STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (345 aa)    
Predicted Functional Partners:
bioD
Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
 
 0.999
bioA
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
  
 0.997
bioF
8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
  
 0.989
birA
Biotin apo-protein ligase; Similar to Mycobacterium tuberculosis birA OR RV3279C OR MTCY71.19C TR:P96884 (EMBL:Z92771) fasta scores: E(): 0, 71.2% id in 271 aa, and to Escherichia coli birA bifunctional protein [includes: biotin operon repressor; biotin--[acetyl-coa-carboxylase] synthetase birA OR bioR OR dhbB SW:BIRA_ECOLI (P06709) fasta scores: E(): 2e-10, 31.3% id in 256 aa. Lacks the N-terminal helix-turn-helix domain, so may not act as a repressor. Contains Pfam match to entry PF01317 BPL, Biotin protein ligase.
  
 
 0.980
ML1221
Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49616 (EMBL:U00010) (80 aa); Fasta score E(): 0, 98.8% identity in 80 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv1590 TR:O06600 (EMBL:Z95586) (79 aa); Fasta score E(): 3.4e-21, 67.1% identity in 73 aa overlap; To M.tuberculosis Rv1590.
 
  
 0.906
ML1222
Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49626 (EMBL:U00010) (198 aa); Fasta score E(): 0, 99.5% identity in 198 aa overlap. Highly similar to proteins of undefined function also found downstream of BioB orthologues in Mycobacterium tuberculosis Rv1591 TR:O06599 (EMBL:Z95586) (221 aa); Fasta score E(): 0, 63.8% identity in 188 aa overlap and Mycobacterium bovis BCG TR:O52590 (EMBL:AF041819) (193 aa); Fasta score E(): 0, 67.6% identity in 170 aa overlap.
  
    0.826
ML1463
Possible NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
     
 0.790
metK
Putative S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
      
 0.720
fprA
Putative NADPH-ferredoxin reductase; May serve as electron transfer protein and supply electrons to P450 systems; Belongs to the ferredoxin--NADP reductase type 1 family.
     
 0.623
ribA
Putative GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
      
 0.470
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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