STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurrence
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[Homology]
Score
ML1301Possible inositol monophosphatase family protein; Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'- phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I-1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F-6-P)) and AMP in vitro, but this might [...] (271 aa)    
Predicted Functional Partners:
suhB
Putative inositol monophosphatase; Identical to the previously sequenced Mycobacterium leprae extragenic suppressor protein SuhB homologue SW:SUHB_MYCLE (P46813) (291 aa); Fasta score E(): 0, 99.7% identity in 291 aa overlap. Also highly similar to many other members of the inositol monophosphatase family including: Mycobacterium tuberculosis, Rv2701c or ShuB, SW:SUHB_MYCTU (O07203) (290 aa); Fasta score E(): 0, 77.6% identity in 294 aa overlap and Escherichia coli ShuB, SW:SUHB_ECOLI (P22783) (267 aa); Fasta score E(): 1.6e-18, 34.7% identity in 239 aa overlap, shown to suppress the e [...]
 
   
 0.806
ML1300
Conserved hypothetical protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV2133C TR:O06242 (EMBL:Z95388) (262 aa); Fasta score E(): 0, 79.4% identity in 262 aa overlap.
       0.796
ML1299
Conserved hypothetical protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV2134C TR:O06241 (EMBL:Z95388) (195 aa); Fasta score E(): 0, 91.1% identity in 192 aa overlap.
       0.789
cysS2
cysteinyl-tRNA synthase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
     
 0.765
ML1297
Possible undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family.
  
    0.709
ML1298
Conserved hypothetical protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV2135C TR:O06240 (EMBL:Z95388) (236 aa); Fasta score E(): 0, 75.2% identity in 250 aa overlap. Also similar, in regions, to several putative phosphoglycerate mutases e.g. Escherichia coli SW:PMG2_ECOLI (P36942) (215 aa); Fasta score E(): 1.2e-06, 27.1% identity in 192 aa overlap. Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family.
     
 0.709
ML1946
Conserved hypothetical protein; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate.
      
 0.703
ML1296
Similar to Mycobacterium tuberculosis hypothetical protein RV2137C TR:O06238 (EMBL:Z95388) (137 aa); Fasta score E(): 1.3e-28, 75.5% identity in 106 aa overlap.
       0.655
ML0427
Putative oligoribonuclease; 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family.
      
 0.596
ML0662
Similar to M. tuberculosis Rv3137, putative monophosphatase, TR:P95189 (EMBL:AL123456) (260 aa); Fasta score E(): 0, 81.8% identity in 253 aa overlap. Similar to putative N-amidino-scyllo-inosamine-4-phosphate phosphatases from Streptomyces spp. e.g. Streptomyces glaucescens strO, TR:P72460 (EMBL:Y08764) (256 aa); Fasta score E(): 9.8e-19, 36.2% identity in 229 aa overlap. Previously sequenced as TR:O32889 (EMBL:Z98271) (255 aa); Fasta score E(): 0, 100.0% identity in 255 aa overlap. Contains 2 Pfam matches to entry PF00459 inositol_P, Inositol monophosphatase family. Contains PS00629 [...]
 
   
 0.474
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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