STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
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Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
ML2268Putative isomerase/racemase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (334 aa)    
Predicted Functional Partners:
menD
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
 
   
 0.964
menE
O-succinylbenzoic acid-CoA ligase; Similar to Mycobacterium tuberculosis MenE or RV0542C or MTCY25D10.21C TR:O06408 (EMBL:Z95558) fasta scores: E(): 0, 78.3% id in 359 aa, and to Escherichia coli o-succinylbenzoic acid--coa ligase MENE SW:MENE_ECOLI (P37353; P78253; P78178) fasta scores: E(): 7e-18, 30.0% id in 377 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature.
 
 
  0.936
menB
Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
 
   
 0.888
ML2269
Putative hydrolase; Similar to Mycobacterium tuberculosis hypothetical protein Rv0554 or MTCY25D10.33 TR:O06420 (EMBL:Z95558) (262 aa) fasta scores: E(): 0, 83.5% id in 261 aa. Shows weak similarity to various hydrolases e.g. Rhodococcus opacus 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase pcaL TR:O67982 (EMBL:AF003947) (400 aa) fasta scores: E(): 1.9e-11, 27.4% id in 266 aa. Also similar to oxidoreductases which have an alpha/beta hydrolase fold e.g. Streptomyces aureofaciens non-haem bromoperoxidase bpoA2 SW:BPA2_STRAU (P29715) (277 aa) fasta scores: E(): 1 [...]
     
 0.861
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
      
 0.700
ML2273
Putative ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
     
 0.625
ML2271
Putative membrane protein; Similar to Mycobacterium tuberculosis putative membrane protein Rv0556 or MTCY25D10.35 TR:O06422 (EMBL:Z95558) (171 aa) fasta scores: E(): 0, 79.2% id in 168 aa. Contains hydrophobic, possible membrane-spanning regions.
 
     0.538
ML2406
Probable 4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily.
 
   
 0.537
folB
Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin, 7,8-dihydromonapterin and 7,8- dihydroxanthopterin, respectively, in equal quantities. After longer incubation times the only product is 6-hydroxymethyl-7,8-dihydropterin.
      
 0.507
ML0242
Putative isopentenyl monophosphate kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
  
   
 0.474
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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