node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PAB0691 | ilvB | PAB0691 | PAB0888 | Acetolactate synthase, small chain. | ilvB acetolactate synthase, large subunit. | 0.998 |
PAB0691 | ilvC | PAB0691 | PAB0889 | Acetolactate synthase, small chain. | ilvC ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.987 |
PAB0691 | ilvD | PAB0691 | PAB0895 | Acetolactate synthase, small chain. | ilvD dihydroxy-acid dehydratase (EC 4.2.1.9); Belongs to the IlvD/Edd family. | 0.870 |
PAB0691 | leuA-1 | PAB0691 | PAB0890 | Acetolactate synthase, small chain. | leuA-1 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). | 0.636 |
PAB0691 | leuA-3 | PAB0691 | PAB0894 | Acetolactate synthase, small chain. | leuA homolog alpha-isopropylmalate synthase related; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.636 |
PAB0691 | leuB-1 | PAB0691 | PAB2424 | Acetolactate synthase, small chain. | leuB-1 3-isopropylmalate dehydrogenase. | 0.830 |
PAB0691 | leuC-1 | PAB0691 | PAB0891 | Acetolactate synthase, small chain. | leuC-1 3-isopropylmalate dehydratase large subunit (isopropylmalate isomerase) (EC 4.2.1.33); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.831 |
PAB0691 | leuC-2 | PAB0691 | PAB0287 | Acetolactate synthase, small chain. | leuC-2 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.831 |
PAB0691 | leuD-1 | PAB0691 | PAB0892 | Acetolactate synthase, small chain. | leuD-1 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.814 |
PAB0691 | leuD-2 | PAB0691 | PAB0288 | Acetolactate synthase, small chain. | leuD-2 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.814 |
ilvB | PAB0691 | PAB0888 | PAB0691 | ilvB acetolactate synthase, large subunit. | Acetolactate synthase, small chain. | 0.998 |
ilvB | ilvC | PAB0888 | PAB0889 | ilvB acetolactate synthase, large subunit. | ilvC ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
ilvB | ilvD | PAB0888 | PAB0895 | ilvB acetolactate synthase, large subunit. | ilvD dihydroxy-acid dehydratase (EC 4.2.1.9); Belongs to the IlvD/Edd family. | 0.998 |
ilvB | leuA-1 | PAB0888 | PAB0890 | ilvB acetolactate synthase, large subunit. | leuA-1 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). | 0.989 |
ilvB | leuA-3 | PAB0888 | PAB0894 | ilvB acetolactate synthase, large subunit. | leuA homolog alpha-isopropylmalate synthase related; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.955 |
ilvB | leuB-1 | PAB0888 | PAB2424 | ilvB acetolactate synthase, large subunit. | leuB-1 3-isopropylmalate dehydrogenase. | 0.982 |
ilvB | leuC-1 | PAB0888 | PAB0891 | ilvB acetolactate synthase, large subunit. | leuC-1 3-isopropylmalate dehydratase large subunit (isopropylmalate isomerase) (EC 4.2.1.33); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.837 |
ilvB | leuC-2 | PAB0888 | PAB0287 | ilvB acetolactate synthase, large subunit. | leuC-2 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.597 |
ilvB | leuD-1 | PAB0888 | PAB0892 | ilvB acetolactate synthase, large subunit. | leuD-1 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.834 |
ilvB | leuD-2 | PAB0888 | PAB0288 | ilvB acetolactate synthase, large subunit. | leuD-2 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.750 |