STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
ML2193Putative acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. (311 aa)    
Predicted Functional Partners:
ML1495
Conserved hypothetical protein; Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2- deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.
  
   
 0.974
cysS2
cysteinyl-tRNA synthase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
 
   
 0.932
ML2443
Possible glycosyl transferase; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
  
   
 0.913
ML2391
Conserved hypothetical protein; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily.
  
   
 0.871
ML1681
Possible polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family.
      0.846
phoS3
Phosphate-binding protein 3 precursor; Part of the ABC transporter complex PstSACB involved in phosphate import; Belongs to the PstS family.
       0.797
ML1485
Conserved hypothetical protein; Highly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis RV2466C TR:O53193 (EMBL:AL02124) (207 aa); Fasta score E(): 0, 80.6% identity in 206 aa overlap and Streptomyces coelicolor TR:CAB71809 (EMBL:AL138662) (216 aa); Fasta score E(): 0, 52.3% identity in 214 aa overlap.
  
   0.795
phoT
Phosphate transport system ABC transporter; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
     
 0.777
ML0284
Similar to M. tuberculosis Rv0360c, hypothetical protein, TR:O06310 (EMBL:AL123456) (145 aa); Fasta score E(): 0, 85.4% identity in 137 aa overlap and Streptomyces coelicolor SCH10.25C, hypothetical protein, TR:Q9X8R4 (EMBL:AL049754) (143 aa); Fasta score E(): 8.2e-27, 56.2% identity in 130 aa overlap. Previously sequenced as TR:O69598 (EMBL:AL023514) (137 aa); Fasta score E(): 0, 100.0% identity in 137 aa overlap.
  
     0.658
nrdH
Highly similar to many glutaredoxin-like proteins involved in electron transport for the ribonucleotide reductase system NrdEF, including: Escherichia coli SW:NRDH_ECOLI (Q47414) (81 aa); Fasta score E(): 1.1e-11, 44.0% identity in 75 aa overlap and Mycobacterium tuberculosis RV3053C TR:P95106 (EMBL:Z83866) (79 aa); Fasta score E(): 7.7e-31, 91.1% identity in 79 aa overlap.
   
  
 0.557
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.