STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glcBMalate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (731 aa)    
Predicted Functional Partners:
aceA
Isocitrate lyase; Involved in the persistence and virulence of Mycobacterium. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates.
 
 
 0.993
gltA2
Citrate synthase 1; Similar to Mycobacterium tuberculosis citrate synthase 1 SW:CISY_MYCTU (Q10530) fasta scores: E(): 0, 91.0% in 431 aa, and to Corynebacterium glutamicum citrate synthase SW:CISY_CORGL (P42457) fasta scores: E(): 0, 62.7% in 432 aa. Contains Pfam match to entry PF00285 citrate_synt, Citrate synthase. Contains PS00480 Citrate synthase signature.
   
 0.984
fum
Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
    
 0.978
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
   
 0.935
bccA
Acetyl/propionyl CoA carboxylase [alpha] subunit; This protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase.
   
 0.931
fadA4
Possible acetyl-CoA C-acetyltransferase; Identical to the previously sequenced Mycobacterium leprae probable acetyl-CoA acetyltransferase (EC 2.3.1.9) SW:THIL_MYCLE (P46707) (393 aa); Fasta score E(): 0, 100.0% identity in 393 aa overlap. Also highly similar to many others including: acetyl-CoA acetyltransferases from Alcaligenes eutrophus SW:THIL_ALCEU (P14611) (393 aa); Fasta score E(): 0, 50.4% identity in 389 aa overlap and Mycobacterium tuberculosis (FadA4) Rv1323 SW:THIL_MYCTU (Q10629) (389 aa); Fasta score E(): 0, 86.9% identity in 388 aa overlap. Contains Pfam match to entry PF [...]
   
 
 0.920
fadA
Similar to Mycobacterium tuberculosis putative beta-ketoadipyl CoA thiolase TR:O53871 (EMBL:AL022004) fasta scores: E(): 0, 94.5% in 403 aa, and to Escherichia coli acetyl-coa acetyltransferase TR:O53017 (EMBL:X97452) fasta scores: E(): 0, 44.1% in 422 aa, and to Acinetobacter calcoaceticus beta-ketoadipyl coa thiolase SW:PCAF_ACICA (Q43974) fasta scores: E(): 0, 40.9% in 425 aa. Contains Pfam match to entry PF00108 thiolase, Thiolase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00098 Thiolases acyl-enzyme intermediate signature. Contains PS00099 Thiolases active [...]
   
 
 0.920
fadA2
acetyl-CoA C-acetyltransferase; Similar to many Prokaryotic and Eukaryotic thiolases including: Escherichia coli probable 3-ketoacyl-coa thiolase YFCY SW:YFCY_ECOLI (P76503) fasta scores: E(): 0, 36.9% id in 434 aa and to Rattus norvegicus trifunctonal enzyme beta subunit, mitochondrial precursor SW:ECHB_RAT (Q60587) fasta scores: E(): 0, 37.2% id in 462 aa. Contains Pfam match to entry PF00108 thiolase, Thiolase. Contains PS00099 Thiolases active site; Belongs to the thiolase-like superfamily. Thiolase family.
   
 
 0.920
ML1103
Similar to many putative oxidoreductase subunits including: Escherichia coli glycolate oxidase subunit GlcD SW:GLCD_ECOLI (P52075) (499 aa); Fasta score E(): 0, 38.8% identity in 456 aa overlap and Mycobacterium tuberculosis probable oxidoreductase Rv1257c TR:Q11061 (EMBL:Z77137) (455 aa); Fasta score E(): 0, 85.8% identity in 451 aa overlap. Contains Pfam match to entry PF01565 FAD_binding_4, FAD binding domain.
  
 
 0.912
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
   
 
 0.906
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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