node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML0901 | glyA | gene:17574727 | gene:17575805 | Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O69565 (EMBL:AL022602) (304 aa); Fasta score E(): 0, 99.7% identity in 304 aa overlap(EMBL:AL022602). Also highly similar to Mycobacterium tuberculosis hypothetical protein TR:O53506 (EMBL:AL021957) (301 aa); Fasta score E(): 0, 80.9% identity in 299 aa overlap(EMBL:AL021957). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.408 |
ML0901 | hom | gene:17574727 | gene:17574956 | Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O69565 (EMBL:AL022602) (304 aa); Fasta score E(): 0, 99.7% identity in 304 aa overlap(EMBL:AL022602). Also highly similar to Mycobacterium tuberculosis hypothetical protein TR:O53506 (EMBL:AL021957) (301 aa); Fasta score E(): 0, 80.9% identity in 299 aa overlap(EMBL:AL021957). | Homoserine dehydrogenase; Identical to the previously sequenced Mycobacterium leprae homoserine dehydrogenase (EC 1.1.1.3) SW:DHOM_MYCLE (P46806) (441 aa); Fasta score E(): 0, 99.8% identity in 441 aa overlap. Also highly similar to orthologues from Mycobacterium tuberculosis SW:DHOM_MYCTU (Q10601) (441 aa); Fasta score E(): 0, 89.5% identity in 438 aa overlap and Corynebacterium glutamicum SW:DHOM_CORGL (P08499) (445 aa); Fasta score E(): 0, 60.3% identity in 431 aa overlap. Contains Pfam match to entry PF00742 Homoserine_dh, Homoserine dehydrogenase. Contains Pfam match to entry PF01 [...] | 0.451 |
ML0901 | metB | gene:17574727 | gene:17576256 | Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O69565 (EMBL:AL022602) (304 aa); Fasta score E(): 0, 99.7% identity in 304 aa overlap(EMBL:AL022602). Also highly similar to Mycobacterium tuberculosis hypothetical protein TR:O53506 (EMBL:AL021957) (301 aa); Fasta score E(): 0, 80.9% identity in 299 aa overlap(EMBL:AL021957). | Cystathionine [gamma]-synthase; Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia (By similarity). | 0.612 |
ML0901 | metE | gene:17574727 | gene:17574787 | Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O69565 (EMBL:AL022602) (304 aa); Fasta score E(): 0, 99.7% identity in 304 aa overlap(EMBL:AL022602). Also highly similar to Mycobacterium tuberculosis hypothetical protein TR:O53506 (EMBL:AL021957) (301 aa); Fasta score E(): 0, 80.9% identity in 299 aa overlap(EMBL:AL021957). | 5-methyltetrahydropteroyltriglutamate- homocysteinmethyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation.; Belongs to the vitamin-B12 independent methionine synthase family. | 0.684 |
ML0901 | metH | gene:17574727 | gene:17575141 | Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O69565 (EMBL:AL022602) (304 aa); Fasta score E(): 0, 99.7% identity in 304 aa overlap(EMBL:AL022602). Also highly similar to Mycobacterium tuberculosis hypothetical protein TR:O53506 (EMBL:AL021957) (301 aa); Fasta score E(): 0, 80.9% identity in 299 aa overlap(EMBL:AL021957). | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.964 |
ML0901 | metK | gene:17574727 | gene:17574365 | Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O69565 (EMBL:AL022602) (304 aa); Fasta score E(): 0, 99.7% identity in 304 aa overlap(EMBL:AL022602). Also highly similar to Mycobacterium tuberculosis hypothetical protein TR:O53506 (EMBL:AL021957) (301 aa); Fasta score E(): 0, 80.9% identity in 299 aa overlap(EMBL:AL021957). | Putative S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.636 |
ML0901 | metZ | gene:17574727 | gene:17574094 | Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O69565 (EMBL:AL022602) (304 aa); Fasta score E(): 0, 99.7% identity in 304 aa overlap(EMBL:AL022602). Also highly similar to Mycobacterium tuberculosis hypothetical protein TR:O53506 (EMBL:AL021957) (301 aa); Fasta score E(): 0, 80.9% identity in 299 aa overlap(EMBL:AL021957). | Putative o-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.612 |
cysM2 | glyA | gene:17576258 | gene:17575805 | Similar to Prokaryotic and Eukaryotic cystathionine beta-synthases including: Mycobacterium tuberculosis Rv1077 TR:O53425 (EMBL:AL021897) (464 aa) fasta scores: E(): 0, 90.1% id in 464 aa and Homo sapiens SW:CBS_HUMAN (550 aa) fasta scores: E(): 0, 39.5% id in 479 aa. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme; Similar to ML0839. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.936 |
