STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurrence
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Experiments
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[Homology]
Score
ML2443Possible glycosyl transferase; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway. (428 aa)    
Predicted Functional Partners:
ML1495
Conserved hypothetical protein; Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2- deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.
  
 0.957
ML2193
Putative acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
  
   
 0.913
cysS2
cysteinyl-tRNA synthase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
  
   
 0.880
ML2391
Conserved hypothetical protein; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily.
 
  
 0.815
ML2442
Similar to Mycobacterium tuberculosis hypothetical protein Rv0487 SW:Y487_MYCTU (Q11153) (183 aa) fasta scores: E(): 0, 69.2% id in 172 aa; To M.tuberculosis Rv0487.
 
     0.812
ML1070
Putative TetR-family transcriptional regulator; Identical to the previously sequenced Mycobacterium leprae TR:Q49962 (EMBL:U15180) (217 aa); Fasta score E(): 0, 100.0% identity in 217 aa overlap. Also highly similar to many proteins of undefined function e.g. Mycobacterium tuberculosis possible regulatory protein Rv3855 TR:P96222 (EMBL:Z83864) (216 aa); Fasta score E(): 0, 60.4% identity in 202 aa overlap. Contains a probable helix-turn-helix motif at aa 49-70 (Score 1321, SD +3.69) Contains Pfam match to entry PF00440 tetR, Bacterial regulatory proteins, tetR family; Similar to ML0064.
      
 0.782
gpm
Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
  
    0.753
ML1492
Conserved hypothetical protein; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine; In the C-terminal section; belongs to the radical SAM superfamily. CofH family.
      
 0.749
ML2439
Probable two-component system response regulator; Probably forms part of a two-component regulatory system RegX3/SenX3.
 
     0.673
ML2440
Probable two-component system sensor histidine kinase; Probably forms part of a two-component regulatory system SenX3/RegX3. Phosphorylates RegX3 (Probable).
  
    0.658
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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