node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML1610 | ML1612 | gene:17575451 | gene:17575453 | Conserved hypothetical protein; Similar to several proteins of unknown function from Mycobacterium tuberculosis e.g. SW:YT01_MYCTU (Q10822) (101 aa); Fasta score E(): 0, 99.0% identity in 101 aa overlap. | Similar in parts to many proposed signal peptidases e.g. Bacillus subtilis SW:LEPT_BACSU (P71013) (193 aa); Fasta score E(): 1.1e-07, 31.0% identity in 226 aa overlap and Mycobacterium tuberculosis RV2903C SW:LEP_MYCTU (Q1078) (294 aa); Fasta score E(): 0, 69.8% identity in 301 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF00461 Peptidase_S26, Signal peptidase I. Contains PS00501 Signal peptidases I serine active site. Contains PS00761 Signal peptidases I signature 3. | 0.730 |
ML1610 | rnhB | gene:17575451 | gene:17575452 | Conserved hypothetical protein; Similar to several proteins of unknown function from Mycobacterium tuberculosis e.g. SW:YT01_MYCTU (Q10822) (101 aa); Fasta score E(): 0, 99.0% identity in 101 aa overlap. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.730 |
ML1610 | rplS | gene:17575451 | gene:17575454 | Conserved hypothetical protein; Similar to several proteins of unknown function from Mycobacterium tuberculosis e.g. SW:YT01_MYCTU (Q10822) (101 aa); Fasta score E(): 0, 99.0% identity in 101 aa overlap. | 50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.667 |
ML1612 | ML1610 | gene:17575453 | gene:17575451 | Similar in parts to many proposed signal peptidases e.g. Bacillus subtilis SW:LEPT_BACSU (P71013) (193 aa); Fasta score E(): 1.1e-07, 31.0% identity in 226 aa overlap and Mycobacterium tuberculosis RV2903C SW:LEP_MYCTU (Q1078) (294 aa); Fasta score E(): 0, 69.8% identity in 301 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF00461 Peptidase_S26, Signal peptidase I. Contains PS00501 Signal peptidases I serine active site. Contains PS00761 Signal peptidases I signature 3. | Conserved hypothetical protein; Similar to several proteins of unknown function from Mycobacterium tuberculosis e.g. SW:YT01_MYCTU (Q10822) (101 aa); Fasta score E(): 0, 99.0% identity in 101 aa overlap. | 0.730 |
ML1612 | atpE | gene:17575453 | gene:17574967 | Similar in parts to many proposed signal peptidases e.g. Bacillus subtilis SW:LEPT_BACSU (P71013) (193 aa); Fasta score E(): 1.1e-07, 31.0% identity in 226 aa overlap and Mycobacterium tuberculosis RV2903C SW:LEP_MYCTU (Q1078) (294 aa); Fasta score E(): 0, 69.8% identity in 301 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF00461 Peptidase_S26, Signal peptidase I. Contains PS00501 Signal peptidases I serine active site. Contains PS00761 Signal peptidases I signature 3. | Probable ATP synthase C chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | 0.688 |
ML1612 | lepA | gene:17575453 | gene:17574432 | Similar in parts to many proposed signal peptidases e.g. Bacillus subtilis SW:LEPT_BACSU (P71013) (193 aa); Fasta score E(): 1.1e-07, 31.0% identity in 226 aa overlap and Mycobacterium tuberculosis RV2903C SW:LEP_MYCTU (Q1078) (294 aa); Fasta score E(): 0, 69.8% identity in 301 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF00461 Peptidase_S26, Signal peptidase I. Contains PS00501 Signal peptidases I serine active site. Contains PS00761 Signal peptidases I signature 3. | Putative GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic transla [...] | 0.736 |
ML1612 | lspA | gene:17575453 | gene:17575030 | Similar in parts to many proposed signal peptidases e.g. Bacillus subtilis SW:LEPT_BACSU (P71013) (193 aa); Fasta score E(): 1.1e-07, 31.0% identity in 226 aa overlap and Mycobacterium tuberculosis RV2903C SW:LEP_MYCTU (Q1078) (294 aa); Fasta score E(): 0, 69.8% identity in 301 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF00461 Peptidase_S26, Signal peptidase I. Contains PS00501 Signal peptidases I serine active site. Contains PS00761 Signal peptidases I signature 3. | Lipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | 0.644 |
ML1612 | panC | gene:17575453 | gene:17574047 | Similar in parts to many proposed signal peptidases e.g. Bacillus subtilis SW:LEPT_BACSU (P71013) (193 aa); Fasta score E(): 1.1e-07, 31.0% identity in 226 aa overlap and Mycobacterium tuberculosis RV2903C SW:LEP_MYCTU (Q1078) (294 aa); Fasta score E(): 0, 69.8% identity in 301 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF00461 Peptidase_S26, Signal peptidase I. Contains PS00501 Signal peptidases I serine active site. Contains PS00761 Signal peptidases I signature 3. | Putative pantoate-[beta]-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.708 |
ML1612 | rnhB | gene:17575453 | gene:17575452 | Similar in parts to many proposed signal peptidases e.g. Bacillus subtilis SW:LEPT_BACSU (P71013) (193 aa); Fasta score E(): 1.1e-07, 31.0% identity in 226 aa overlap and Mycobacterium tuberculosis RV2903C SW:LEP_MYCTU (Q1078) (294 aa); Fasta score E(): 0, 69.8% identity in 301 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF00461 Peptidase_S26, Signal peptidase I. Contains PS00501 Signal peptidases I serine active site. Contains PS00761 Signal peptidases I signature 3. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.948 |