cysM2 | hom | gene:17576258 | gene:17574956 | Similar to Prokaryotic and Eukaryotic cystathionine beta-synthases including: Mycobacterium tuberculosis Rv1077 TR:O53425 (EMBL:AL021897) (464 aa) fasta scores: E(): 0, 90.1% id in 464 aa and Homo sapiens SW:CBS_HUMAN (550 aa) fasta scores: E(): 0, 39.5% id in 479 aa. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme; Similar to ML0839. | Homoserine dehydrogenase; Identical to the previously sequenced Mycobacterium leprae homoserine dehydrogenase (EC 1.1.1.3) SW:DHOM_MYCLE (P46806) (441 aa); Fasta score E(): 0, 99.8% identity in 441 aa overlap. Also highly similar to orthologues from Mycobacterium tuberculosis SW:DHOM_MYCTU (Q10601) (441 aa); Fasta score E(): 0, 89.5% identity in 438 aa overlap and Corynebacterium glutamicum SW:DHOM_CORGL (P08499) (445 aa); Fasta score E(): 0, 60.3% identity in 431 aa overlap. Contains Pfam match to entry PF00742 Homoserine_dh, Homoserine dehydrogenase. Contains Pfam match to entry PF01 [...] | 0.821 |
cysM2 | metB | gene:17576258 | gene:17576256 | Similar to Prokaryotic and Eukaryotic cystathionine beta-synthases including: Mycobacterium tuberculosis Rv1077 TR:O53425 (EMBL:AL021897) (464 aa) fasta scores: E(): 0, 90.1% id in 464 aa and Homo sapiens SW:CBS_HUMAN (550 aa) fasta scores: E(): 0, 39.5% id in 479 aa. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme; Similar to ML0839. | Cystathionine [gamma]-synthase; Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia (By similarity). | 0.991 |
cysM2 | metE | gene:17576258 | gene:17574787 | Similar to Prokaryotic and Eukaryotic cystathionine beta-synthases including: Mycobacterium tuberculosis Rv1077 TR:O53425 (EMBL:AL021897) (464 aa) fasta scores: E(): 0, 90.1% id in 464 aa and Homo sapiens SW:CBS_HUMAN (550 aa) fasta scores: E(): 0, 39.5% id in 479 aa. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme; Similar to ML0839. | 5-methyltetrahydropteroyltriglutamate- homocysteinmethyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation.; Belongs to the vitamin-B12 independent methionine synthase family. | 0.924 |
cysM2 | metH | gene:17576258 | gene:17575141 | Similar to Prokaryotic and Eukaryotic cystathionine beta-synthases including: Mycobacterium tuberculosis Rv1077 TR:O53425 (EMBL:AL021897) (464 aa) fasta scores: E(): 0, 90.1% id in 464 aa and Homo sapiens SW:CBS_HUMAN (550 aa) fasta scores: E(): 0, 39.5% id in 479 aa. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme; Similar to ML0839. | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.943 |
cysM2 | metZ | gene:17576258 | gene:17574094 | Similar to Prokaryotic and Eukaryotic cystathionine beta-synthases including: Mycobacterium tuberculosis Rv1077 TR:O53425 (EMBL:AL021897) (464 aa) fasta scores: E(): 0, 90.1% id in 464 aa and Homo sapiens SW:CBS_HUMAN (550 aa) fasta scores: E(): 0, 39.5% id in 479 aa. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme; Similar to ML0839. | Putative o-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.982 |
cysM2 | sahH | gene:17576258 | gene:17574595 | Similar to Prokaryotic and Eukaryotic cystathionine beta-synthases including: Mycobacterium tuberculosis Rv1077 TR:O53425 (EMBL:AL021897) (464 aa) fasta scores: E(): 0, 90.1% id in 464 aa and Homo sapiens SW:CBS_HUMAN (550 aa) fasta scores: E(): 0, 39.5% id in 479 aa. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme; Similar to ML0839. | Putative S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.935 |
gcvT | glyA | gene:17574691 | gene:17575805 | Putative aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.998 |
gcvT | metH | gene:17574691 | gene:17575141 | Putative aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.955 |
glyA | ML0901 | gene:17575805 | gene:17574727 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O69565 (EMBL:AL022602) (304 aa); Fasta score E(): 0, 99.7% identity in 304 aa overlap(EMBL:AL022602). Also highly similar to Mycobacterium tuberculosis hypothetical protein TR:O53506 (EMBL:AL021957) (301 aa); Fasta score E(): 0, 80.9% identity in 299 aa overlap(EMBL:AL021957). | 0.408 |
glyA | cysM2 | gene:17575805 | gene:17576258 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Similar to Prokaryotic and Eukaryotic cystathionine beta-synthases including: Mycobacterium tuberculosis Rv1077 TR:O53425 (EMBL:AL021897) (464 aa) fasta scores: E(): 0, 90.1% id in 464 aa and Homo sapiens SW:CBS_HUMAN (550 aa) fasta scores: E(): 0, 39.5% id in 479 aa. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme; Similar to ML0839. | 0.936 |
glyA | gcvT | gene:17575805 | gene:17574691 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.998 |
glyA | metH | gene:17575805 | gene:17575141 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). | 0.946 |