STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
taw3-1Hypothetical protein; S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72; Belongs to the TYW3 family. (194 aa)    
Predicted Functional Partners:
taw2
Hypothetical protein, Met-10+ like protein; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).
  
 0.927
taw1
Radical SAM family protein; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
  
  
 0.902
PAB0614
Putative amidohydrolase, acetamidase/formamidase family.
       0.693
PAB2181
Hypothetical protein.
  
     0.582
PAB0124
Predicted GTPase or GTP-binding protein; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA (By similarity).
  
     0.526
PAB2389
idsA-like multifunctional short chain isoprenyl diphosphate synthase; Belongs to the FPP/GGPP synthase family.
  
    0.506
rnj
Metallo-beta-lactamase superfamily protein; A highly processive 5'-3' exoribonuclease; no evidence has been seen for endonuclease activity. Prefers 5'-phosphate or 5'- hydroxyl ends; 5'-triphosphate substrates are very poorly degraded, does not degrade circular RNA. Does not degrade pre-tRNA(Trp) suggesting it is inhibited by strong secondary structures. Also degrades ssNDA but not dsDNA.
       0.496
PAB1753
Hypothetical protein.
       0.496
PAB1561
DNA helicase, putative.
 
     0.480
PAB2042
Hypothetical protein, containing PIN domain.
   
    0.480
Your Current Organism:
Pyrococcus abyssi
NCBI taxonomy Id: 272844
Other names: P. abyssi GE5, Pyrococcus abyssi GE5, Pyrococcus abyssi str. GE5, Pyrococcus abyssi str. Orsay, Pyrococcus abyssi strain GE5
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