STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pckAPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (609 aa)    
Predicted Functional Partners:
ppc
Putative phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
     
 0.956
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
     
 0.935
pykA
Pyruvate kinase; Highly similar to many pyruvate kinases (EC 2.7.1.40) including: Mycobacterium tuberculosis RV1617 SW:KPYK_MYCTU (O06134) (472 aa); Fasta score E(): 0, 90.7% identity in 472 aa overlap and Corynebacterium glutamicum SW:KPYK_CORGL (Q46078) (475 aa); Fasta score E(): 0, 71.8% identity in 468 aa overlap. Contains Pfam match to entry PF00224 PK, Pyruvate kinase. Contains PS00110 Pyruvate kinase active site signature.
   
 
 0.930
gltA2
Citrate synthase 1; Similar to Mycobacterium tuberculosis citrate synthase 1 SW:CISY_MYCTU (Q10530) fasta scores: E(): 0, 91.0% in 431 aa, and to Corynebacterium glutamicum citrate synthase SW:CISY_CORGL (P42457) fasta scores: E(): 0, 62.7% in 432 aa. Contains Pfam match to entry PF00285 citrate_synt, Citrate synthase. Contains PS00480 Citrate synthase signature.
   
 
 0.926
ppdK
Pyruvate, phosphate dikinase; Identical to the previously sequenced Mycobacterium leprae pyruvate, phosphate dikinase TR:O05566 (EMBL:Z94723) (601 aa); Fasta score E(): 0, 99.8% identity in 601 aa overlap. Also highly similar to pyruvate, phosphate dikinases from Mycobacterium tuberculosis TR:O06579 (EMBL:Z95585) (490 aa); Fasta score E(): 0, 71.8% identity in 478 aa overlap and Clostridium symbiosumSW:PODK_CLOSY (P22983) (873 aa); Fasta score E(): 0, 35.2% identity in 537 aa overlap. Contains Pfam match to entry PF00391 PEP-utilizers, PEP-utilizing enzymes. Contains Pfam match to entr [...]
     
 0.920
eno
Putative enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
     
 0.909
glcB
Malate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
     
 0.853
gabD
Succinate-semialdehyde dehydrogenase; Catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate. It is believed to be the main source of succinate semialdehyde dehydrogenase activity in Mycobacterium (By similarity).
   
 
 0.811
aceE
Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
   
 
 0.809
nadB
L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate.
     
 0.802
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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