node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML0978 | argB | gene:17574804 | gene:17575247 | Putative acetyltransferase; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O05559 (EMBL:Z94723) (180 aa); Fasta score E(): 0, 100.0% identity in 180 aa overlap. Also similar to several acetyltransferases including: Escherichia coli amino-acid acetyltransferase (EC 2.3.1.1) SW:ARGA_ECOLI (P08205) (443 aa); Fasta score E(): 0.0013, 26.8% identity in 123 aa overlap and Streptomyces coelicolor putative acetyltransferase TR:Q9X8N2 (EMBL:AL049628) (169 aa); Fasta score E(): 0, 59.8% identity in 164 aa overlap. Highly similar to Mycobacterium tuberculosis h [...] | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | 0.931 |
ML0978 | argD | gene:17574804 | gene:17575248 | Putative acetyltransferase; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O05559 (EMBL:Z94723) (180 aa); Fasta score E(): 0, 100.0% identity in 180 aa overlap. Also similar to several acetyltransferases including: Escherichia coli amino-acid acetyltransferase (EC 2.3.1.1) SW:ARGA_ECOLI (P08205) (443 aa); Fasta score E(): 0.0013, 26.8% identity in 123 aa overlap and Streptomyces coelicolor putative acetyltransferase TR:Q9X8N2 (EMBL:AL049628) (169 aa); Fasta score E(): 0, 59.8% identity in 164 aa overlap. Highly similar to Mycobacterium tuberculosis h [...] | Highly similar to many acetylornithine aminotransferases (EC 2.6.1.11) involved in arginine biosynthesis, including: Escherichia coli SW:ARGD_ECOLI (P18335) (405 aa); Fasta score E(): 0, 38.7% identity in 390 aa overlap and Mycobacterium tuberculosis RV1655 SW:ARGD_MYCTU (P94990) (400 aa); Fasta score E(): 0, 82.9% identity in 397 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. | 0.656 |
ML0978 | argF | gene:17574804 | gene:17575249 | Putative acetyltransferase; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O05559 (EMBL:Z94723) (180 aa); Fasta score E(): 0, 100.0% identity in 180 aa overlap. Also similar to several acetyltransferases including: Escherichia coli amino-acid acetyltransferase (EC 2.3.1.1) SW:ARGA_ECOLI (P08205) (443 aa); Fasta score E(): 0.0013, 26.8% identity in 123 aa overlap and Streptomyces coelicolor putative acetyltransferase TR:Q9X8N2 (EMBL:AL049628) (169 aa); Fasta score E(): 0, 59.8% identity in 164 aa overlap. Highly similar to Mycobacterium tuberculosis h [...] | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.633 |
ML0978 | argG | gene:17574804 | gene:17575251 | Putative acetyltransferase; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O05559 (EMBL:Z94723) (180 aa); Fasta score E(): 0, 100.0% identity in 180 aa overlap. Also similar to several acetyltransferases including: Escherichia coli amino-acid acetyltransferase (EC 2.3.1.1) SW:ARGA_ECOLI (P08205) (443 aa); Fasta score E(): 0.0013, 26.8% identity in 123 aa overlap and Streptomyces coelicolor putative acetyltransferase TR:Q9X8N2 (EMBL:AL049628) (169 aa); Fasta score E(): 0, 59.8% identity in 164 aa overlap. Highly similar to Mycobacterium tuberculosis h [...] | Arginosuccinate synthase; Highly similar to many argininosuccinate synthases (EC 6.3.4.5) involved in arginine biosynthesis, including: Streptomyces clavuligerus SW:ASSY_STRCL (P50986) (397 aa); Fasta score E(): 0, 67.0% identity in 397 aa overlap and Mycobacterium tuberculosis SW:ASSY_MYCTU (P94993) (398 aa); Fasta score E(): 0, 91.0% identity in 398 aa overlap. Contains Pfam match to entry PF00764 Arginosuc_synth, Arginosuccinate synthase. Contains PS00564 Argininosuccinate synthase signature 1. Contains PS00565 Argininosuccinate synthase signature 2. | 0.479 |
ML0978 | argJ | gene:17574804 | gene:17575246 | Putative acetyltransferase; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O05559 (EMBL:Z94723) (180 aa); Fasta score E(): 0, 100.0% identity in 180 aa overlap. Also similar to several acetyltransferases including: Escherichia coli amino-acid acetyltransferase (EC 2.3.1.1) SW:ARGA_ECOLI (P08205) (443 aa); Fasta score E(): 0.0013, 26.8% identity in 123 aa overlap and Streptomyces coelicolor putative acetyltransferase TR:Q9X8N2 (EMBL:AL049628) (169 aa); Fasta score E(): 0, 59.8% identity in 164 aa overlap. Highly similar to Mycobacterium tuberculosis h [...] | Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. | 0.958 |
ML0978 | argR | gene:17574804 | gene:17575250 | Putative acetyltransferase; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O05559 (EMBL:Z94723) (180 aa); Fasta score E(): 0, 100.0% identity in 180 aa overlap. Also similar to several acetyltransferases including: Escherichia coli amino-acid acetyltransferase (EC 2.3.1.1) SW:ARGA_ECOLI (P08205) (443 aa); Fasta score E(): 0.0013, 26.8% identity in 123 aa overlap and Streptomyces coelicolor putative acetyltransferase TR:Q9X8N2 (EMBL:AL049628) (169 aa); Fasta score E(): 0, 59.8% identity in 164 aa overlap. Highly similar to Mycobacterium tuberculosis h [...] | Arginine repressor; Regulates arginine biosynthesis genes. | 0.400 |
