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polA protein (Mycobacterium leprae) - STRING interaction network
"polA" - DNA polymerase I in Mycobacterium leprae
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3’-5’ and 5’-3’ exonuclease activity (911 aa)    
Predicted Functional Partners:
recA
Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) (711 aa)
 
 
  0.992
dnaN
Beta sliding clamp; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3’-5’ exonuclease proofreading activity. The beta chain is required for initiation of replication as [...] (399 aa)
 
  0.990
dnaZX
DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3’ to 5’ exonuclease activity (611 aa)
   
 
  0.961
ML0202
Uncharacterized protein; Catalyzes the DNA-template-directed extension of the 3’-end of a DNA strand; the delta’ subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA (405 aa)
 
  0.957
dnaE
DNA polymerase III subunit alpha; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3’ to 5’ exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily (1177 aa)
   
  0.949
dcd
dCTP deaminase; Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; Belongs to the dCTP deaminase family (190 aa)
         
  0.947
pykA
Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Belongs to the pyruvate kinase family (472 aa)
   
 
  0.930
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (136 aa)
   
 
    0.927
ML0603
annotation not available (371 aa)
     
 
  0.904
dgt
Deoxyguanosinetriphosphate triphosphohydrolase-like protein; dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate (429 aa)
         
  0.903
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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