STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML2640Conserved hypothetical protein; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity. (310 aa)    
Predicted Functional Partners:
ML2639
Aldehyde dehydrogenase; Similar to many Prokaryotic and Eukaryotic aldehyde dehydrogenases including: Mycobacterium tuberculosis hypothetical 55.0 kda protein RV0147 TR:P96824 (EMBL:Z92770) fasta scores: E(): 0, 77.1% id in 493 aa and Homo sapiens aldehyde dehydrogenase, dimeric NADP-preferring ALDH3 SW:DHAP_HUMAN (P30838) fasta scores: E(): 0, 44.7% id in 450 aa. Contains Pfam match to entry PF00171 aldedh, Aldehyde dehydrogenase family. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site.
       0.700
ML2529
Conserved membrane protein; Similar to Mycobacterium tuberculosis hypothetical protein RV0290 TR:O86362 (EMBL:AL021930) fasta scores: E(): 0, 76.4% id in 471 aa, and to Streptomyces coelicolor putative integral membrane protein SC3C3.21 TR:O86654 (EMBL:AL031231) fasta scores: E(): 1.9e-05, 23.8% id in 483 aa. Contains multiple possible membrane spanning hydrophobic domains towards the C-terminus.
  
     0.629
fadD9
Putative acyl-CoA synthetase; Similar to M. tuberculosis fadD9, Rv2590, putative acyl-CoA synthetase, TR:Q5063 (EMBL:Al123456) (1168 aa); Fasta score E(): 0, 68.0% identity in 1178 aa overlap1. Similar to acyl-CoA ligases and to domains of polyketide/peptide synthetases e.g. Mycobacterium smegmatis mps, peptide synthetase, TR:Q9RLP6 (EMBL:AJ238027) (5990 aa); Fasta score E(): 0, 37.2% identity in 1168 aa overlap. C-terminal half is similar to eukaryotic aminoadipate-semialdehyde dehydrogenase e.g. Saccharomyces cerevisiae lys2, aminoadipate-semialdehyde dehydrogenase large subunit, SW: [...]
  
     0.554
ML2536
Conserved membrane protein; Similar to several Mycobacterium tuberculosis hypothetical proteins e.g. RV0283 TR:O53688 (EMBL:AL021930) fasta scores: E(): 0, 70.8% id in 552 aa. Contains a possible membrane spanning hydrophobic domain; Similar to ML1544.
  
     0.487
ML2705
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 26.6 kda protein Rv3916c TR:O53594 (EMBL:AL021426) fasta scores: E(): 0, 76.4% in 250 aa, and to Streptomyces coelicolor hypothetical 22.6 kda protein TR:Q9R3S2 (EMBL:AF187159) fasta scores: E(): 1e-08, 39.7% in 237 aa.
  
     0.477
ML2535
Similar to Mycobacterium tuberculosis hypothetical protein RV0284 TR:O53689 (EMBL:AL021930) fasta scores: E(): 0, 84.2% id in 1318 aa and to Streptomyces coelicolor ATP/GTP binding protein SC3C3.20C TR:O86653 (EMBL:AL031231) fasta scores: E(): 0, 36.0% id in 1379 aa. Also similar in regions to several cell division proteins e.g. Coxiella burnetii cell division protein, FtsK homologue, SW:FTSK_COXBU (P39920) E(): 4.2e-07 28.3% id in 304. Contains a possible membrane spanning hydrophobic domain. Contains 2 Pfam matches to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family. Contains 3 x PS00 [...]
  
    0.432
lpqF
Probale secreted protein; Similar to M. tuberculosis lipoprotein Rv3593 lpqF TR:O06155 (EMBL:Z95555) (452 aa); Fasta score E(): 0, 79.2% identity in 451 aa overlap, and weakly to several beta-lactamase proteins e.g. Xanthomonas maltophilia chromosomic class A beta-lactamase TR:Q9X5A7 (EMBL:AF123246) (304 aa); Fasta score E(): 0.019, 26.2% identity in 260 aa overlap.
  
     0.420
ML1120
Conserved hypothetical protein; Highly similar to Mycobacterium tuberculosis hypothetical protein Rv1278 SW:YC78_MYCTU (Q11042) (875 aa); Fasta score E(): 0, 69.5% identity in 872 aa overlap. Contains multiple possible coiled-coils. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
  
     0.416
ML0069
Similar to M. tuberculosis Rv3849, hypothetical protein, TR:P96228 (EMBL:AL123456) (132 aa); Fasta score E(): 0, 84.0% identity in 131 aa overlap.
  
     0.411
ML2321
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 36.5 kDa protein Rv3707c TR:O69675 (EMBL:AL022121) (336 aa) fasta scores: E(): 0, 81.6% id in 332 aa, and to Mycobacterium smegmatis hypothetical 35.9 kDa protein in asd 3'region SW:YASD_MYCSM (P41402) (333 aa) fasta scores: E(): 0, 70.8% id in 332 aa.
  
     0.405
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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