ML1612 | rplS | gene:17575453 | gene:17575454 | Similar in parts to many proposed signal peptidases e.g. Bacillus subtilis SW:LEPT_BACSU (P71013) (193 aa); Fasta score E(): 1.1e-07, 31.0% identity in 226 aa overlap and Mycobacterium tuberculosis RV2903C SW:LEP_MYCTU (Q1078) (294 aa); Fasta score E(): 0, 69.8% identity in 301 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF00461 Peptidase_S26, Signal peptidase I. Contains PS00501 Signal peptidases I serine active site. Contains PS00761 Signal peptidases I signature 3. | 50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.774 |
ML1612 | secA | gene:17575453 | gene:17574603 | Similar in parts to many proposed signal peptidases e.g. Bacillus subtilis SW:LEPT_BACSU (P71013) (193 aa); Fasta score E(): 1.1e-07, 31.0% identity in 226 aa overlap and Mycobacterium tuberculosis RV2903C SW:LEP_MYCTU (Q1078) (294 aa); Fasta score E(): 0, 69.8% identity in 301 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF00461 Peptidase_S26, Signal peptidase I. Contains PS00501 Signal peptidases I serine active site. Contains PS00761 Signal peptidases I signature 3. | Putative preprotein translocase subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.740 |
ML1612 | secE | gene:17575453 | gene:17575755 | Similar in parts to many proposed signal peptidases e.g. Bacillus subtilis SW:LEPT_BACSU (P71013) (193 aa); Fasta score E(): 1.1e-07, 31.0% identity in 226 aa overlap and Mycobacterium tuberculosis RV2903C SW:LEP_MYCTU (Q1078) (294 aa); Fasta score E(): 0, 69.8% identity in 301 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF00461 Peptidase_S26, Signal peptidase I. Contains PS00501 Signal peptidases I serine active site. Contains PS00761 Signal peptidases I signature 3. | SecE preprotein translocase; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.834 |
ML1612 | secY | gene:17575453 | gene:17575681 | Similar in parts to many proposed signal peptidases e.g. Bacillus subtilis SW:LEPT_BACSU (P71013) (193 aa); Fasta score E(): 1.1e-07, 31.0% identity in 226 aa overlap and Mycobacterium tuberculosis RV2903C SW:LEP_MYCTU (Q1078) (294 aa); Fasta score E(): 0, 69.8% identity in 301 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF00461 Peptidase_S26, Signal peptidase I. Contains PS00501 Signal peptidases I serine active site. Contains PS00761 Signal peptidases I signature 3. | SecY subunit of preprotein translocase; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.708 |
atpE | ML1612 | gene:17574967 | gene:17575453 | Probable ATP synthase C chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | Similar in parts to many proposed signal peptidases e.g. Bacillus subtilis SW:LEPT_BACSU (P71013) (193 aa); Fasta score E(): 1.1e-07, 31.0% identity in 226 aa overlap and Mycobacterium tuberculosis RV2903C SW:LEP_MYCTU (Q1078) (294 aa); Fasta score E(): 0, 69.8% identity in 301 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF00461 Peptidase_S26, Signal peptidase I. Contains PS00501 Signal peptidases I serine active site. Contains PS00761 Signal peptidases I signature 3. | 0.688 |
atpE | secY | gene:17574967 | gene:17575681 | Probable ATP synthase C chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. | SecY subunit of preprotein translocase; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.695 |
lepA | ML1612 | gene:17574432 | gene:17575453 | Putative GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic transla [...] | Similar in parts to many proposed signal peptidases e.g. Bacillus subtilis SW:LEPT_BACSU (P71013) (193 aa); Fasta score E(): 1.1e-07, 31.0% identity in 226 aa overlap and Mycobacterium tuberculosis RV2903C SW:LEP_MYCTU (Q1078) (294 aa); Fasta score E(): 0, 69.8% identity in 301 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF00461 Peptidase_S26, Signal peptidase I. Contains PS00501 Signal peptidases I serine active site. Contains PS00761 Signal peptidases I signature 3. | 0.736 |
lepA | rplS | gene:17574432 | gene:17575454 | Putative GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic transla [...] | 50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.961 |
lspA | ML1612 | gene:17575030 | gene:17575453 | Lipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | Similar in parts to many proposed signal peptidases e.g. Bacillus subtilis SW:LEPT_BACSU (P71013) (193 aa); Fasta score E(): 1.1e-07, 31.0% identity in 226 aa overlap and Mycobacterium tuberculosis RV2903C SW:LEP_MYCTU (Q1078) (294 aa); Fasta score E(): 0, 69.8% identity in 301 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF00461 Peptidase_S26, Signal peptidase I. Contains PS00501 Signal peptidases I serine active site. Contains PS00761 Signal peptidases I signature 3. | 0.644 |
lspA | secA | gene:17575030 | gene:17574603 | Lipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | Putative preprotein translocase subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. | 0.565 |
panC | ML1612 | gene:17574047 | gene:17575453 | Putative pantoate-[beta]-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | Similar in parts to many proposed signal peptidases e.g. Bacillus subtilis SW:LEPT_BACSU (P71013) (193 aa); Fasta score E(): 1.1e-07, 31.0% identity in 226 aa overlap and Mycobacterium tuberculosis RV2903C SW:LEP_MYCTU (Q1078) (294 aa); Fasta score E(): 0, 69.8% identity in 301 aa overlap. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF00461 Peptidase_S26, Signal peptidase I. Contains PS00501 Signal peptidases I serine active site. Contains PS00761 Signal peptidases I signature 3. | 0.708 |