STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purDPhosphoribosylamine-glycine ligase; Similar to Mycobacterium tuberculosis phosphoribosylamine--glycine ligase PurD OR RV0772 OR MTCY369.17 SW:PUR2_MYCTU (P71827) fasta scores: E(): 0, 81.8% id in 418 aa, and to Salmonella typhimurium phosphoribosylamine--glycine ligase PurD SW:PUR2_SALTY (P26977) fasta scores: E(): 0, 43.2% id in 426 aa. Contains Pfam match to entry PF01071 GARS, Phosphoribosylglycinamide synthetase (GARS). Contains PS00184 Phosphoribosylglycinamide synthetase signature. (422 aa)    
Predicted Functional Partners:
purN
Putative phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 
 0.999
purM
Similar to Mycobacterium tuberculosis 5'-phosphoribosyl-5-aminoimidazole synthetase RV0809 TR:O53823 (EMBL:AL022004) fasta scores: E(): 0, 87.1% id in 364 aa, and to Bacillus subtilis phosphoribosylformylglycinamidine cyclo-ligase PURM SW:PUR5_BACSU (P12043) fasta scores: E(): 0, 46.4% id in 334 aa. Contains Pfam match to entry PF00586 AIRS, AIR synthase related protein.
  
 0.997
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
 
 0.996
purE
Phosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
 0.995
purC
Similar to Mycobacterium tuberculosis phosphoribosylaminoimidazole-succinocarboxamide synthase PURC OR RV0780 OR MTCY369.24 SW:PUR7_MYCTU (Q59566; P77904) fasta scores: E(): 0, 81.5% id in 297 aa, and to Haemophilus influenzae putative phosphoribosylaminoimidazole-succinocarboxamide synthase PURC OR HI1726 SW:PUR7_HAEIN (P43851) fasta scores: E(): 0, 46.0% id in 287 aa, and to Candida maltosa phosphoribosylamidoimidazole-succinocarboxamide synthase ADE1 SW:PUR7_CANMA (P27602) fasta scores: E(): 0, 45.1% id in 288 aa. Contains Pfam match to entry PF01259 SAICAR_synt, SAICAR synthetase. [...]
 
 
 0.990
purQ
Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...]
  
 0.981
purH
Similar to M. tuberculosis Rv0957, purH, putative phosphoribosylaminoimidazolecarboxamide formyltransferase.
 
 
 0.945
gcvB
Glycine decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
  
 0.941
ML1809
Conserved hypothetical protein; Similar to M. tuberculosis Rv1480 SW:YE80_MYCTU (P71761) (317 aa); Fasta score E(): 0, 87.5% identity in 311 aa overlap. Contains Pfam match to entry PF01882 DUF58, Protein of unknown function.
      
 0.933
purB
Adenylosuccinate lyase; Similar to Mycobacterium tuberculosis hypothetical 51.0 kda protein cy369.21b RV0777 OR MTCY369.21B TR:P71832 (EMBL:Z80226) fasta scores: E(): 0, 86.4% id in 472 aa, and to Saccharomyces cerevisiae adenylosuccinate lyase ADE13 OR YLR359W OR L8039.12 SW:PUR8_YEAST (Q05911) fasta scores: E(): 0, 34.5% id in 449 aa. Contains Pfam match to entry PF00206 lyase_1, Lyase. Contains PS00163 Fumarate lyases signature.
  
 
 0.918
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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