STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (467 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.998
hemL
Similar to Mycobacterium tuberculosis glutamate-1-semialdehyde 2,1-aminomutase HemL Rv0524 SW:GSA_MYCTU (O06390) (462 aa) fasta scores: E(): 0, 82.4% id in 460 aa, and to Escherichia coli glutamate-1-semialdehyde 2,1-aminomutase HemL SW:GSA_ECOLI (P23893; P78277) (426 aa) fasta scores: E(): 0, 53.0% id in 419 aa. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; Similar to ML1409.
 
 0.996
hemD
Possible uroporphyrin-III C-methyltransferase; Similar to Mycobacterium tuberculosis Rv0511 TR:P95077 (EMBL:Z83865) (565 aa) fasta scores: E(): 0, 85.7% id in 565 aa and to Clostridium josui porphyrin biosynthesis protein HemD [includes: uroporphyrin-III C-methyltransferase hemD SW:HEM4_CLOJO (Q59294) (504 aa) fasta scores: E(): 3e-24, 24.4% id in 545 aa. Contains Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases.
 
  
 0.993
hemB
[delta]-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family.
 
  
 0.987
gltS
glutamyl-tRNA synthase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
     
 0.971
ML2412
Similar to Mycobacterium tuberculosis hypothetical protein Rv0526 TR:O06392 (EMBL:Z95558) (216 aa) fasta scores: E(): 0, 78.5% id in 214 aa.
     
 0.761
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.757
ML2411
Possible cytochrome C-type biogenesis protein; Similar to Mycobacterium tuberculosis hypothetical protein Rv0527 TR:O06393 (EMBL:Z95558) (259 aa) fasta scores: E(): 0, 79.0% id in 262 aa, and to Bacillus subtilis cytochrome C-type biogenesis protein SW:CCDA_BACSU (P45706) (235 aa) fasta scores: E(): 9e-08, 28.9% id in 242 aa. Contains multiple possible membrane spanning hydrophobic domains.
     
 0.729
ML1728
Cytochrome C oxidase, polypeptide I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).
      
 0.715
ctaE
Cytochrome C oxidase subunit III; Similar to Mycobacterium tuberculosis probable cytochrome C oxidase polypeptide III ctaE or Rv2193 or MTCY190.04 SW:COX3_MYCTU (Q10385) (203 aa) fasta scores: E(): 0, 90.1% id in 203 aa. Similar to many e.g. Synechococcus vulcanus cytochrome C oxidase polypeptide III ctaE SW:COX3_SYNVU (P50677) (201 aa) fasta scores: E(): 1.2e-23, 39.0% id in 200 aa. Previously sequenced as TR:O69582 (EMBL:AL022602). Contains hydrophobic, probable membrane-spanning regions. Contains Pfam match to entry PF00510 COX3, Cytochrome c oxidase subunit III.
     
 0.714
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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