node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML2349 | ML2350 | gene:17576211 | gene:17576212 | Conserved hypothetical protein; Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols. Belongs to the acyltransferase PapA5 family. | Probable antibiotic resistance membrane protein; Similar to several antibiotic resistant proteins including: Mycobacterium tuberculosis rv2938 TR:P96207 (EMBL:Z83857) (276 aa) fasta scores: E(): 0, 79.0% id in 276 aa and Streptomyces peucetius daunorubicin resistance transmembrane protein DrrB SW:DRRB_STRPE (P32011) (283 aa) fasta scores: E(): 2.7e-11, 23.8% id in 252 aa. Contains possible membrane spanning hydrophobic domains; Similar to the adjoining CDS ML2351. | 0.891 |
ML2349 | ML2351 | gene:17576211 | gene:17576213 | Conserved hypothetical protein; Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols. Belongs to the acyltransferase PapA5 family. | Probable antibiotic resistance membrane protein; Similar to several antibiotic resistant proteins including: Mycobacterium tuberculosis Rv2937 TR:P96206 (EMBL:Z83857) (289 aa) fasta scores: E(): 0, 64.0% id in 289 aa and Streptomyces peucetius daunorubicin resistance transmembrane protein DrrB SW:DRRB_STRPE (P32011) (283 aa) fasta scores: E(): 4.2e-06, 22.7% id in 229 aa. Contains possible membrane spanning hydrophobic domains; Similar to the adjoining CDS ML2350. | 0.912 |
ML2349 | ML2352 | gene:17576211 | gene:17576214 | Conserved hypothetical protein; Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols. Belongs to the acyltransferase PapA5 family. | Probable antibiotic resistance efflux protein; Similar to several antibiotic resistant proteins including: Mycobacterium tuberculosis Rv2936 TR:P96205 (EMBL:Z83857) (331 aa) fasta scores: E(): 0, 85.2% id in 331 aa and Streptomyces peucetius daunorubicin resistance ATP-binding protein DrrA SW:DRRA_STRPE (P32010) (330 aa) fasta scores: E(): 0, 46.0% id in 322 aa. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00211 ABC transporters family signature. | 0.833 |
ML2349 | ML2353 | gene:17576211 | gene:17576215 | Conserved hypothetical protein; Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols. Belongs to the acyltransferase PapA5 family. | Similar to many polyketide synthases e.g. Mycobacterium tuberculosis Rv2935 TR:P96204 (EMBL:Z83857) (1488 aa) fasta scores: E(): 0, 82.0% id in 1493 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00606 Beta-ketoacyl synthases active site; Similar to ML2355, ML0139, ML0135, ML2354, ML2356, ML2357, ML1229 and ML0101. | 0.804 |
ML2349 | ML2354 | gene:17576211 | gene:17576216 | Conserved hypothetical protein; Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols. Belongs to the acyltransferase PapA5 family. | Similar to many polyketide synthases e.g.Mycobacterium tuberculosis Rv2934 TR:P96203 (EMBL:Z83857) (1827 aa) fasta scores: E(): 0, 80.3% id in 1836 aa, and to Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa) fasta scores: E(): 0, 32.7% id in 2136 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00017 ATP/G [...] | 0.776 |
ML2349 | ML2355 | gene:17576211 | gene:17576217 | Conserved hypothetical protein; Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols. Belongs to the acyltransferase PapA5 family. | Similar to several polyketide synthases e.g. Mycobacterium tuberculosis Rv2933 TR:P96202 (EMBL:Z83857) (2188 aa) fasta scores: E(): 0, 82.3% id in 2217 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00133 Zinc carboxypeptidases. Contains PS00606 Beta-ketoacyl [...] | 0.846 |
