node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML2268 | ML2269 | gene:17576127 | gene:17576128 | Putative isomerase/racemase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | Putative hydrolase; Similar to Mycobacterium tuberculosis hypothetical protein Rv0554 or MTCY25D10.33 TR:O06420 (EMBL:Z95558) (262 aa) fasta scores: E(): 0, 83.5% id in 261 aa. Shows weak similarity to various hydrolases e.g. Rhodococcus opacus 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase pcaL TR:O67982 (EMBL:AF003947) (400 aa) fasta scores: E(): 1.9e-11, 27.4% id in 266 aa. Also similar to oxidoreductases which have an alpha/beta hydrolase fold e.g. Streptomyces aureofaciens non-haem bromoperoxidase bpoA2 SW:BPA2_STRAU (P29715) (277 aa) fasta scores: E(): 1 [...] | 0.861 |
ML2268 | ML2271 | gene:17576127 | gene:17576130 | Putative isomerase/racemase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | Putative membrane protein; Similar to Mycobacterium tuberculosis putative membrane protein Rv0556 or MTCY25D10.35 TR:O06422 (EMBL:Z95558) (171 aa) fasta scores: E(): 0, 79.2% id in 168 aa. Contains hydrophobic, possible membrane-spanning regions. | 0.538 |
ML2268 | ML2273 | gene:17576127 | gene:17576132 | Putative isomerase/racemase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | Putative ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). | 0.625 |
ML2268 | ML2406 | gene:17576127 | gene:17576268 | Putative isomerase/racemase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | Probable 4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | 0.537 |
ML2268 | entC | gene:17576127 | gene:17574633 | Putative isomerase/racemase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | Similar to Mycobacterium tuberculosis putative isochorismate synthase entC or Rv3215 or MTCY07D11.11c (372 aa) TR:O05851 (EMBL:Z95120) fasta scores: E(): 0, 73.5% id in 366 aa and to Bacillus subtilis isochorismate synthase dhbC (398 aa) SW:DHBC_BACSU (P45744) fasta scores: E(): 0, 37.9% id in 396 aa. The predicted CDS has an N-terminal extension of approx. 210 aa not present in known isochorismate synthases. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Similar to ML0236 and ML1269. | 0.470 |
ML2268 | menB | gene:17576127 | gene:17576122 | Putative isomerase/racemase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. | 0.888 |
ML2268 | menD | gene:17576127 | gene:17576129 | Putative isomerase/racemase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). | 0.964 |
ML2268 | menE | gene:17576127 | gene:17576116 | Putative isomerase/racemase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | O-succinylbenzoic acid-CoA ligase; Similar to Mycobacterium tuberculosis MenE or RV0542C or MTCY25D10.21C TR:O06408 (EMBL:Z95558) fasta scores: E(): 0, 78.3% id in 359 aa, and to Escherichia coli o-succinylbenzoic acid--coa ligase MENE SW:MENE_ECOLI (P37353; P78253; P78178) fasta scores: E(): 7e-18, 30.0% id in 377 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. | 0.936 |
ML2269 | ML2268 | gene:17576128 | gene:17576127 | Putative hydrolase; Similar to Mycobacterium tuberculosis hypothetical protein Rv0554 or MTCY25D10.33 TR:O06420 (EMBL:Z95558) (262 aa) fasta scores: E(): 0, 83.5% id in 261 aa. Shows weak similarity to various hydrolases e.g. Rhodococcus opacus 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase pcaL TR:O67982 (EMBL:AF003947) (400 aa) fasta scores: E(): 1.9e-11, 27.4% id in 266 aa. Also similar to oxidoreductases which have an alpha/beta hydrolase fold e.g. Streptomyces aureofaciens non-haem bromoperoxidase bpoA2 SW:BPA2_STRAU (P29715) (277 aa) fasta scores: E(): 1 [...] | Putative isomerase/racemase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | 0.861 |
ML2269 | ML2271 | gene:17576128 | gene:17576130 | Putative hydrolase; Similar to Mycobacterium tuberculosis hypothetical protein Rv0554 or MTCY25D10.33 TR:O06420 (EMBL:Z95558) (262 aa) fasta scores: E(): 0, 83.5% id in 261 aa. Shows weak similarity to various hydrolases e.g. Rhodococcus opacus 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase pcaL TR:O67982 (EMBL:AF003947) (400 aa) fasta scores: E(): 1.9e-11, 27.4% id in 266 aa. Also similar to oxidoreductases which have an alpha/beta hydrolase fold e.g. Streptomyces aureofaciens non-haem bromoperoxidase bpoA2 SW:BPA2_STRAU (P29715) (277 aa) fasta scores: E(): 1 [...] | Putative membrane protein; Similar to Mycobacterium tuberculosis putative membrane protein Rv0556 or MTCY25D10.35 TR:O06422 (EMBL:Z95558) (171 aa) fasta scores: E(): 0, 79.2% id in 168 aa. Contains hydrophobic, possible membrane-spanning regions. | 0.704 |
