STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Experiments
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[Homology]
Score
ML1591Possible uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (279 aa)    
Predicted Functional Partners:
frr
Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.
 
  
 0.977
pyrF
Similar to M. tuberculosis pyrF, Rv1385, orotidine 5'-phosphate decarboxylase, SW:DCOP_MYCTU (P77898) (274 aa); Fasta score E(): 0, 77.3% identity in 282 aa overlap. Similar to many e.g. Mycobacterium smegmatis pyrF, orotidine 5'-phosphate decarboxylase, SW:DCOP_MYCSM (O08323) (276 aa); Fasta score E(): 0, 72.5% identity in 280 aa overlap. Contains Pfam match to entry PF00215 OMPdecase, Orotidine 5'-phosphate decarboxylases. Contains PS00156 Orotidine 5'-phosphate decarboxylase active site; Belongs to the OMP decarboxylase family. Type 2 subfamily.
   
 
 0.930
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 
 0.924
atpH
Bi-domained ATP synthase B, [Delta] chain protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity).
  
  
 0.923
tsf
Elongation factor EF-Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity); Belongs to the EF-Ts family.
 
  
 0.884
rpsB
Highly similar to many 30s ribosomal proteins (S2) including: Bacillus subtilis SW:RS2_BACSU (P21464) (245 aa); Fasta score E(): 0, 57.6% identity in 250 aa overlap and Mycobacterium tuberculosis RV2890C SW:RS2_MYCTU (Q10796) (287 aa); Fasta score E(): 0, 91.5% identity in 270 aa overlap. Contains Pfam match to entry PF00318 Ribosomal_S2, Ribosomal protein S2. Contains PS00962 Ribosomal protein S2 signature 1; Belongs to the universal ribosomal protein uS2 family.
 
  
 0.870
ML1589
Possible phosphatidate cytidylyltransferase; The C-terminus of this protein is highly similar to many proteins involved with phospholipid biosynthesis e.g. Escherichia coli phosphatidate cytidylyltransferase (EC 2.7.7.41) SW:CDSA_ECOLI (P06466) (249 aa); Fasta score E(): 6.6e-15, 40.6% identity in 160 aa overlap and Mycobacterium tuberculosis Rv2881c SW:CDSA_MYCTU (Q10807) (306 aa); Fasta score E(): 0, 70.3% identity in 313 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01148 Cytidylyltrans, Phosphatidate cytidylyltransferas [...]
 
  
 0.824
adk
Probable adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
  
  
 0.802
rplS
50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
  
  
 0.787
rpsJ
30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.
   
  
 0.777
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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