ML2349 | ML2356 | gene:17576211 | gene:17576218 | Conserved hypothetical protein; Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols. Belongs to the acyltransferase PapA5 family. | Similar to many polyketide synthases including: Mycobacterium tuberculosis phenolpthiocerol synthesis polyketide synthase Rv2932 SW:PPSB_MYCTU (Q10978; O53234) (1538 aa) fasta scores: E(): 0, 76.3% id in 1561 aa and Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa) fasta scores: E(): 0, 42.2% id in 879 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00606 Be [...] | 0.831 |
ML2349 | ML2357 | gene:17576211 | gene:17576219 | Conserved hypothetical protein; Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols. Belongs to the acyltransferase PapA5 family. | Polyketide synthase; Highly similar to many Prokaryotic and Eukaryotic polyketide synthases including: Mycobacterium tuberculosis phenolpthiocerol synthase rv2931 SW:PPSA_MYCTU (Q10977) (1876 aa) fasta scores: E(): 0, 76.1% id in 1888 aa and to Penicillium patulum 6-methylsalicylic acid synthase SW:MSAS_PENPA (P22367) (1774 aa) fasta scores: E(): 0, 33.8% id in 1823 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains 2 Pfam matches to entry PF00550 pp-binding, Phosphopantethe [...] | 0.834 |
ML2349 | mmpL7 | gene:17576211 | gene:17573952 | Conserved hypothetical protein; Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols. Belongs to the acyltransferase PapA5 family. | Putative membrane protein; Similar to members of the M. tuberculosis mmpL family of membrane proteins e.g. Rv2942, mmpL7, putative membrane protein, SW:MML7_MYCTU (P96289) (920 aa); Fasta score E(): 0, 68.6% identity in 881 aa overlap. Contains hydrophobic, possible membrane-spanning regions; Similar to ML1231 and ML2378. Similar to pseudogene ML2375. | 0.842 |
ML2349 | pks13 | gene:17576211 | gene:17573913 | Conserved hypothetical protein; Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols. Belongs to the acyltransferase PapA5 family. | Similar to many polyketide synthases from M. tuberculosis e.g. ppsA, M. tuberculosis phenolpthiocerol synthesis polyketide synthase, SW:PPSA_MYCTU (Q10977) (1876 aa); Fasta score E(): 0, 36.1% identity in 1277 aa overlap. Similar to many others e.g. Streptomyces noursei nysI, nystatin biosynthesis polyketide synthase, TR:AAF71766 (EMBL:AF263912) (9477 aa); Fasta score E(): 0, 33.4% identity in 1215 aa overlap. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entr [...] | 0.815 |
ML2350 | ML2349 | gene:17576212 | gene:17576211 | Probable antibiotic resistance membrane protein; Similar to several antibiotic resistant proteins including: Mycobacterium tuberculosis rv2938 TR:P96207 (EMBL:Z83857) (276 aa) fasta scores: E(): 0, 79.0% id in 276 aa and Streptomyces peucetius daunorubicin resistance transmembrane protein DrrB SW:DRRB_STRPE (P32011) (283 aa) fasta scores: E(): 2.7e-11, 23.8% id in 252 aa. Contains possible membrane spanning hydrophobic domains; Similar to the adjoining CDS ML2351. | Conserved hypothetical protein; Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols. Belongs to the acyltransferase PapA5 family. | 0.891 |
ML2350 | ML2351 | gene:17576212 | gene:17576213 | Probable antibiotic resistance membrane protein; Similar to several antibiotic resistant proteins including: Mycobacterium tuberculosis rv2938 TR:P96207 (EMBL:Z83857) (276 aa) fasta scores: E(): 0, 79.0% id in 276 aa and Streptomyces peucetius daunorubicin resistance transmembrane protein DrrB SW:DRRB_STRPE (P32011) (283 aa) fasta scores: E(): 2.7e-11, 23.8% id in 252 aa. Contains possible membrane spanning hydrophobic domains; Similar to the adjoining CDS ML2351. | Probable antibiotic resistance membrane protein; Similar to several antibiotic resistant proteins including: Mycobacterium tuberculosis Rv2937 TR:P96206 (EMBL:Z83857) (289 aa) fasta scores: E(): 0, 64.0% id in 289 aa and Streptomyces peucetius daunorubicin resistance transmembrane protein DrrB SW:DRRB_STRPE (P32011) (283 aa) fasta scores: E(): 4.2e-06, 22.7% id in 229 aa. Contains possible membrane spanning hydrophobic domains; Similar to the adjoining CDS ML2350. | 0.988 |
