node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MYPU_0020 | MYPU_3390 | gene:17576581 | gene:17576930 | DNA POLYMERASE III, BETA CHAIN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.494 |
MYPU_0020 | MYPU_5380 | gene:17576581 | gene:17577140 | DNA POLYMERASE III, BETA CHAIN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | THYMIDYLATE SYNTHASE (TS) (TSASE); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.789 |
MYPU_0020 | MYPU_5410 | gene:17576581 | gene:17577143 | DNA POLYMERASE III, BETA CHAIN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA CHAIN (RIBONUCLEOTIDE REDUCTASE); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.804 |
MYPU_0520 | MYPU_0550 | gene:17576631 | gene:17576635 | THYMIDYLATE KINASE (DTMP KINASE); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 5'-NUCLEOTIDASE PRECURSOR; Identified by sequence similarity; putative; similar to SWISS-PROT:P22848 (5NTD_VIBPA) Blastp2 P=5e-36 C=42%; Belongs to the 5'-nucleotidase family. | 0.911 |
MYPU_0520 | MYPU_1450 | gene:17576631 | gene:17576729 | THYMIDYLATE KINASE (DTMP KINASE); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | THYMIDINE KINASE; Identified by sequence similarity; possible; similar to SWISS-PROT:Q03221 (KITH_BACSU) Blastp2 P=2e-35 C=58%. | 0.941 |
MYPU_0520 | MYPU_2780 | gene:17576631 | gene:17576868 | THYMIDYLATE KINASE (DTMP KINASE); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | DEOXYCYTIDYLATE DEAMINASE (DCMP DEAMINASE); Identified by sequence similarity; probable; similar to SWISS-PROT:P32321 (DCTD_HUMAN) Blastp2 P=5e-38 C=66%. | 0.925 |
MYPU_0520 | MYPU_5380 | gene:17576631 | gene:17577140 | THYMIDYLATE KINASE (DTMP KINASE); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | THYMIDYLATE SYNTHASE (TS) (TSASE); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.942 |
MYPU_0520 | MYPU_5390 | gene:17576631 | gene:17577141 | THYMIDYLATE KINASE (DTMP KINASE); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE BETA CHAIN (RIBONUCLEOTIDE REDUCTASE); Identified by sequence similarity; probable; similar to SWISS-PROT:P75461 (RIR2_MYCPN) Blastp2 P=0 C=77%. | 0.931 |
MYPU_0520 | MYPU_5410 | gene:17576631 | gene:17577143 | THYMIDYLATE KINASE (DTMP KINASE); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA CHAIN (RIBONUCLEOTIDE REDUCTASE); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.941 |
MYPU_0550 | MYPU_0520 | gene:17576635 | gene:17576631 | 5'-NUCLEOTIDASE PRECURSOR; Identified by sequence similarity; putative; similar to SWISS-PROT:P22848 (5NTD_VIBPA) Blastp2 P=5e-36 C=42%; Belongs to the 5'-nucleotidase family. | THYMIDYLATE KINASE (DTMP KINASE); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.911 |
MYPU_0550 | MYPU_1450 | gene:17576635 | gene:17576729 | 5'-NUCLEOTIDASE PRECURSOR; Identified by sequence similarity; putative; similar to SWISS-PROT:P22848 (5NTD_VIBPA) Blastp2 P=5e-36 C=42%; Belongs to the 5'-nucleotidase family. | THYMIDINE KINASE; Identified by sequence similarity; possible; similar to SWISS-PROT:Q03221 (KITH_BACSU) Blastp2 P=2e-35 C=58%. | 0.905 |
MYPU_0550 | MYPU_2780 | gene:17576635 | gene:17576868 | 5'-NUCLEOTIDASE PRECURSOR; Identified by sequence similarity; putative; similar to SWISS-PROT:P22848 (5NTD_VIBPA) Blastp2 P=5e-36 C=42%; Belongs to the 5'-nucleotidase family. | DEOXYCYTIDYLATE DEAMINASE (DCMP DEAMINASE); Identified by sequence similarity; probable; similar to SWISS-PROT:P32321 (DCTD_HUMAN) Blastp2 P=5e-38 C=66%. | 0.905 |
MYPU_0550 | MYPU_5380 | gene:17576635 | gene:17577140 | 5'-NUCLEOTIDASE PRECURSOR; Identified by sequence similarity; putative; similar to SWISS-PROT:P22848 (5NTD_VIBPA) Blastp2 P=5e-36 C=42%; Belongs to the 5'-nucleotidase family. | THYMIDYLATE SYNTHASE (TS) (TSASE); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.908 |
MYPU_1450 | MYPU_0520 | gene:17576729 | gene:17576631 | THYMIDINE KINASE; Identified by sequence similarity; possible; similar to SWISS-PROT:Q03221 (KITH_BACSU) Blastp2 P=2e-35 C=58%. | THYMIDYLATE KINASE (DTMP KINASE); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.941 |
MYPU_1450 | MYPU_0550 | gene:17576729 | gene:17576635 | THYMIDINE KINASE; Identified by sequence similarity; possible; similar to SWISS-PROT:Q03221 (KITH_BACSU) Blastp2 P=2e-35 C=58%. | 5'-NUCLEOTIDASE PRECURSOR; Identified by sequence similarity; putative; similar to SWISS-PROT:P22848 (5NTD_VIBPA) Blastp2 P=5e-36 C=42%; Belongs to the 5'-nucleotidase family. | 0.905 |
MYPU_1450 | MYPU_2780 | gene:17576729 | gene:17576868 | THYMIDINE KINASE; Identified by sequence similarity; possible; similar to SWISS-PROT:Q03221 (KITH_BACSU) Blastp2 P=2e-35 C=58%. | DEOXYCYTIDYLATE DEAMINASE (DCMP DEAMINASE); Identified by sequence similarity; probable; similar to SWISS-PROT:P32321 (DCTD_HUMAN) Blastp2 P=5e-38 C=66%. | 0.930 |
MYPU_1450 | MYPU_3390 | gene:17576729 | gene:17576930 | THYMIDINE KINASE; Identified by sequence similarity; possible; similar to SWISS-PROT:Q03221 (KITH_BACSU) Blastp2 P=2e-35 C=58%. | SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.436 |
MYPU_1450 | MYPU_5370 | gene:17576729 | gene:17577139 | THYMIDINE KINASE; Identified by sequence similarity; possible; similar to SWISS-PROT:Q03221 (KITH_BACSU) Blastp2 P=2e-35 C=58%. | DIHYDROFOLATE REDUCTASE; Identified by sequence similarity; probable; similar to SWISS-PROT:P47470 (DYR_MYCGE) Blastp2 P=6e-39 C=64%; Belongs to the dihydrofolate reductase family. | 0.435 |
MYPU_1450 | MYPU_5380 | gene:17576729 | gene:17577140 | THYMIDINE KINASE; Identified by sequence similarity; possible; similar to SWISS-PROT:Q03221 (KITH_BACSU) Blastp2 P=2e-35 C=58%. | THYMIDYLATE SYNTHASE (TS) (TSASE); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.961 |
MYPU_2580 | MYPU_3390 | gene:17576848 | gene:17576930 | FOLD BIFUNCTIONAL PROTEIN [INCLUDES: METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.5); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.978 |