ML2269 | menB | gene:17576128 | gene:17576122 | Putative hydrolase; Similar to Mycobacterium tuberculosis hypothetical protein Rv0554 or MTCY25D10.33 TR:O06420 (EMBL:Z95558) (262 aa) fasta scores: E(): 0, 83.5% id in 261 aa. Shows weak similarity to various hydrolases e.g. Rhodococcus opacus 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase pcaL TR:O67982 (EMBL:AF003947) (400 aa) fasta scores: E(): 1.9e-11, 27.4% id in 266 aa. Also similar to oxidoreductases which have an alpha/beta hydrolase fold e.g. Streptomyces aureofaciens non-haem bromoperoxidase bpoA2 SW:BPA2_STRAU (P29715) (277 aa) fasta scores: E(): 1 [...] | Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. | 0.476 |
ML2269 | menD | gene:17576128 | gene:17576129 | Putative hydrolase; Similar to Mycobacterium tuberculosis hypothetical protein Rv0554 or MTCY25D10.33 TR:O06420 (EMBL:Z95558) (262 aa) fasta scores: E(): 0, 83.5% id in 261 aa. Shows weak similarity to various hydrolases e.g. Rhodococcus opacus 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase pcaL TR:O67982 (EMBL:AF003947) (400 aa) fasta scores: E(): 1.9e-11, 27.4% id in 266 aa. Also similar to oxidoreductases which have an alpha/beta hydrolase fold e.g. Streptomyces aureofaciens non-haem bromoperoxidase bpoA2 SW:BPA2_STRAU (P29715) (277 aa) fasta scores: E(): 1 [...] | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). | 0.722 |
ML2271 | ML2268 | gene:17576130 | gene:17576127 | Putative membrane protein; Similar to Mycobacterium tuberculosis putative membrane protein Rv0556 or MTCY25D10.35 TR:O06422 (EMBL:Z95558) (171 aa) fasta scores: E(): 0, 79.2% id in 168 aa. Contains hydrophobic, possible membrane-spanning regions. | Putative isomerase/racemase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | 0.538 |
ML2271 | ML2269 | gene:17576130 | gene:17576128 | Putative membrane protein; Similar to Mycobacterium tuberculosis putative membrane protein Rv0556 or MTCY25D10.35 TR:O06422 (EMBL:Z95558) (171 aa) fasta scores: E(): 0, 79.2% id in 168 aa. Contains hydrophobic, possible membrane-spanning regions. | Putative hydrolase; Similar to Mycobacterium tuberculosis hypothetical protein Rv0554 or MTCY25D10.33 TR:O06420 (EMBL:Z95558) (262 aa) fasta scores: E(): 0, 83.5% id in 261 aa. Shows weak similarity to various hydrolases e.g. Rhodococcus opacus 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase pcaL TR:O67982 (EMBL:AF003947) (400 aa) fasta scores: E(): 1.9e-11, 27.4% id in 266 aa. Also similar to oxidoreductases which have an alpha/beta hydrolase fold e.g. Streptomyces aureofaciens non-haem bromoperoxidase bpoA2 SW:BPA2_STRAU (P29715) (277 aa) fasta scores: E(): 1 [...] | 0.704 |
ML2271 | menD | gene:17576130 | gene:17576129 | Putative membrane protein; Similar to Mycobacterium tuberculosis putative membrane protein Rv0556 or MTCY25D10.35 TR:O06422 (EMBL:Z95558) (171 aa) fasta scores: E(): 0, 79.2% id in 168 aa. Contains hydrophobic, possible membrane-spanning regions. | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). | 0.814 |
ML2273 | ML2268 | gene:17576132 | gene:17576127 | Putative ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). | Putative isomerase/racemase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | 0.625 |
ML2273 | ML2406 | gene:17576132 | gene:17576268 | Putative ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). | Probable 4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | 0.921 |
ML2273 | entC | gene:17576132 | gene:17574633 | Putative ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). | Similar to Mycobacterium tuberculosis putative isochorismate synthase entC or Rv3215 or MTCY07D11.11c (372 aa) TR:O05851 (EMBL:Z95120) fasta scores: E(): 0, 73.5% id in 366 aa and to Bacillus subtilis isochorismate synthase dhbC (398 aa) SW:DHBC_BACSU (P45744) fasta scores: E(): 0, 37.9% id in 396 aa. The predicted CDS has an N-terminal extension of approx. 210 aa not present in known isochorismate synthases. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Similar to ML0236 and ML1269. | 0.443 |
ML2273 | menD | gene:17576132 | gene:17576129 | Putative ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). | 0.778 |
ML2406 | ML2268 | gene:17576268 | gene:17576127 | Probable 4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | Putative isomerase/racemase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | 0.537 |