node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML1357 | ML1359 | gene:17575195 | gene:17575197 | Conserved hypothetical protein; Highly similar to Mycobacterium tuberculosis RV1693 TR:O33195 (EMBL:Z98268) (58 aa); Fasta score E(): 9.7e-13, 73.8% identity in 61 aa overlap. | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.938 |
ML1357 | ML1361 | gene:17575195 | gene:17575199 | Conserved hypothetical protein; Highly similar to Mycobacterium tuberculosis RV1693 TR:O33195 (EMBL:Z98268) (58 aa); Fasta score E(): 9.7e-13, 73.8% identity in 61 aa overlap. | Conserved membrane protein; Highly similar to Mycobacterium tuberculosis hypothetical protein Rv1697 TR:O33198 (EMBL:Z98268) (393 aa); Fasta score E(): 0, 90.6% identity in 393 aa overlap. Contains possible membrane spanning hydrophobic domain. | 0.487 |
ML1357 | recN | gene:17575195 | gene:17575198 | Conserved hypothetical protein; Highly similar to Mycobacterium tuberculosis RV1693 TR:O33195 (EMBL:Z98268) (58 aa); Fasta score E(): 9.7e-13, 73.8% identity in 61 aa overlap. | Recombination and DNA repair; May be involved in recombinational repair of damaged DNA. | 0.915 |
ML1357 | tlyA | gene:17575195 | gene:17575196 | Conserved hypothetical protein; Highly similar to Mycobacterium tuberculosis RV1693 TR:O33195 (EMBL:Z98268) (58 aa); Fasta score E(): 9.7e-13, 73.8% identity in 61 aa overlap. | Cytotoxin/hemolysin; Highly similar to several proposed hemolysins including: Mycobacterium ulcerans TlyA TR:CAB83047 (EMBL:AJ271681) (281 aa); Fasta score E(): 0, 81.0% identity in 268 aa overlap, Treponema hyodysenteriae hemolysin A SW:HLYA_TREHY (Q06803) (240 aa); Fasta score E(): 2.3e-23, 34.9% identity in 238 aa overlap and Mycobacterium tuberculosis TR:Q50760 (EMBL:X98295) (268 aa); Fasta score E(): 0, 78.4% identity in 268 aa overlap. Contains possible membrane spanning hydrophobic domains. | 0.869 |
ML1359 | ML1357 | gene:17575197 | gene:17575195 | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Conserved hypothetical protein; Highly similar to Mycobacterium tuberculosis RV1693 TR:O33195 (EMBL:Z98268) (58 aa); Fasta score E(): 9.7e-13, 73.8% identity in 61 aa overlap. | 0.938 |
ML1359 | ML1361 | gene:17575197 | gene:17575199 | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Conserved membrane protein; Highly similar to Mycobacterium tuberculosis hypothetical protein Rv1697 TR:O33198 (EMBL:Z98268) (393 aa); Fasta score E(): 0, 90.6% identity in 393 aa overlap. Contains possible membrane spanning hydrophobic domain. | 0.681 |
ML1359 | ML1454 | gene:17575197 | gene:17575292 | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.934 |
ML1359 | ML1463 | gene:17575197 | gene:17575301 | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Possible NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.944 |
ML1359 | ML1511 | gene:17575197 | gene:17575352 | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Conserved hypothetical protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form; Belongs to the sirtuin family. Class III subfamily. | 0.911 |
ML1359 | pntAA | gene:17575197 | gene:17576502 | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Pyridine transhydrogenase subunit [alpha]1; Similar to Mycobacterium tuberculosis PntAA OR RV0155 TR:P96832 (EMBL:Z92770) fasta scores: E(): 0, 87.9% id in 365 aa, Haemophilus influenzae NAD PntA SW:PNTA_HAEIN (P43842) fasta scores: E(): 0, 42.6% id in 364 aa, and to Escherichia coli NAD PntA SW:PNTA_ECOLI (P07001; P76888) fasta scores: E(): 0, 42.1% id in 363 aa. Contains Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyridine nucleotide transhydrogenase. | 0.905 |
