STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ML1241Possible enoyl-CoA hydratase/isomerase; Could possibly oxidize fatty acids using specific components. (294 aa)    
Predicted Functional Partners:
fadB2
3-hydroxyacyl-CoA dehydrogenase; Similar to Mycobacterium tuberculosis putative 3-hydroxyacyl-CoA dehydrogenase Rv0468 TR:O53753 (EMBL:AL021933) fasta scores: E(): 0, 89.5% id in 287 aa, and to Clostridium acetobutylicum 3-hydroxybutyryl-CoA dehydrogenase SW:HBD_CLOAB (P52041) fasta scores: E(): 0, 43.3% id in 282 aa. Contains Pfam match to entry PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase.
 0.982
fadE23
Putative acyl-CoA dehydrogenase; Similar to M. tuberculosis fadE23, Rv3140, acyl-CoA dehydrogenase, TR:P95186 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 89.5% identity in 401 aa overlap. Similar to many e.g. Homo sapiens acadS, acyl-coa dehydrogenase, short-chain specific precursor, SW:ACDS_HUMAN (P16219) (412 aa); Fasta score E(): 4.1e-31, 31.8% identity in 393 aa overlap. Previously sequenced as TR:O32891 (EMBL:Z98271) (400 aa); Fasta score E(): 0, 100.0% identity in 400 aa overlap. Contains 2 Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase; Similar to ML0737.
   
 0.959
fadB
Putative fatty oxidation complex alpha subunit; Similar to Mycobacterium tuberculosis hypothetical 76.1 kda protein TR:O53872 (EMBL:AL022004) fasta scores: E(): 0, 88.6% in 719 aa, and to Escherichia coli fatty oxidation complex alpha subunit SW:FADB_ECOLI (P21177) fasta scores: E(): 0, 33.0% in 684 aa. Contains Pfam match to entry PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family; Similar to ML1724, ML2402, ML2401, ML1241 and ML2118.
 
0.922
fadE25
Putative acyl-CoA dehydrogenase; Similar to Mycobacterium tuberculosis RV3274C OR MTCY71.14C, putative acyl-CoA dehydrogenase, TR:P96879 (EMBL:Z92771) fasta scores: E(): 0, 92.0% id in 389 aa, and to Streptomyces lividans fatty acid acyl-CoA dehydrogenase fadE TR:Q9RIQ5 (EMBL:AJ250495) fasta scores: E(): 0, 67.6% id in 383 aa. Previously sequenced as SW:ACD_MYCLE (P46703). Contains Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. Contains PS00073 Acyl-CoA dehydrogenases signature 2. Contains PS00072 Acyl-CoA dehydrogenases signature 1; Similar to ML0660, ML0661 and show [...]
   
 0.858
fadE5
acyl-CoA dehydrogenase; Similar to Mycobacterium tuberculosis putative acyl-CoA dehydrogenase RV0244C TR:O53666 (EMBL:AL021929) fasta scores: E(): 0, 89.4% id in 611 aa. Contains 2 Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase.
   
 0.842
fadA2
acetyl-CoA C-acetyltransferase; Similar to many Prokaryotic and Eukaryotic thiolases including: Escherichia coli probable 3-ketoacyl-coa thiolase YFCY SW:YFCY_ECOLI (P76503) fasta scores: E(): 0, 36.9% id in 434 aa and to Rattus norvegicus trifunctonal enzyme beta subunit, mitochondrial precursor SW:ECHB_RAT (Q60587) fasta scores: E(): 0, 37.2% id in 462 aa. Contains Pfam match to entry PF00108 thiolase, Thiolase. Contains PS00099 Thiolases active site; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.809
fadE24
Putative acyl-CoA dehydrogenase; Similar to M. tuberculosis fadE24, Rv3139, acyl-CoA dehydrogenase, TR:P95187 (EMBL:AL123456) (468 aa); Fasta score E(): 0, 83.6% identity in 464 aa overlap. Similar to many e.g. Streptomyces lividans fadE, fatty acid acyl-CoA dehydrogenase, TR:Q9RIQ5 (EMBL:AJ250495) (385 aa); Fasta score E(): 5.1e-27, 28.5% identity in 376 aa overlap. Previously sequenced as TR:O32890 (EMBL:Z98271) (465 aa); Fasta score E(): 0, 100.0% identity in 465 aa overlap. Contains 2 Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. Contains PS00073 Acyl-CoA dehyd [...]
   
 0.788
fas
Fatty acid synthase; Identical to the previously sequenced Mycobacterium leprae putative type I fatty acid synthase TR:Q9X7E2 (EMBL:AL049478) (3076 aa); Fasta score E(): 0, 100.0% identity in 3076 aa overlap. Also highly similar to many other fatty acid synthases including: Mycobacterium tuberculosis Rv2524c TR:P95029 (EMBL:Z83863) (3069 aa); Fasta score E(): 0, 85.8% identity in 3081 aa overlap and Corynebacterium ammoniagenes fatty-acid synthase (EC 2.3.1.85) TR:Q59497 (EMBL:X87822) (3063 aa); Fasta score E(): 0, 44.3% identity in 3106 aa overlap. Contains Pfam match to entry PF00109 [...]
  
 0.761
fadA4
Possible acetyl-CoA C-acetyltransferase; Identical to the previously sequenced Mycobacterium leprae probable acetyl-CoA acetyltransferase (EC 2.3.1.9) SW:THIL_MYCLE (P46707) (393 aa); Fasta score E(): 0, 100.0% identity in 393 aa overlap. Also highly similar to many others including: acetyl-CoA acetyltransferases from Alcaligenes eutrophus SW:THIL_ALCEU (P14611) (393 aa); Fasta score E(): 0, 50.4% identity in 389 aa overlap and Mycobacterium tuberculosis (FadA4) Rv1323 SW:THIL_MYCTU (Q10629) (389 aa); Fasta score E(): 0, 86.9% identity in 388 aa overlap. Contains Pfam match to entry PF [...]
  
 0.757
fadA
Similar to Mycobacterium tuberculosis putative beta-ketoadipyl CoA thiolase TR:O53871 (EMBL:AL022004) fasta scores: E(): 0, 94.5% in 403 aa, and to Escherichia coli acetyl-coa acetyltransferase TR:O53017 (EMBL:X97452) fasta scores: E(): 0, 44.1% in 422 aa, and to Acinetobacter calcoaceticus beta-ketoadipyl coa thiolase SW:PCAF_ACICA (Q43974) fasta scores: E(): 0, 40.9% in 425 aa. Contains Pfam match to entry PF00108 thiolase, Thiolase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00098 Thiolases acyl-enzyme intermediate signature. Contains PS00099 Thiolases active [...]
  
 0.757
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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