STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
recRDNA repair protein; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (203 aa)    
Predicted Functional Partners:
ML0633
Conserved hypothetical protein; Involved in DNA repair and RecF pathway recombination.
 
 
 0.981
ML2330
Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
 
  
 0.965
recF
Putative DNA replication and SOS induction protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity).
 
  
 0.925
ML2331
Possible secreted protein; Similar to Mycobacterium tuberculosis hypothetical 24.8 kDa protein Rv3717 TR:O69684 (EMBL:AL022121) (241 aa) fasta scores: E(): 0, 82.0% id in 244 aa, and to Streptomyces coelicolor putative secreted protein TR:CAB93433 (EMBL:AL357591) (336 aa) fasta scores: E(): 1.5e-24, 38.8% id in 242 aa. Note contains a Pfam match to PF01520 N-acetylmuramoyl-L-alanine amidase. Contains Pfam match to entry PF01520 Amidase_3, N-acetylmuramoyl-L-alanine amidase. Contains a possible N-terminal signal sequence.
     
 0.792
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity).
     
 0.715
cinA
Similar to M. tuberculosis competence damage protein homolog cinA Rv1901 TR:O07731 (EMBL:Z97193) (430 aa); Fasta score E(): 0, 77.0% identity in 431 aa overlap, and to e.g. Streptococcus pneumoniae putative competence-damage protein SW:CINA_STRPN (P54184) (418 aa); Fasta score E(): 1.4e-22, 31.0% identity in 439 aa overlap; Belongs to the CinA family.
  
  
 0.688
ML0044
Conserved hypothetical protein (pseudogene); Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection; Belongs to the YbaB/EbfC family.
  
  
 0.671
ML0997
Possible ATP/GTP-binding protein; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
      
 0.662
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
  
   
 0.642
recN
Recombination and DNA repair; May be involved in recombinational repair of damaged DNA.
     
 0.632
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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