STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML1359Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (311 aa)    
Predicted Functional Partners:
tlyA
Cytotoxin/hemolysin; Highly similar to several proposed hemolysins including: Mycobacterium ulcerans TlyA TR:CAB83047 (EMBL:AJ271681) (281 aa); Fasta score E(): 0, 81.0% identity in 268 aa overlap, Treponema hyodysenteriae hemolysin A SW:HLYA_TREHY (Q06803) (240 aa); Fasta score E(): 2.3e-23, 34.9% identity in 238 aa overlap and Mycobacterium tuberculosis TR:Q50760 (EMBL:X98295) (268 aa); Fasta score E(): 0, 78.4% identity in 268 aa overlap. Contains possible membrane spanning hydrophobic domains.
  
  
 0.991
recN
Recombination and DNA repair; May be involved in recombinational repair of damaged DNA.
  
  
 0.968
ML1463
Possible NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.944
ML1357
Conserved hypothetical protein; Highly similar to Mycobacterium tuberculosis RV1693 TR:O33195 (EMBL:Z98268) (58 aa); Fasta score E(): 9.7e-13, 73.8% identity in 61 aa overlap.
     
 0.938
ML1454
Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
 
 
 0.934
ML1511
Conserved hypothetical protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form; Belongs to the sirtuin family. Class III subfamily.
  
 
 0.911
pntAB
Pyridine transhydrogenase subunit [alpha]2; Similar to Mycobacterium tuberculosis PntAB OR RV0156 TR:P96833 (EMBL:Z92770) fasta scores: E(): 3.5e-30, 83.0% id in 100 aa, and to Rhodospirillum rubrum nicotinamide nucleotide transhydrogenase, subunit alpha 2 PntAB TR:Q59764 (EMBL:U01158) fasta scores: E(): 6.1e-11, 42.7% id in 89 aa. Note this is the equivalent to the very C-terminal hydrophobic domain of the larger E. coli and bovine mitochondrial enzymes. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyrid [...]
     
 0.907
pntAA
Pyridine transhydrogenase subunit [alpha]1; Similar to Mycobacterium tuberculosis PntAA OR RV0155 TR:P96832 (EMBL:Z92770) fasta scores: E(): 0, 87.9% id in 365 aa, Haemophilus influenzae NAD PntA SW:PNTA_HAEIN (P43842) fasta scores: E(): 0, 42.6% id in 364 aa, and to Escherichia coli NAD PntA SW:PNTA_ECOLI (P07001; P76888) fasta scores: E(): 0, 42.1% id in 363 aa. Contains Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyridine nucleotide transhydrogenase.
     
 0.905
pntB
Pyridine transhydrogenase subunit [beta]; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
     
 0.903
ML1361
Conserved membrane protein; Highly similar to Mycobacterium tuberculosis hypothetical protein Rv1697 TR:O33198 (EMBL:Z98268) (393 aa); Fasta score E(): 0, 90.6% identity in 393 aa overlap. Contains possible membrane spanning hydrophobic domain.
       0.681
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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