argB | ML0978 | gene:17575247 | gene:17574804 | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | Putative acetyltransferase; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O05559 (EMBL:Z94723) (180 aa); Fasta score E(): 0, 100.0% identity in 180 aa overlap. Also similar to several acetyltransferases including: Escherichia coli amino-acid acetyltransferase (EC 2.3.1.1) SW:ARGA_ECOLI (P08205) (443 aa); Fasta score E(): 0.0013, 26.8% identity in 123 aa overlap and Streptomyces coelicolor putative acetyltransferase TR:Q9X8N2 (EMBL:AL049628) (169 aa); Fasta score E(): 0, 59.8% identity in 164 aa overlap. Highly similar to Mycobacterium tuberculosis h [...] | 0.931 |
argB | argC | gene:17575247 | gene:17575245 | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | N-acetyl-[gamma]-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. | 0.999 |
argB | argD | gene:17575247 | gene:17575248 | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | Highly similar to many acetylornithine aminotransferases (EC 2.6.1.11) involved in arginine biosynthesis, including: Escherichia coli SW:ARGD_ECOLI (P18335) (405 aa); Fasta score E(): 0, 38.7% identity in 390 aa overlap and Mycobacterium tuberculosis RV1655 SW:ARGD_MYCTU (P94990) (400 aa); Fasta score E(): 0, 82.9% identity in 397 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. | 0.995 |
argB | argF | gene:17575247 | gene:17575249 | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.992 |
argB | argG | gene:17575247 | gene:17575251 | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | Arginosuccinate synthase; Highly similar to many argininosuccinate synthases (EC 6.3.4.5) involved in arginine biosynthesis, including: Streptomyces clavuligerus SW:ASSY_STRCL (P50986) (397 aa); Fasta score E(): 0, 67.0% identity in 397 aa overlap and Mycobacterium tuberculosis SW:ASSY_MYCTU (P94993) (398 aa); Fasta score E(): 0, 91.0% identity in 398 aa overlap. Contains Pfam match to entry PF00764 Arginosuc_synth, Arginosuccinate synthase. Contains PS00564 Argininosuccinate synthase signature 1. Contains PS00565 Argininosuccinate synthase signature 2. | 0.970 |
argB | argH | gene:17575247 | gene:17575252 | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | Arginosuccinate lyase; Highly similar to many argininosuccinate lyases (EC 4.3.2.1) involved in arginine biosynthesis, including: Escherichia coli SW:ARLY_ECOLI (P11447) (172 aa); BlastP Expect 9.3 and Mycobacterium tuberculosis SW:ARLY_MYCTU (P94994) (470 aa); Fasta score E(): 0, 88.1% identity in 470 aa overlap. Contains Pfam match to entry PF00206 lyase_1, Lyase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00163 Fumarate lyases signature. | 0.969 |
argB | argJ | gene:17575247 | gene:17575246 | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. | 0.999 |
argB | argR | gene:17575247 | gene:17575250 | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | Arginine repressor; Regulates arginine biosynthesis genes. | 0.994 |
argB | proA | gene:17575247 | gene:17575296 | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | [gamma]-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. | 0.869 |
argB | proB | gene:17575247 | gene:17575302 | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. | 0.881 |
argC | argB | gene:17575245 | gene:17575247 | N-acetyl-[gamma]-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. | 0.999 |
argC | argD | gene:17575245 | gene:17575248 | N-acetyl-[gamma]-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. | Highly similar to many acetylornithine aminotransferases (EC 2.6.1.11) involved in arginine biosynthesis, including: Escherichia coli SW:ARGD_ECOLI (P18335) (405 aa); Fasta score E(): 0, 38.7% identity in 390 aa overlap and Mycobacterium tuberculosis RV1655 SW:ARGD_MYCTU (P94990) (400 aa); Fasta score E(): 0, 82.9% identity in 397 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. | 0.999 |
argC | argF | gene:17575245 | gene:17575249 | N-acetyl-[gamma]-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.984 |
argC | argG | gene:17575245 | gene:17575251 | N-acetyl-[gamma]-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. | Arginosuccinate synthase; Highly similar to many argininosuccinate synthases (EC 6.3.4.5) involved in arginine biosynthesis, including: Streptomyces clavuligerus SW:ASSY_STRCL (P50986) (397 aa); Fasta score E(): 0, 67.0% identity in 397 aa overlap and Mycobacterium tuberculosis SW:ASSY_MYCTU (P94993) (398 aa); Fasta score E(): 0, 91.0% identity in 398 aa overlap. Contains Pfam match to entry PF00764 Arginosuc_synth, Arginosuccinate synthase. Contains PS00564 Argininosuccinate synthase signature 1. Contains PS00565 Argininosuccinate synthase signature 2. | 0.965 |