STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML1370Possible pseudouridine synthase; Highly similar to several pseudouridylate synthases involved in the modification of ribosomal RNA e.g. Bacillus subtilis ribosomal large subunit pseudouridine synthase B SW:RLUB_BACSU (P35159) (229 aa); Fasta score E(): 3.6e-30, 42.8% identity in 229 aa overlap. Also highly similar to Mycobacterium tuberculosis RV1711 SW:YH11_MYCTU (O33210) (254 aa); Fasta score E(): 0, 80.2% identity in 257 aa overlap. Contains Pfam match to entry PF01479 S4, S4 domain. Contains Pfam match to entry PF00849 PseudoU_synth_2, RNA pseudouridylate synthase. Contains PS01149 [...] (257 aa)    
Predicted Functional Partners:
cmk
Cytidylate kinase; Highly similar to several cytidylate kinases (EC 2.7.4.14) including: Bacillus subtilis SW:KCY_BACSU (P38493) (224 aa); Fasta score E(): 1.9e-28, 42.7% identity in 218 aa overlap and Mycobacterium tuberculosis RV1712TR:O33211 (EMBL:Z98268) (230 aa); Fasta score E(): 0, 74.8% identity in 222 aa overlap. Contains Pfam match to entry PF02224 Cytidylate_kin, Cytidylate kinase. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
 
  
 0.996
ML1372
Possible GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
 
  
 0.977
ML1369
Conserved hypothetical protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
  
  
 0.962
ML1368
Conserved hypothetical protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
  
  
 0.890
ML1367
Possible regulatory protein; Similar to several proteins involved in plasmid/chromosome partioning or regulation of sporulation e.g. Neisseria meningitidis ParA family protein TR:CAB83392 (EMBL:AL162752) (257 aa); Fasta score E(): 0, 42.1% identity in 252 aa overlap and Bacillus subtilis SW:SOJ_BACSU (P37522) (253 aa); Fasta score E(): 0, 46.2% identity in 247 aa overlap, respectively. Also highly similar to Mycobacterium tuberculosis RV1708 TR:O33207 (EMBL:Z98268) (318 aa); Fasta score E(): 0, 89.5% identity in 286 aa overlap. Contains Pfam match to entry PF00991 ParA, ParA family ATP [...]
       0.783
ML0468
Putative membrane protein; Similar to bacterial hypothetical proteins e.g. Aeropyrum pernix APE0183, hypothetical protein, TR:Q9YFR6 (EMBL:AP000058) (270 aa); Fasta score E(): 7.2e-07, 26.2% identity in 256 aa overlap. Contains hydrophobic, possible membrane-spanning regions.
       0.493
truB
tRNA pseudouridine 55 synthase; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
 
   
 0.461
frr
Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.
 
  
 0.408
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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