STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML2186Transcriptional regulator (NifR3/Smm1 family); Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. (384 aa)    
Predicted Functional Partners:
desA1
acyl-[ACP] desaturase; Similar to Mycobacterium tuberculosis protein desA1 TR:Q50824 (EMBL:U49839) fasta scores: E(): 0, 79.9% in 338 aa, and to Oryza sativa acyl-[acyl-carrier protein] desaturase precursor SW:STAD_ORYSA (Q40731) fasta scores: E(): 2e-19, 28.3% in 300 aa; Similar to and ML1952.
  
  
 0.948
ML0729
Conserved hypothetical protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
 
     0.760
desA2
Similar to M. tuberculosis acyl-[ACP] desaturase desA2 TR:O53442 (EMBL:AL021897) (275 aa); Fasta score E(): 0, 78.1% identity in 274 aa overlap, and to others e.g. Gossypium hirsutum (Upland cotton) acyl-[acyl-carrier protein] desaturase precursor SW:STAD_GOSHI (X95988) (397 aa); Fasta score E(): 5.6e-05, 23.9% identity in 293 aa overlap; Similar to and ML2185.
  
  
 0.686
proS
Prolyl tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
  
 
 0.676
gltS
glutamyl-tRNA synthase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
 
 
 0.545
fdxA
Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
   
    0.538
panC
Putative pantoate-[beta]-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
  
    0.508
guaA
Putative GMP synthase; Catalyzes the synthesis of GMP from XMP.
   
  
 0.441
truA
Probable pseudouridylate synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
  
 
 0.429
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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