STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tyrStyrosyl-tRNA synthase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (426 aa)    
Predicted Functional Partners:
pheT
phenylalanyl-tRNA synthase [beta] subunit; Highly similar to many phenylalanyl-tRNA synthetase beta chains including: Escherichia coli SW:SYFB_ECOLI (P07395) (795 aa); Fasta score E(): 0, 31.0% identity in 851 aa overlap and Mycobacterium tuberculosis RV1649 SW:SYFB_MYCTU (P94985) (831 aa); Fasta score E(): 0, 79.6% identity in 834 aa overlap.
  
  
 0.918
leuS
leucyl-tRNA synthase; Similar to M. tuberculosis leuS, leucyl-tRNA synthetase, SW:SYL_MYCTU (P71698) (969 aa); Fasta score E(): 0, 83.6% identity in 972 aa overlap and to Bacillus subtilis leuS, leucyl-tRNA synthetase, SW:SYL_BACSU (P36430) (804 aa); Fasta score E(): 0, 45.7% identity in 941 aa overlap. Previously sequenced as SW:SYL_MYCLE (Q50192) (972 aa); Fasta score E(): 0, 99.9% identity in 972 aa overlap. Contains Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V). Contains PS00178 Aminoacyl-transfer RNA synthetases class-I signature.
  
 
 0.864
ML1351
Similar to several DNA-3-methyladenine glycosylases from both Prokaryotes and Eukaryotes e.g. Bacillus subtilis SW:3MGH_BACSU (P94378) (196 aa); Fasta score E(): 7.7e-13, 38.4% identity in 185 aa overlap and Arabidopsis thaliana SW:3MG_ARATH (Q39147) (254 aa); Fasta score E(): 1.1e-11, 32.0% identity in 194 aa overlap. Also highly similar to Mycobacterium tuberculosis RV1688 putative 3-methyladenine DNA glycosylase SW:3MGH_MYCTU (O33190) (203 aa); Fasta score E(): 0, 78.3% identity in 203 aa overlap. Note codon 12 may offer an alternative translational start site; Belongs to the DNA gl [...]
     
 0.858
aspS
aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
  
 
 0.843
thrS
threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
  
 
 0.833
metS
Putative methionyl-tRNA synthase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
  
 
 0.805
ileS
isoleucyl-tRNA synthase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
  
  
 0.803
argS
arginyl-tRNA synthase; Identical to the previously sequenced Mycobacterium leprae arginyl-tRNA synthetase (EC 6.1.1.19) (arginine--tRNA ligase) SW:SYR_MYCLE (P45840) (550 aa); Fasta score E(): 0, 99.6% identity in 550 aa overlap. Also highly similar to many other arginyl-tRNA synthetases including: Mycobacterium tuberculosis SW:SYR_MYCTU (Q10609) (550 aa); Fasta score E(): 0, 84.9% identity in 550 aa overlap and Brevibacterium lactofermentum SW:SYR_BRELA (P41253) (550 aa); Fasta score E(): 0, 63.8% identity in 550 aa overlap. Contains Pfam match to entry PF00750 tRNA-synt_1d, tRNA synt [...]
  
  
 0.793
valS
valyl-tRNA synthase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
  
  
 0.773
ML2647
Putative peptide methionine sulfoxide; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
    
 0.758
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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