ML2350 | ML2352 | gene:17576212 | gene:17576214 | Probable antibiotic resistance membrane protein; Similar to several antibiotic resistant proteins including: Mycobacterium tuberculosis rv2938 TR:P96207 (EMBL:Z83857) (276 aa) fasta scores: E(): 0, 79.0% id in 276 aa and Streptomyces peucetius daunorubicin resistance transmembrane protein DrrB SW:DRRB_STRPE (P32011) (283 aa) fasta scores: E(): 2.7e-11, 23.8% id in 252 aa. Contains possible membrane spanning hydrophobic domains; Similar to the adjoining CDS ML2351. | Probable antibiotic resistance efflux protein; Similar to several antibiotic resistant proteins including: Mycobacterium tuberculosis Rv2936 TR:P96205 (EMBL:Z83857) (331 aa) fasta scores: E(): 0, 85.2% id in 331 aa and Streptomyces peucetius daunorubicin resistance ATP-binding protein DrrA SW:DRRA_STRPE (P32010) (330 aa) fasta scores: E(): 0, 46.0% id in 322 aa. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00211 ABC transporters family signature. | 0.997 |
ML2350 | ML2353 | gene:17576212 | gene:17576215 | Probable antibiotic resistance membrane protein; Similar to several antibiotic resistant proteins including: Mycobacterium tuberculosis rv2938 TR:P96207 (EMBL:Z83857) (276 aa) fasta scores: E(): 0, 79.0% id in 276 aa and Streptomyces peucetius daunorubicin resistance transmembrane protein DrrB SW:DRRB_STRPE (P32011) (283 aa) fasta scores: E(): 2.7e-11, 23.8% id in 252 aa. Contains possible membrane spanning hydrophobic domains; Similar to the adjoining CDS ML2351. | Similar to many polyketide synthases e.g. Mycobacterium tuberculosis Rv2935 TR:P96204 (EMBL:Z83857) (1488 aa) fasta scores: E(): 0, 82.0% id in 1493 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00606 Beta-ketoacyl synthases active site; Similar to ML2355, ML0139, ML0135, ML2354, ML2356, ML2357, ML1229 and ML0101. | 0.950 |
ML2350 | ML2354 | gene:17576212 | gene:17576216 | Probable antibiotic resistance membrane protein; Similar to several antibiotic resistant proteins including: Mycobacterium tuberculosis rv2938 TR:P96207 (EMBL:Z83857) (276 aa) fasta scores: E(): 0, 79.0% id in 276 aa and Streptomyces peucetius daunorubicin resistance transmembrane protein DrrB SW:DRRB_STRPE (P32011) (283 aa) fasta scores: E(): 2.7e-11, 23.8% id in 252 aa. Contains possible membrane spanning hydrophobic domains; Similar to the adjoining CDS ML2351. | Similar to many polyketide synthases e.g.Mycobacterium tuberculosis Rv2934 TR:P96203 (EMBL:Z83857) (1827 aa) fasta scores: E(): 0, 80.3% id in 1836 aa, and to Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa) fasta scores: E(): 0, 32.7% id in 2136 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00017 ATP/G [...] | 0.790 |
ML2350 | ML2355 | gene:17576212 | gene:17576217 | Probable antibiotic resistance membrane protein; Similar to several antibiotic resistant proteins including: Mycobacterium tuberculosis rv2938 TR:P96207 (EMBL:Z83857) (276 aa) fasta scores: E(): 0, 79.0% id in 276 aa and Streptomyces peucetius daunorubicin resistance transmembrane protein DrrB SW:DRRB_STRPE (P32011) (283 aa) fasta scores: E(): 2.7e-11, 23.8% id in 252 aa. Contains possible membrane spanning hydrophobic domains; Similar to the adjoining CDS ML2351. | Similar to several polyketide synthases e.g. Mycobacterium tuberculosis Rv2933 TR:P96202 (EMBL:Z83857) (2188 aa) fasta scores: E(): 0, 82.3% id in 2217 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00133 Zinc carboxypeptidases. Contains PS00606 Beta-ketoacyl [...] | 0.952 |
