node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PAB0591 | PAB2385 | PAB0591 | PAB2385 | Putative DEAH ATP-dependent helicase. | ERCC2/XPD/rad3 DNA repair helicase, TFIIH helicase beta subunit homolog. | 0.759 |
PAB0591 | fen | PAB0591 | PAB1877 | Putative DEAH ATP-dependent helicase. | Fen1 FLAP endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathw [...] | 0.975 |
PAB0591 | lig | PAB0591 | PAB2002 | Putative DEAH ATP-dependent helicase. | Lig DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.531 |
PAB0591 | pcn | PAB0591 | PAB1465 | Putative DEAH ATP-dependent helicase. | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (By similarity). Regulates activity of NucS endonuclease and prevents non- specific cleavage. | 0.897 |
PAB0591 | polI | PAB0591 | PAB1128 | Putative DEAH ATP-dependent helicase. | polI DNA polymerase I. | 0.823 |
PAB0591 | rad32 | PAB0591 | PAB0811 | Putative DEAH ATP-dependent helicase. | Rad32/mre11 DNA repair protein (EC 3.1.-.-); Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.754 |
PAB2385 | PAB0591 | PAB2385 | PAB0591 | ERCC2/XPD/rad3 DNA repair helicase, TFIIH helicase beta subunit homolog. | Putative DEAH ATP-dependent helicase. | 0.759 |
PAB2385 | fen | PAB2385 | PAB1877 | ERCC2/XPD/rad3 DNA repair helicase, TFIIH helicase beta subunit homolog. | Fen1 FLAP endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathw [...] | 0.922 |
PAB2385 | lig | PAB2385 | PAB2002 | ERCC2/XPD/rad3 DNA repair helicase, TFIIH helicase beta subunit homolog. | Lig DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.774 |
PAB2385 | pcn | PAB2385 | PAB1465 | ERCC2/XPD/rad3 DNA repair helicase, TFIIH helicase beta subunit homolog. | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (By similarity). Regulates activity of NucS endonuclease and prevents non- specific cleavage. | 0.805 |
PAB2385 | polB | PAB2385 | PAB2266 | ERCC2/XPD/rad3 DNA repair helicase, TFIIH helicase beta subunit homolog. | dp1/polB intein containing DNA polymerase II small subunit (2.7.7.7); Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity); Belongs to the DNA polymerase delta/II small subunit family. | 0.731 |
PAB2385 | polI | PAB2385 | PAB1128 | ERCC2/XPD/rad3 DNA repair helicase, TFIIH helicase beta subunit homolog. | polI DNA polymerase I. | 0.772 |
PAB2385 | rad32 | PAB2385 | PAB0811 | ERCC2/XPD/rad3 DNA repair helicase, TFIIH helicase beta subunit homolog. | Rad32/mre11 DNA repair protein (EC 3.1.-.-); Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.866 |
PAB2385 | rfcS | PAB2385 | PAB0068 | ERCC2/XPD/rad3 DNA repair helicase, TFIIH helicase beta subunit homolog. | rfcS intein containing activator 1, replication factor C, small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-independent ATPase activity; Belongs to the activator 1 small subunits family. RfcS subfamily. | 0.702 |
fen | PAB0591 | PAB1877 | PAB0591 | Fen1 FLAP endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathw [...] | Putative DEAH ATP-dependent helicase. | 0.975 |
fen | PAB2385 | PAB1877 | PAB2385 | Fen1 FLAP endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathw [...] | ERCC2/XPD/rad3 DNA repair helicase, TFIIH helicase beta subunit homolog. | 0.922 |
fen | lig | PAB1877 | PAB2002 | Fen1 FLAP endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathw [...] | Lig DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.972 |
fen | pcn | PAB1877 | PAB1465 | Fen1 FLAP endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathw [...] | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (By similarity). Regulates activity of NucS endonuclease and prevents non- specific cleavage. | 0.999 |
fen | polB | PAB1877 | PAB2266 | Fen1 FLAP endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathw [...] | dp1/polB intein containing DNA polymerase II small subunit (2.7.7.7); Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity); Belongs to the DNA polymerase delta/II small subunit family. | 0.982 |
fen | polI | PAB1877 | PAB1128 | Fen1 FLAP endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathw [...] | polI DNA polymerase I. | 0.979 |