node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PAB0654 | purP | PAB0654 | PAB0547 | Hypothetical protein, DUF54 family; Belongs to the UPF0201 family. | Putative carboligase of the ATP-grasp superfamily; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.775 |
PAB0654 | purP-2 | PAB0654 | PAB1272 | Hypothetical protein, DUF54 family; Belongs to the UPF0201 family. | Hypothetical protein. | 0.771 |
PAB1965 | guaB | PAB1965 | PAB1250 | Hypothetical protein. | guaB inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) (IMP dehydrogenase) (IMPDH) (IMPD); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.644 |
PAB1965 | purP | PAB1965 | PAB0547 | Hypothetical protein. | Putative carboligase of the ATP-grasp superfamily; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.761 |
guaA-C | guaA-N | PAB2417 | PAB0549 | guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | guaA-N GMP synthase-glutamine amidotransferase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | 0.999 |
guaA-C | guaB | PAB2417 | PAB1250 | guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | guaB inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) (IMP dehydrogenase) (IMPDH) (IMPD); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA-C | purA | PAB2417 | PAB1303 | guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | purA adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.836 |
guaA-C | purB | PAB2417 | PAB0829 | guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | purB adenylosuccinate lyase (EC 4.3.2.2). | 0.906 |
guaA-C | purP | PAB2417 | PAB0547 | guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | Putative carboligase of the ATP-grasp superfamily; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.842 |
guaA-C | purP-2 | PAB2417 | PAB1272 | guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | Hypothetical protein. | 0.400 |
guaA-C | purQ | PAB2417 | PAB1200 | guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | purQ phosphoribosylformylglycinamidine synthase I (EC 6.3.5.3); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is t [...] | 0.780 |
guaA-C | purS | PAB2417 | PAB3433 | guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | purS phosphoribosylformylglycinamidine (FGAM) synthase, purS component; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL [...] | 0.556 |
guaA-N | guaA-C | PAB0549 | PAB2417 | guaA-N GMP synthase-glutamine amidotransferase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | 0.999 |
guaA-N | guaB | PAB0549 | PAB1250 | guaA-N GMP synthase-glutamine amidotransferase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | guaB inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) (IMP dehydrogenase) (IMPDH) (IMPD); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.995 |
guaA-N | purA | PAB0549 | PAB1303 | guaA-N GMP synthase-glutamine amidotransferase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | purA adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.924 |
guaA-N | purB | PAB0549 | PAB0829 | guaA-N GMP synthase-glutamine amidotransferase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | purB adenylosuccinate lyase (EC 4.3.2.2). | 0.866 |
guaA-N | purP | PAB0549 | PAB0547 | guaA-N GMP synthase-glutamine amidotransferase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | Putative carboligase of the ATP-grasp superfamily; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. Belongs to the phosphohexose mutase family. | 0.820 |
guaA-N | purQ | PAB0549 | PAB1200 | guaA-N GMP synthase-glutamine amidotransferase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | purQ phosphoribosylformylglycinamidine synthase I (EC 6.3.5.3); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is t [...] | 0.736 |
guaA-N | purS | PAB0549 | PAB3433 | guaA-N GMP synthase-glutamine amidotransferase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | purS phosphoribosylformylglycinamidine (FGAM) synthase, purS component; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL [...] | 0.511 |
guaB | PAB1965 | PAB1250 | PAB1965 | guaB inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) (IMP dehydrogenase) (IMPDH) (IMPD); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Hypothetical protein. | 0.644 |