node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
lexA | polA | gene:17574829 | gene:17575220 | LexA, SOS repressor protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | 0.522 |
lexA | recA | gene:17574829 | gene:17574813 | LexA, SOS repressor protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity). | 0.993 |
lexA | recN | gene:17574829 | gene:17575198 | LexA, SOS repressor protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Recombination and DNA repair; May be involved in recombinational repair of damaged DNA. | 0.675 |
lexA | ruvA | gene:17574829 | gene:17574303 | LexA, SOS repressor protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Holliday junction DNA helicase component; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.632 |
lexA | uvrA | gene:17574829 | gene:17575231 | LexA, SOS repressor protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.677 |
lexA | uvrB | gene:17574829 | gene:17575226 | LexA, SOS repressor protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.607 |
lexA | uvrC | gene:17574829 | gene:17574383 | LexA, SOS repressor protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Putative excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.670 |
lexA | uvrD | gene:17574829 | gene:17573968 | LexA, SOS repressor protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Putative ATP-dependent DNA helicase; DNA-dependent ATPase, acting on dsDNA with a 3'-ssDNA tail, unwinding with 3'-to 5'-polarity. Also highly efficient on nicked DNA. Involved in the post-incision events of nucleotide excision repair (By similarity); Belongs to the helicase family. UvrD subfamily. | 0.628 |
mutY | polA | gene:17575772 | gene:17575220 | Similar to M. tuberculosis probable DNA glycosylase Rv3589 TR:O53574 (EMBL:AL022075) (304 aa); Fasta score E(): 0, 74.9% identity in 303 aa overlap, and to many others e.g. Escherichia coli A/G-specific adenine glycosylase mutY SW:MUTY_ECOLI (P17802) (350 aa); Fasta score E(): 1.8e-21, 33.2% identity in 244 aa overlap. Contains Pfam match to entry PF00730 Endonuclease_3, Endonuclease III; Similar to and ML2301. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | 0.498 |
mutY | recA | gene:17575772 | gene:17574813 | Similar to M. tuberculosis probable DNA glycosylase Rv3589 TR:O53574 (EMBL:AL022075) (304 aa); Fasta score E(): 0, 74.9% identity in 303 aa overlap, and to many others e.g. Escherichia coli A/G-specific adenine glycosylase mutY SW:MUTY_ECOLI (P17802) (350 aa); Fasta score E(): 1.8e-21, 33.2% identity in 244 aa overlap. Contains Pfam match to entry PF00730 Endonuclease_3, Endonuclease III; Similar to and ML2301. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity). | 0.430 |
mutY | recN | gene:17575772 | gene:17575198 | Similar to M. tuberculosis probable DNA glycosylase Rv3589 TR:O53574 (EMBL:AL022075) (304 aa); Fasta score E(): 0, 74.9% identity in 303 aa overlap, and to many others e.g. Escherichia coli A/G-specific adenine glycosylase mutY SW:MUTY_ECOLI (P17802) (350 aa); Fasta score E(): 1.8e-21, 33.2% identity in 244 aa overlap. Contains Pfam match to entry PF00730 Endonuclease_3, Endonuclease III; Similar to and ML2301. | Recombination and DNA repair; May be involved in recombinational repair of damaged DNA. | 0.483 |
mutY | uvrB | gene:17575772 | gene:17575226 | Similar to M. tuberculosis probable DNA glycosylase Rv3589 TR:O53574 (EMBL:AL022075) (304 aa); Fasta score E(): 0, 74.9% identity in 303 aa overlap, and to many others e.g. Escherichia coli A/G-specific adenine glycosylase mutY SW:MUTY_ECOLI (P17802) (350 aa); Fasta score E(): 1.8e-21, 33.2% identity in 244 aa overlap. Contains Pfam match to entry PF00730 Endonuclease_3, Endonuclease III; Similar to and ML2301. | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.798 |
mutY | uvrD | gene:17575772 | gene:17573968 | Similar to M. tuberculosis probable DNA glycosylase Rv3589 TR:O53574 (EMBL:AL022075) (304 aa); Fasta score E(): 0, 74.9% identity in 303 aa overlap, and to many others e.g. Escherichia coli A/G-specific adenine glycosylase mutY SW:MUTY_ECOLI (P17802) (350 aa); Fasta score E(): 1.8e-21, 33.2% identity in 244 aa overlap. Contains Pfam match to entry PF00730 Endonuclease_3, Endonuclease III; Similar to and ML2301. | Putative ATP-dependent DNA helicase; DNA-dependent ATPase, acting on dsDNA with a 3'-ssDNA tail, unwinding with 3'-to 5'-polarity. Also highly efficient on nicked DNA. Involved in the post-incision events of nucleotide excision repair (By similarity); Belongs to the helicase family. UvrD subfamily. | 0.798 |
polA | lexA | gene:17575220 | gene:17574829 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | LexA, SOS repressor protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.522 |
polA | mutY | gene:17575220 | gene:17575772 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | Similar to M. tuberculosis probable DNA glycosylase Rv3589 TR:O53574 (EMBL:AL022075) (304 aa); Fasta score E(): 0, 74.9% identity in 303 aa overlap, and to many others e.g. Escherichia coli A/G-specific adenine glycosylase mutY SW:MUTY_ECOLI (P17802) (350 aa); Fasta score E(): 1.8e-21, 33.2% identity in 244 aa overlap. Contains Pfam match to entry PF00730 Endonuclease_3, Endonuclease III; Similar to and ML2301. | 0.498 |
polA | recA | gene:17575220 | gene:17574813 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity). | 0.999 |
polA | recN | gene:17575220 | gene:17575198 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | Recombination and DNA repair; May be involved in recombinational repair of damaged DNA. | 0.537 |
polA | ruvA | gene:17575220 | gene:17574303 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | Holliday junction DNA helicase component; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. | 0.624 |
polA | uvrA | gene:17575220 | gene:17575231 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.635 |
polA | uvrB | gene:17575220 | gene:17575226 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.689 |