ML2350 | ML2356 | gene:17576212 | gene:17576218 | Probable antibiotic resistance membrane protein; Similar to several antibiotic resistant proteins including: Mycobacterium tuberculosis rv2938 TR:P96207 (EMBL:Z83857) (276 aa) fasta scores: E(): 0, 79.0% id in 276 aa and Streptomyces peucetius daunorubicin resistance transmembrane protein DrrB SW:DRRB_STRPE (P32011) (283 aa) fasta scores: E(): 2.7e-11, 23.8% id in 252 aa. Contains possible membrane spanning hydrophobic domains; Similar to the adjoining CDS ML2351. | Similar to many polyketide synthases including: Mycobacterium tuberculosis phenolpthiocerol synthesis polyketide synthase Rv2932 SW:PPSB_MYCTU (Q10978; O53234) (1538 aa) fasta scores: E(): 0, 76.3% id in 1561 aa and Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa) fasta scores: E(): 0, 42.2% id in 879 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00606 Be [...] | 0.810 |
ML2350 | ML2357 | gene:17576212 | gene:17576219 | Probable antibiotic resistance membrane protein; Similar to several antibiotic resistant proteins including: Mycobacterium tuberculosis rv2938 TR:P96207 (EMBL:Z83857) (276 aa) fasta scores: E(): 0, 79.0% id in 276 aa and Streptomyces peucetius daunorubicin resistance transmembrane protein DrrB SW:DRRB_STRPE (P32011) (283 aa) fasta scores: E(): 2.7e-11, 23.8% id in 252 aa. Contains possible membrane spanning hydrophobic domains; Similar to the adjoining CDS ML2351. | Polyketide synthase; Highly similar to many Prokaryotic and Eukaryotic polyketide synthases including: Mycobacterium tuberculosis phenolpthiocerol synthase rv2931 SW:PPSA_MYCTU (Q10977) (1876 aa) fasta scores: E(): 0, 76.1% id in 1888 aa and to Penicillium patulum 6-methylsalicylic acid synthase SW:MSAS_PENPA (P22367) (1774 aa) fasta scores: E(): 0, 33.8% id in 1823 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains 2 Pfam matches to entry PF00550 pp-binding, Phosphopantethe [...] | 0.826 |
ML2350 | mmpL7 | gene:17576212 | gene:17573952 | Probable antibiotic resistance membrane protein; Similar to several antibiotic resistant proteins including: Mycobacterium tuberculosis rv2938 TR:P96207 (EMBL:Z83857) (276 aa) fasta scores: E(): 0, 79.0% id in 276 aa and Streptomyces peucetius daunorubicin resistance transmembrane protein DrrB SW:DRRB_STRPE (P32011) (283 aa) fasta scores: E(): 2.7e-11, 23.8% id in 252 aa. Contains possible membrane spanning hydrophobic domains; Similar to the adjoining CDS ML2351. | Putative membrane protein; Similar to members of the M. tuberculosis mmpL family of membrane proteins e.g. Rv2942, mmpL7, putative membrane protein, SW:MML7_MYCTU (P96289) (920 aa); Fasta score E(): 0, 68.6% identity in 881 aa overlap. Contains hydrophobic, possible membrane-spanning regions; Similar to ML1231 and ML2378. Similar to pseudogene ML2375. | 0.443 |
ML2351 | ML2349 | gene:17576213 | gene:17576211 | Probable antibiotic resistance membrane protein; Similar to several antibiotic resistant proteins including: Mycobacterium tuberculosis Rv2937 TR:P96206 (EMBL:Z83857) (289 aa) fasta scores: E(): 0, 64.0% id in 289 aa and Streptomyces peucetius daunorubicin resistance transmembrane protein DrrB SW:DRRB_STRPE (P32011) (283 aa) fasta scores: E(): 4.2e-06, 22.7% id in 229 aa. Contains possible membrane spanning hydrophobic domains; Similar to the adjoining CDS ML2350. | Conserved hypothetical protein; Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phthiocerol, phthiodiolone and phenolphthiocerol dimycocerosate esters (PDIM) synthesis. Can directly transfer the mycocerosate bound to the mycocerosic acid synthase (mas) onto the substrate alcohols. Belongs to the acyltransferase PapA5 family. | 0.912 |