STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
plsBHighly similar to many acyltransferases including: Escherichia coli glycerol-3-phosphate acyltransferase (EC 2.3.1.15) SW:PLSB_ECOLI (P00482) (806 aa); Fasta score E(): 1.5e-27, 24.4% identity in 693 aa overlap and Mycobacterium tuberculosis putative acyltransferase PlsB2 (RV2482C) SW:PLS2_MYCTU (O53207) (789 aa); Fasta score E(): 0, 80.7% identity in 783 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase, Acyltransferase; Belongs to the GPAT/DAPAT family. (775 aa)    
Predicted Functional Partners:
ML1245
Possible transferase; The N-terminus is similar to several phosphoserine phosphatases e.g. Haemophilus influenzae SW:SERB_HAEIN (P44997) (795 aa); BlastP Expect 9.8 and the C-terminus is similar to many Prokaryotic and Eukaryotic acyltransferases e.g. Salmonella typhimurium 1-acyl-SN-glycerol-3-phosphate acyltransferase (EC 2.3.1.51) SW:PLSC_SALTY (P26974) (245 aa); Fasta score E(): 1.4e-11, 35.3% identity in 167 aa overlap. Highly similar over entire protein to Mycobacterium tuberculosis putative transferase Rv2483c TR:O53208 (EMBL:AL021246) (580 aa); Fasta score E(): 0, 77.1% identit [...]
 
 
 0.994
ML1244
Conserved membrane protein; Highly similar to a family of Mycobacterium tuberculosis proteins e.g. Rv2484c SW:YO84_MYCTU (O53209) (491 aa); Fasta score E(): 0, 75.2% identity in 483 aa overlap. Contains possible membrane spanning hydrophobic domains; Belongs to the long-chain O-acyltransferase family.
 
  
 0.978
glpD
Similar to M. tuberculosis glpD2, Rv3302c, glycerol-3-phosphate dehydrogenase, TR:O07168 (EMBL:AL123456) (585 aa); Fasta score E(): 0, 90.8% identity in 584 aa overlap. Similar to many e.g. Escherichia coli, glpD, glycerol-3-phosphate dehydrogenase, SW:GLPD_ECOLI (P13035) (501 aa); Fasta score E(): 0, 35.2% identity in 492 aa overlap. Also similar to Brucella abortus eriB, erythritol phosphate dehydrogenase, TR:Q9ZB31 (EMBL:U57100) (502 aa); Fasta score E(): 0, 35.4% identity in 483 aa overlap. Previously sequenced as SW:GLPD_MYCLE (P53435) (585 aa); Fasta score E(): 0, 99.8% identity [...]
     
 0.968
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
     
 0.920
gpdA
Highly similar to many glycerol-3-phosphate dehydrogenases (EC 1.1.1.8) including: Escherichia coli SW:GPDA_ECOLI (P37606) (339 aa); Fasta score E(): 0, 39.9% identity in 341 aa overlap and Mycobacterium tuberculosis RV2982C TR:P95113 (EMBL:Z83018) (334 aa); Fasta score E(): 0, 77.9% identity in 349 aa overlap. Contains Pfam match to entry PF01210 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase.
    
 0.912
ML0892
Possible acyltransferase; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O69572 (EMBL:AL022602) (244 aa); Fasta score E(): 0, 100.0% identity in 244 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2182c TR:O53516 (EMBL:AL021957) (247 aa); Fasta score E(): 0, 79.8% identity in 247 aa overlap and several Streptomyces coelicolor putative acyltransferases e.g. TR:CAB76086 (EMBL:AL157956) (223 aa); Fasta score E(): 0, 51.1% identity in 221 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase, Acyltransferase.
  
 
 0.910
pssA
Similar to M. tuberculosis pssA, Rv0436c, CDP-diacylglycerol-serine o-phosphatidyltransferase, SW:PSS_MYCTU (P96282) (286 aa); Fasta score E(): 0, 77.9% identity in 285 aa overlap. Similar to many e.g. Helicobacter pylori pssA, CDP-diacylglycerol-serine o-phosphatidyltransferase, SW:PSS_HELPY (Q48269) (237 aa); Fasta score E(): 2.3e-14, 34.6% identity in 234 aa overlap. Previously sequenced as TR:Q9ZBM2 (EMBL:AL035159) (300 aa); Fasta score E(): 0, 100.0% identity in 300 aa overlap. Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. Contains PS00 [...]
      
 0.782
lipG
Probable hydrolase; Similar to M. tuberculosis putative hydrolase Rv0646c TR:P96935 (EMBL:Z92772) (301 aa); Fasta score E(): 0, 71.3% identity in 303 aa overlap, and to others e.g. Escherichia coli macrolide 2'-phosphotransferase II TR:P77026 (EMBL:D85892) (279 aa); Fasta score E(): 1.3e-15, 31.3% identity in 291 aa overlap, and Streptomyces peucetius 10-carbomethoxy-13-deoxycarminomycin esterase TR:Q54809 (EMBL:L40425) (298 aa); Fasta score E(): 1e-09, 28.6% identity in 301 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold; Similar to and ML0862.
  
   
 0.748
fas
Fatty acid synthase; Identical to the previously sequenced Mycobacterium leprae putative type I fatty acid synthase TR:Q9X7E2 (EMBL:AL049478) (3076 aa); Fasta score E(): 0, 100.0% identity in 3076 aa overlap. Also highly similar to many other fatty acid synthases including: Mycobacterium tuberculosis Rv2524c TR:P95029 (EMBL:Z83863) (3069 aa); Fasta score E(): 0, 85.8% identity in 3081 aa overlap and Corynebacterium ammoniagenes fatty-acid synthase (EC 2.3.1.85) TR:Q59497 (EMBL:X87822) (3063 aa); Fasta score E(): 0, 44.3% identity in 3106 aa overlap. Contains Pfam match to entry PF00109 [...]
     
 0.664
ML0109
Similar to M. tuberculosis Rv3790, putative oxidoreductase, TR:P72056 (EMBL:AL123456) (461 aa); Fasta score E(): 0, 86.6% identity in 461 aa overlap. Also similar to many bacterial putative oxidoreductases. Contains Pfam match to entry PF01565 FAD_binding_4, FAD binding domain.
    
 0.629
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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