ML1359 | pntAB | gene:17575197 | gene:17576501 | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Pyridine transhydrogenase subunit [alpha]2; Similar to Mycobacterium tuberculosis PntAB OR RV0156 TR:P96833 (EMBL:Z92770) fasta scores: E(): 3.5e-30, 83.0% id in 100 aa, and to Rhodospirillum rubrum nicotinamide nucleotide transhydrogenase, subunit alpha 2 PntAB TR:Q59764 (EMBL:U01158) fasta scores: E(): 6.1e-11, 42.7% id in 89 aa. Note this is the equivalent to the very C-terminal hydrophobic domain of the larger E. coli and bovine mitochondrial enzymes. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyrid [...] | 0.907 |
ML1359 | pntB | gene:17575197 | gene:17576500 | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Pyridine transhydrogenase subunit [beta]; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.903 |
ML1359 | recN | gene:17575197 | gene:17575198 | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Recombination and DNA repair; May be involved in recombinational repair of damaged DNA. | 0.968 |
ML1359 | tlyA | gene:17575197 | gene:17575196 | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Cytotoxin/hemolysin; Highly similar to several proposed hemolysins including: Mycobacterium ulcerans TlyA TR:CAB83047 (EMBL:AJ271681) (281 aa); Fasta score E(): 0, 81.0% identity in 268 aa overlap, Treponema hyodysenteriae hemolysin A SW:HLYA_TREHY (Q06803) (240 aa); Fasta score E(): 2.3e-23, 34.9% identity in 238 aa overlap and Mycobacterium tuberculosis TR:Q50760 (EMBL:X98295) (268 aa); Fasta score E(): 0, 78.4% identity in 268 aa overlap. Contains possible membrane spanning hydrophobic domains. | 0.991 |
ML1361 | ML1357 | gene:17575199 | gene:17575195 | Conserved membrane protein; Highly similar to Mycobacterium tuberculosis hypothetical protein Rv1697 TR:O33198 (EMBL:Z98268) (393 aa); Fasta score E(): 0, 90.6% identity in 393 aa overlap. Contains possible membrane spanning hydrophobic domain. | Conserved hypothetical protein; Highly similar to Mycobacterium tuberculosis RV1693 TR:O33195 (EMBL:Z98268) (58 aa); Fasta score E(): 9.7e-13, 73.8% identity in 61 aa overlap. | 0.487 |
ML1361 | ML1359 | gene:17575199 | gene:17575197 | Conserved membrane protein; Highly similar to Mycobacterium tuberculosis hypothetical protein Rv1697 TR:O33198 (EMBL:Z98268) (393 aa); Fasta score E(): 0, 90.6% identity in 393 aa overlap. Contains possible membrane spanning hydrophobic domain. | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.681 |
ML1361 | recN | gene:17575199 | gene:17575198 | Conserved membrane protein; Highly similar to Mycobacterium tuberculosis hypothetical protein Rv1697 TR:O33198 (EMBL:Z98268) (393 aa); Fasta score E(): 0, 90.6% identity in 393 aa overlap. Contains possible membrane spanning hydrophobic domain. | Recombination and DNA repair; May be involved in recombinational repair of damaged DNA. | 0.528 |
ML1361 | tlyA | gene:17575199 | gene:17575196 | Conserved membrane protein; Highly similar to Mycobacterium tuberculosis hypothetical protein Rv1697 TR:O33198 (EMBL:Z98268) (393 aa); Fasta score E(): 0, 90.6% identity in 393 aa overlap. Contains possible membrane spanning hydrophobic domain. | Cytotoxin/hemolysin; Highly similar to several proposed hemolysins including: Mycobacterium ulcerans TlyA TR:CAB83047 (EMBL:AJ271681) (281 aa); Fasta score E(): 0, 81.0% identity in 268 aa overlap, Treponema hyodysenteriae hemolysin A SW:HLYA_TREHY (Q06803) (240 aa); Fasta score E(): 2.3e-23, 34.9% identity in 238 aa overlap and Mycobacterium tuberculosis TR:Q50760 (EMBL:X98295) (268 aa); Fasta score E(): 0, 78.4% identity in 268 aa overlap. Contains possible membrane spanning hydrophobic domains. | 0.681 |
ML1454 | ML1359 | gene:17575292 | gene:17575197 | Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.934 |
ML1454 | ML1463 | gene:17575292 | gene:17575301 | Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Possible NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.994 |