STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML1892ABC transporter ATP-binding protein; Not known, could be involved in the transport of ribonucleotides. (338 aa)    
Predicted Functional Partners:
yrbE1B
Conserved membrane protein; Highly similar to several Mycobacterium tuberculosis hypothetical proteins found within the four Mce loci, associated with virulence, e.g. RV0168 TR:O07413 (EMBL:Z97050) fasta scores: E(): 0, 85.1% id in 289 aa. Orthologue of M. tuberculosis YrbE1B (Rv0168). Contains possible membrane spanning hydrophobic domains.
 
 0.996
yrbE1A
Conserved membrane protein; Highly similar to several Mycobacterium tuberculosis hypothetical proteins found within the four Mce loci, associated with virulence, e.g. RV0167 TR:O07412 (EMBL:Z97050) fasta scores: E(): 0, 88.5% id in 262 aa. Orthologue of M. tuberculosis YrbE1A (Rv0167). Contains possible membrane spanning hydrophobic domains.
 0.994
lprK
Putative lipoprotein; Highly similar to several Mycobacterium tuberculosis hypothetical proteins found within the four Mce loci, associated with virulence, e.g. RV0173 TR:O07417 (EMBL:Z97050) fasta scores: E(): 0, 76.3% id in 389 aa. Contains a possible N-terminal signal sequence and an appropriately positioned Prokaryotic membrane lipoprotein lipid attachment site. Orthologue of M. tuberculosis lprK (mce1E, Rv0173). Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
 
 0.987
mce1A
Putative cell invasion protein; Highly similar to Mycobacterium tuberculosis Mce proteins associated with entry and survival inside macrophage e.g. RV0169 ORMTCI28.08 TR:P72013 (EMBL:Z97050) fasta scores: E(): 0, 67.5% id in 456 aa.Orthologue of M. tuberculosis Mce1A (Rv0169). Contains a possible N-terminal signal sequence.
 
 0.982
mce1B
Putative secreted protein; Highly similar to several Mycobacterium tuberculosis hypothetical proteins found within the four Mce loci, associated with virulence, e.g. RV0170 TR:O07414 (EMBL:Z97050) fasta scores: E(): 0, 75.1% id in 346 aa. Orthologue of M. tuberculosis mce1B (Rv0170). Contains a possible N-terminal signal sequence.
 
 0.980
mce1D
Putative secreted protein; Highly similar to several Mycobacterium tuberculosis hypothetical proteins found within the four Mce loci, associated with virulence, e.g. RV0172 TR:O07416 (EMBL:Z97050) fasta scores: E(): 0, 78.1% id in 534 aa. Orthologue of M. tuberculosis Mce1D (Rv0172). Contains a possible N-terminal signal sequence.
 
 0.979
mce1C
Putative secreted protein; Highly similar to several Mycobacterium tuberculosis hypothetical proteins found within the four Mce loci, associated with virulence, e.g.RV0171 TR:O07415 (EMBL:Z97050) fasta scores: E(): 0, 72.4% id in 525 aa. Orthologue of M. tuberculosis Mce1C (Rv0171). Contains a possible N-terminal signal sequence.
 
 0.978
mce1F
Putative secreted protein; Highly similar to several Mycobacterium tuberculosis hypothetical proteins found within the four Mce loci, associated with virulence, e.g. RV0174 TR:O07418 (EMBL:Z97050) fasta scores: E(): 0, 76.5% id in 515 aa. Orthologue of M. tuberculosis Mce1F (Rv0174). Contains a possible N-terminal signal sequence.
 
 0.975
ML1390
Conserved hypothetical protein; Highly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis RV1636 TR:O06153 (EMBL:Z95554) (146 aa); Fasta score E(): 0, 89.0% identity in 146 aa overlap and Neisseria meningitidis TR:AAF41856 (EMBL:AE002499) (154 aa); Fasta score E(): 1.7e-07, 32.4% identity in 148 aa overlap. Contains Pfam match to entry PF00582 Usp, Universal stress protein family.
  
     0.601
gltB
Similar to M. tuberculosis Rv3859c, putative ferredoxin-dependent glutamate synthase, TR:P96218 (EMBL:Al123456) (1527 aa); Fasta score E(): 0, 90.2% identity in 1527 aa overlap and to Synechocystis sp. gltB, ferredoxin-dependent glutamate synthase 1, SW:GLTB_SYNY3 (P55037) (1550 aa); Fasta score E(): 0, 57.2% identity in 1525 aa overlap. Contains Pfam match to entry PF01493 DUF14, Domain of unknown function. Contains Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature.
       0.493
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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