STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
fbpBAntigen 85A, mycolyltransferase; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha- trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) [...] (327 aa)    
Predicted Functional Partners:
fbpC2
Secreted antigen 85A, mycolyltransferase; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria to fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha- trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolat [...]
  
  
0.941
fbpA
Antigen 85A, mycolytransferase; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan, and through the synthesis of alpha,alpha- trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) [...]
  
  
0.902
ML1244
Conserved membrane protein; Highly similar to a family of Mycobacterium tuberculosis proteins e.g. Rv2484c SW:YO84_MYCTU (O53209) (491 aa); Fasta score E(): 0, 75.2% identity in 483 aa overlap. Contains possible membrane spanning hydrophobic domains; Belongs to the long-chain O-acyltransferase family.
     
  0.900
ML0049
Possible secreted protein; A secreted protein that might play a role in virulence.
      
 0.792
ML2454
Possible hemagglutinin; Might mediate adherence to host cells by binding sulfated glycoconjugates.
  
   
 0.774
ML0099
Similar to M. tuberculosis Rv3802c, hypothetical protein, TR:O53581 (EMBL:AL123456) (336 aa); Fasta score E(): 0, 75.5% identity in 335 aa overlap.
  
     0.692
ML2295
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis putative alkaline serine protease Rv3668c or MTV025.016C TR:O69636 (EMBL:AL022121) (232 aa) fasta scores: E(): 0, 77.1% id in 231 aa. Shows weak similarity to the C-terminal half of some proteases e.g. Thermomonospora fusca alkaline serine protease precursor TR:O86984 (EMBL:U65895) (368 aa) fasta scores: E(): 0.0018, 31.4% id in 153 aa.
  
     0.674
ML1338
Possible conserved integral membrane protein; Similar to several membrane proteins e.g. Mycobacterium tuberculosis RV2673 TR:P71970 (EMBL:Z80225) (433 aa); Fasta score E(): 0, 82.0% identity in 434 aa overlap and weakly similar to Streptomyces coelicolor TR:Q53873 (EMBL:AL031317) (411 aa); Fasta score E(): 1.1e-12, 28.3% identity in 410 aa overlap. Contains multiple possible membrane spanning hydrophobic domains.
  
     0.649
ML1720
Conserved hypothetical protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV3035 TR:O53282 (EMBL:AL021287) (360 aa); Fasta score E(): 0, 75.8% identity in 363 aa overlap.
  
     0.649
adhE2
Putative alcohol dehydrogenase (Zn dependent); Similar to M. tuberculosis adhE2 Rv2259 TR:O53533 (EMBL:AL021925) (361 aa); Fasta score E(): 0, 88.9% identity in 361 aa overlap, and to other alcohol dehydrogenases e.g. Amycolatopsis methanolica NAD/mycothiol-dependent formaldehyde dehydrogenase SW:FADH_AMYME (P80094) (360 aa); Fasta score E(): 0, 80.4% identity in 358 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains PS00190 Cytochrome c family heme-binding site signature. Contains PS00059 Zinc-containing alcohol dehydrogenases signature; S [...]
  
 
 0.626
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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