxylase] synthetase birA OR bioR OR dhbB SW:BIRA_ECOLI (P06709) fasta scores: E(): 2e-10, 31.3% id in 256 aa. Lacks the N-terminal helix-turn-helix domain, so may not act as a repressor. Contains Pfam match to entry PF01317 BPL, Biotin protein ligase. | 0.796 |
ML1463 | panC | gene:17575301 | gene:17574047 | Possible NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Putative pantoate-[beta]-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.666 |
ML1463 | ribA | gene:17575301 | gene:17574380 | Possible NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Putative GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.826 |
ML1612 | bioA | gene:17575453 | gene:17575047 | Similar in parts to many proposed signal peptidases e.g. Bacillus subtilis SW:LEPT_BACSU (P71013) (193 aa); Fasta score E(): 1.1e-07, 31.0% identity in 226 aa overlap and Mycobacterium tuberculosis RV2903C SW:LEP_MYCTU (Q1078) (294 aa); Fasta score E(): 0, 69.8% identity in 301 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF00461 Peptidase_S26, Signal peptidase I. Contains PS00501 Signal peptidases I serine active site. Contains PS00761 Signal peptidases I signature 3. | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.579 |
ML1612 | panC | gene:17575453 | gene:17574047 | Similar in parts to many proposed signal peptidases e.g. Bacillus subtilis SW:LEPT_BACSU (P71013) (193 aa); Fasta score E(): 1.1e-07, 31.0% identity in 226 aa overlap and Mycobacterium tuberculosis RV2903C SW:LEP_MYCTU (Q1078) (294 aa); Fasta score E(): 0, 69.8% identity in 301 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF00461 Peptidase_S26, Signal peptidase I. Contains PS00501 Signal peptidases I serine active site. Contains PS00761 Signal peptidases I signature 3. | Putative pantoate-[beta]-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.708 |
aceA | bioA | gene:17575837 | gene:17575047 | Isocitrate lyase; Involved in the persistence and virulence of Mycobacterium. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.481 |
bioA | ML1463 | gene:17575047 | gene:17575301 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Possible NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.861 |
bioA | ML1612 | gene:17575047 | gene:17575453 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Similar in parts to many proposed signal peptidases e.g. Bacillus subtilis SW:LEPT_BACSU (P71013) (193 aa); Fasta score E(): 1.1e-07, 31.0% identity in 226 aa overlap and Mycobacterium tuberculosis RV2903C SW:LEP_MYCTU (Q1078) (294 aa); Fasta score E(): 0, 69.8% identity in 301 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF00461 Peptidase_S26, Signal peptidase I. Contains PS00501 Signal peptidases I serine active site. Contains PS00761 Signal peptidases I signature 3. | 0.579 |
bioA | aceA | gene:17575047 | gene:17575837 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Isocitrate lyase; Involved in the persistence and virulence of Mycobacterium. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates. | 0.481 |
bioA | bioB | gene:17575047 | gene:17575051 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.997 |
bioA | bioD | gene:17575047 | gene:17575049 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.999 |
bioA | bioF | gene:17575047 | gene:17575048 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.999 |
bioA | birA | gene:17575047 | gene:17574556 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Biotin apo-protein ligase; Similar to Mycobacterium tuberculosis birA OR RV3279C OR MTCY71.19C TR:P96884 (EMBL:Z92771) fasta scores: E(): 0, 71.2% id in 271 aa, and to Escherichia coli birA bifunctional protein [includes: biotin operon repressor; biotin--[acetyl-coa-carboxylase] synthetase birA OR bioR OR dhbB SW:BIRA_ECOLI (P06709) fasta scores: E(): 2e-10, 31.3% id in 256 aa. Lacks the N-terminal helix-turn-helix domain, so may not act as a repressor. Contains Pfam match to entry PF01317 BPL, Biotin protein ligase. | 0.718 |
bioA | panC | gene:17575047 | gene:17574047 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Putative pantoate-[beta]-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.678 |
bioA | prcB | gene:17575047 | gene:17575156 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Proteasome [beta]-type subunit 2; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.488 |
bioA | ribA | gene:17575047 | gene:17574380 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Putative GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.472 |
bioB | ML1463 | gene:17575051 | gene:17575301 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Possible NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.790 |
bioB | bioA | gene:17575051 | gene:17575047 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.997 |