STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cmkCytidylate kinase; Highly similar to several cytidylate kinases (EC 2.7.4.14) including: Bacillus subtilis SW:KCY_BACSU (P38493) (224 aa); Fasta score E(): 1.9e-28, 42.7% identity in 218 aa overlap and Mycobacterium tuberculosis RV1712TR:O33211 (EMBL:Z98268) (230 aa); Fasta score E(): 0, 74.8% identity in 222 aa overlap. Contains Pfam match to entry PF02224 Cytidylate_kin, Cytidylate kinase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). (223 aa)    
Predicted Functional Partners:
ML1372
Possible GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
  
 0.999
ML1370
Possible pseudouridine synthase; Highly similar to several pseudouridylate synthases involved in the modification of ribosomal RNA e.g. Bacillus subtilis ribosomal large subunit pseudouridine synthase B SW:RLUB_BACSU (P35159) (229 aa); Fasta score E(): 3.6e-30, 42.8% identity in 229 aa overlap. Also highly similar to Mycobacterium tuberculosis RV1711 SW:YH11_MYCTU (O33210) (254 aa); Fasta score E(): 0, 80.2% identity in 257 aa overlap. Contains Pfam match to entry PF01479 S4, S4 domain. Contains Pfam match to entry PF00849 PseudoU_synth_2, RNA pseudouridylate synthase. Contains PS01149 [...]
 
  
 0.996
ML1369
Conserved hypothetical protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
 
  
 0.967
ML1368
Conserved hypothetical protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
 
  
 0.929
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
  
 
 0.922
nrdF
Ribonucleotide reductase small subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
    
 0.919
aroA
Putative 3-phosphoshikimate 1-carboxyvinyl transferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
  
 0.917
nrdE
Ribonucleoside diphosphate reductase [alpha] chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
  
 
 0.913
rpsA
30S ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity).
 
  
 0.912
panC
Putative pantoate-[beta]-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
      0.903
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.