STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rncRNAse III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (238 aa)    
Predicted Functional Partners:
rplS
50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
 
 
 0.973
rpsO
30S ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
   
 
 0.966
rplM
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
   
 
 0.960
rplV
50S ribosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).
   
 
 0.958
rpmA
Highly similar to many 50s ribosomal proteins (L27) including: Escherichia coli SW:RL27_ECOLI (P02427) (84 aa); Fasta score E(): 5.8e-16, 63.9% identity in 83 aa overlap and Mycobacterium tuberculosis RV2441C SW:RL27_MYCTU (Z8145) (86 aa); Fasta score E(): 3.3e-28, 93.8% identity in 81 aa overlap. Contains Pfam match to entry PF01016 Ribosomal_L27, Ribosomal L27 protein. Contains PS00831 Ribosomal protein L27 signature; Belongs to the bacterial ribosomal protein bL27 family.
  
 
 0.957
rpsI
Similar to M. tuberculosis rpsI, 30S ribosomal protein S9, SW:RS9_MYCTU (O06259) (151 aa); Fasta score E(): 0, 83.2% identity in 155 aa overlap. Previously sequenced as SW:RS9_MYCLE (P40828) (153 aa); Fasta score E(): 0, 99.3% identity in 153 aa overlap. Contains Pfam match to entry PF00380 Ribosomal_S9, Ribosomal protein S9/S16. Contains PS00360 Ribosomal protein S9 signature; Belongs to the universal ribosomal protein uS9 family.
   
 
 0.955
ML1660
Conserved hypothetical protein; Similar to several proteins of undefined function e.g. Mycobacterium tuberculosis RV2926C TR:YT26_MYCTU; To M.tuberculosis Rv2926c.
  
  
 0.952
rpmF
Hypothetical protein (pseudogene); Probable ribosomal protein L32, rpmF,similar to many e.g. tr|Q9RL50|Q9RL50 PROBABLE 50S RIBOSOMAL PROTEIN (56 aa) E(): 1.5e-09; 63.462% identity in 52 aa overlap; Belongs to the bacterial ribosomal protein bL32 family.
  
   0.950
rplQ
Similar to M. tuberculosis 50S ribosomal protein L17 rplQ Rv3456c SW:RL17_MYCTU (O06323) (180 aa); Fasta score E(): 0, 81.9% identity in 171 aa overlap. Contains Pfam match to entry PF01196 Ribosomal_L17, Ribosomal protein L17.
   
 
 0.949
rpsP
Highly similar to many 30s ribosomal proteins (S16) including: Bacillus subtilis SW:RS16_BACSU (P21474) (89 aa); Fasta score E(): 2.1e-10, 45.1% identity in 82 aa overlap and Mycobacterium tuberculosis SW:RS16_MYCTU (Q10795) (162 aa); Fasta score E(): 0, 82.5% identity in 160 aa overlap. Contains Pfam match to entry PF00886 Ribosomal_S16, Ribosomal protein S16. Contains PS00732 Ribosomal protein S16 signature; Belongs to the bacterial ribosomal protein bS16 family.
  
 
 0.948
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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