STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML1468Possible ribonuclease; Highly similar in parts to many ribonucleases e.g. Escherichia coli ribonuclease E (EC 3.1.4.-) SW:RNE_ECOLI (P21513) (1061 aa); Fasta score E(): 1.6e-22, 36.4% identity in 429 aa overlap and Mycobacterium tuberculosis RV2444C TR:P71905 (EMBL:Z81451) (953 aa); Fasta score E(): 0, 74.2% identity in 966 aa overlap. Contains Pfam match to entry PF00575 S1, S1 RNA binding domain. (924 aa)    
Predicted Functional Partners:
gpsI
Putative polyribonucleotide phosphorylase / guanosine pentaphosphate synthetase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
  
 
 0.942
rhlE
Similar to Mycobacterium tuberculosis putative ATP-dependent RNA helicase Rv3211 or MTCY07D11.15c (407 aa) TR:O05855 (EMBL:Z95120) fasta scores: E(): 0, 74.8% id in 531 aa, and to Klebsiella pneumoniae ATP-dependent RNA helicase deaD SW:DEAD_KLEPN (P33906) fasta scores: E(): 0, 43.2% id in 380 aa. Contains Pfam match to entry PF00271 helicase_C, Helicases conserved C-terminal domain. Contains Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00039 DEAD-box subfamily ATP-dependent helicases signature.
   
 
 0.867
ML1512
Conserved hypothetical protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
     
 0.798
rplU
50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
  
    0.707
rpmA
Highly similar to many 50s ribosomal proteins (L27) including: Escherichia coli SW:RL27_ECOLI (P02427) (84 aa); Fasta score E(): 5.8e-16, 63.9% identity in 83 aa overlap and Mycobacterium tuberculosis RV2441C SW:RL27_MYCTU (Z8145) (86 aa); Fasta score E(): 3.3e-28, 93.8% identity in 81 aa overlap. Contains Pfam match to entry PF01016 Ribosomal_L27, Ribosomal L27 protein. Contains PS00831 Ribosomal protein L27 signature; Belongs to the bacterial ribosomal protein bL27 family.
     
 0.692
proB
Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
  
    0.633
eno
Putative enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
    
 
 0.569
ML0563
Conserved hypothetical protein; Displays ATPase and GTPase activities.
   
 
 0.546
rphA
Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
  
   
 0.505
ML2709
Conserved hypothetical protein; Similar to Mycobacterium paratuberculosis hypothetical 20.1 kda protein TR:AAF33691 (EMBL:AF222789) fasta scores: E(): 0, 76.0% in 183 aa, and to Mycobacterium tuberculosis hypothetical 20.6 kda protein TR:O53598 (EMBL:AL021426) fasta scores: E(): 0, 73.1% in 193 aa. Contains Pfam match to entry PF01424 R3H, R3H domain.
   
   0.499
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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