node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PAB1235 | guaA-C | PAB1235 | PAB2417 | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | 0.970 |
PAB1235 | guaA-N | PAB1235 | PAB0549 | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | guaA-N GMP synthase-glutamine amidotransferase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | 0.935 |
PAB1235 | guaB | PAB1235 | PAB1250 | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | guaB inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) (IMP dehydrogenase) (IMPDH) (IMPD); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.948 |
PAB1235 | purA | PAB1235 | PAB1303 | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | purA adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.615 |
guaA-C | PAB1235 | PAB2417 | PAB1235 | guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.970 |
guaA-C | guaA-N | PAB2417 | PAB0549 | guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | guaA-N GMP synthase-glutamine amidotransferase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | 0.999 |
guaA-C | guaB | PAB2417 | PAB1250 | guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | guaB inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) (IMP dehydrogenase) (IMPDH) (IMPD); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA-C | purA | PAB2417 | PAB1303 | guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | purA adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.836 |
guaA-C | purB | PAB2417 | PAB0829 | guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | purB adenylosuccinate lyase (EC 4.3.2.2). | 0.906 |
guaA-C | purF | PAB2417 | PAB0151 | guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | purF amidophosphoribosyltransferase (EC 2.4.2.14); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.771 |
guaA-C | purL | PAB2417 | PAB1201 | guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | purL phosphoribosylformylglycinamidine synthase II (EC 6.3.5.3); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is [...] | 0.858 |
guaA-C | purM | PAB2417 | PAB1083 | guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | purM phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1). | 0.735 |
guaA-C | purQ | PAB2417 | PAB1200 | guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | purQ phosphoribosylformylglycinamidine synthase I (EC 6.3.5.3); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is t [...] | 0.780 |
guaA-C | rpoB | PAB2417 | PAB0423 | guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | rpoB DNA-directed RNA polymerase, subunit B (EC 2.7.7.6); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.870 |
guaA-N | PAB1235 | PAB0549 | PAB1235 | guaA-N GMP synthase-glutamine amidotransferase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.935 |
guaA-N | guaA-C | PAB0549 | PAB2417 | guaA-N GMP synthase-glutamine amidotransferase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | 0.999 |
guaA-N | guaB | PAB0549 | PAB1250 | guaA-N GMP synthase-glutamine amidotransferase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | guaB inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) (IMP dehydrogenase) (IMPDH) (IMPD); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.995 |
guaA-N | purA | PAB0549 | PAB1303 | guaA-N GMP synthase-glutamine amidotransferase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | purA adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.924 |
guaA-N | purB | PAB0549 | PAB0829 | guaA-N GMP synthase-glutamine amidotransferase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | purB adenylosuccinate lyase (EC 4.3.2.2). | 0.866 |
guaA-N | purF | PAB0549 | PAB0151 | guaA-N GMP synthase-glutamine amidotransferase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP. | purF amidophosphoribosyltransferase (EC 2.4.2.14); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.774 |