STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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[Homology]
Score
glnEGlutamate-ammonia-ligase adenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduc [...] (1004 aa)    
Predicted Functional Partners:
glnA
Highly similar to many glutamine synthetases (EC 6.3.1.2) including examples from: Mycobacterium tuberculosis SW:GLN1_MYCTU (Q10377) (478 aa); Fasta score E(): 0, 91.8% identity in 478 aa overlap and Salmonella typhimurium SW:GLNA_SALTY (P06201) (468 aa); Fasta score E(): 0, 51.5% identity in 474 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase. Contains PS00182 Glutamine synthetase class-I adenylation site. Contains PS00180 Glutamine synthetase signature 1. Contains PS00181 Glutamine synthetase putative ATP-binding region signature; Similar to ML1631.
 
  
 0.964
glnA2
Glutamine synthase class II; Highly similar to many glutamine synthetases (EC 6.3.1.2) including: Bacillus subtilis SW:GLNA_BACSU (P12425) (443 aa); Fasta score E(): 0, 45.4% identity in 445 aa overlap and Mycobacterium tuberculosis RV2222C SW:GLN2_MYCTU (Q10378) (446 aa); Fasta score E(): 0, 93.3% identity in 448 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase; Similar to ML0925.
  
  
 0.955
ML1632
Possible hydrolase; Highly similar to several including: Streptomyces lividans tripeptidylaminopeptidase precursor TR:Q54410 (EMBL:L27466) (537 aa); Fasta score E(): 0, 30.9% identity in 489 aa overlap and several proteins of undefined function e.g. Mycobacterium tuberculosis RV2223C SW:YM23_MYCTU (Q10508) (520 aa); Fasta score E(): 0, 75.8% identity in 520 aa overlap. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold; Similar to ML1633.
       0.710
gltB
Similar to M. tuberculosis Rv3859c, putative ferredoxin-dependent glutamate synthase, TR:P96218 (EMBL:Al123456) (1527 aa); Fasta score E(): 0, 90.2% identity in 1527 aa overlap and to Synechocystis sp. gltB, ferredoxin-dependent glutamate synthase 1, SW:GLTB_SYNY3 (P55037) (1550 aa); Fasta score E(): 0, 57.2% identity in 1525 aa overlap. Contains Pfam match to entry PF01493 DUF14, Domain of unknown function. Contains Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature.
     
 0.677
ML1633
Possible secreted hydrolase; Highly similar to several including: Streptomyces lividans tripeptidylaminopeptidase precursor TR:Q54410 (EMBL:L27466) (537 aa); Fasta score E(): 4.3e-23, 30.7% identity in 508 aa overlap and several proteins of undefined function e.g. Mycobacterium tuberculosis RV2223C SW:YM23_MYCTU (Q10508) (520 aa); Fasta score E(): 0, 50.1% identity in 511 aa overlap. Note this CDS is also highly similar to the adjoining CDS ML1632. Contains a possible N-terminal signal sequence. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold; Similar to ML1632.
       0.656
ML1040
Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q50004 (EMBL:U15181) (429 aa); Fasta score E(): 0, 100.0% identity in 429 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2681 TR:O07183 (EMBL:Z96072) (438 aa); Fasta score E(): 0, 77.4% identity in 416 aa overlap. The predicted product of this CDS is also weakly similar to several nucleases e.g. Escherichia coli SW:RND_ECOLI (P09155) (375 aa); Fasta score E(): 2.4e-08, 26.7% identity in 371 aa overlap ribonuclease D (EC 3.1.26.3). Cont [...]
  
     0.593
ML1439
Conserved hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family.
  
     0.573
ML0013
Conserved hypothetical protein; Involved in cell division; Belongs to the CrgA family.
      
 0.548
ML2073
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 24.0 kda protein Rv1830 SW:YI30_MYCTU (Q50603) fasta scores: E(): 0, 90.0% in 231 aa, and to Streptomyces coelicolor hypothetical 19.1 kda protein TR:CAB88877 (EMBL:AL353861) fasta scores: E(): 3.7e-30, 64.8% in 145 aa.
  
     0.529
ML1026
Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q4998. Also highly similar to hypothetical proteins from Mycobacterium tuberculosis Rv2699c TR:O07201 (EMBL:Z96072) (100 aa); Fasta score E(): 0, 96.0% identity in 100 aa overlap and Streptomyces coelicolor TR:O54130 (EMBL:AL021530) (98 aa); Fasta score E(): 3.4e-26, 70.4% identity in 98 aa overlap.
  
     0.492
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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